GLSI vs. SOXL

Last updated Jun 24, 2026

GLSI (Greenwich LifeSciences, Inc.) is a stock, while SOXL (Direxion Daily Semiconductor Bull 3X ETF) is Leveraged Equities fund tracking the ICE Semiconductor Index. Over the past 5 years, GLSI returned -12.03%/yr vs 42.16%/yr for SOXL. At a 0.28 correlation, their price movements are largely independent.

Performance

GLSI vs. SOXL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Greenwich LifeSciences, Inc. (GLSI) and Direxion Daily Semiconductor Bull 3X ETF (SOXL). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, GLSI achieves a 9.61% return, which is significantly lower than SOXL's 450.61% return.

GLSI

• 1D: -3.03%
• 1M: -16.71%
• YTD: 9.61%
• 6M: 58.06%
• 1Y: 162.90%
• 3Y*: 33.64%
• 5Y*: -12.03%
• 10Y*: —

SOXL

• 1D: -23.06%
• 1M: 21.44%
• YTD: 450.61%
• 6M: 429.57%
• 1Y: 976.09%
• 3Y*: 120.84%
• 5Y*: 42.16%
• 10Y*: 64.56%

*Multi-year figures are annualized to reflect compound growth (CAGR)

GLSI vs. SOXL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
GLSI Greenwich LifeSciences, Inc.	9.61%	87.09%	6.75%	-30.79%	-37.53%	-33.29%	534.26%
SOXL Direxion Daily Semiconductor Bull 3X ETF	450.61%	54.91%	-12.31%	226.98%	-85.66%	118.84%	109.92%

Correlation

The correlation between GLSI and SOXL is 0.22, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.22
Correlation (3Y) Calculated over the trailing 3-year period	0.28
Correlation (5Y) Calculated over the trailing 5-year period	0.30
Correlation (All Time) Calculated using the full available price history since Sep 25, 2020	0.28

Return for Risk

GLSI vs. SOXL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GLSI

GLSI Risk / Return Rank: 85
GLSI Sharpe Ratio Rank: 86
GLSI Sortino Ratio Rank: 84
GLSI Omega Ratio Rank: 81
GLSI Calmar Ratio Rank: 90
GLSI Martin Ratio Rank: 84

SOXL

SOXL Risk / Return Rank: 96
SOXL Sharpe Ratio Rank: 99
SOXL Sortino Ratio Rank: 90
SOXL Omega Ratio Rank: 92
SOXL Calmar Ratio Rank: 99
SOXL Martin Ratio Rank: 98

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GLSI vs. SOXL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Greenwich LifeSciences, Inc. (GLSI) and Direxion Daily Semiconductor Bull 3X ETF (SOXL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GLSI	SOXL	Difference
Sharpe ratio: Return per unit of total volatility	1.76	8.45	-6.68
Sortino ratio: Return per unit of downside risk	2.48	4.03	-1.55
Omega ratio: Gain probability vs. loss probability	1.30	1.58	-0.28
Calmar ratio: Return relative to maximum drawdown	4.41	22.69	-18.28
Martin ratio: Return relative to average drawdown	7.80	72.83	-65.03

GLSI vs. SOXL - Sharpe Ratio Comparison

The current GLSI Sharpe Ratio is 1.76, which is lower than the SOXL Sharpe Ratio of 8.45. The chart below compares the historical Sharpe Ratios of GLSI and SOXL, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GLSI vs. SOXL - Drawdown Comparison

The maximum GLSI drawdown since its inception was -90.11%, roughly equal to the maximum SOXL drawdown of -90.46%. Use the drawdown chart below to compare losses from any high point for GLSI and SOXL.

Drawdown Indicators

	GLSI	SOXL	Difference
Max Drawdown Largest peak-to-trough decline	-90.11%	-90.46%	+0.35%
Max Drawdown (1Y) Largest decline over 1 year	-37.15%	-43.47%	+6.32%
Max Drawdown (3Y) Largest decline over 3 years	-61.37%	-87.88%	+26.51%
Max Drawdown (5Y) Largest decline over 5 years	-84.90%	-90.46%	+5.56%
Max Drawdown (10Y) Largest decline over 10 years	—	-90.46%	—
Current Drawdown Current decline from peak	-68.11%	-23.06%	-45.05%
Average Drawdown Average peak-to-trough decline	-72.75%	-34.95%	-37.80%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.97%	13.52%	+7.45%

Volatility

GLSI vs. SOXL - Volatility Comparison

The current volatility for Greenwich LifeSciences, Inc. (GLSI) is 24.96%, while Direxion Daily Semiconductor Bull 3X ETF (SOXL) has a volatility of 68.39%. This indicates that GLSI experiences smaller price fluctuations and is considered to be less risky than SOXL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GLSI	SOXL	Difference
Volatility (1M) Calculated over the trailing 1-month period	24.96%	68.39%	-43.43%
Volatility (6M) Calculated over the trailing 6-month period	80.55%	99.84%	-19.29%
Volatility (1Y) Calculated over the trailing 1-year period	92.95%	116.79%	-23.84%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	78.67%	110.35%	-31.68%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	426.56%	100.62%	+325.94%

Dividends

GLSI vs. SOXL - Dividend Comparison

GLSI has not paid dividends to shareholders, while SOXL's dividend yield for the trailing twelve months is around 0.03%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016
GLSI Greenwich LifeSciences, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SOXL Direxion Daily Semiconductor Bull 3X ETF	0.03%	0.34%	1.18%	0.51%	1.07%	0.04%	0.05%	0.38%	1.30%	0.09%	4.84%

Frequently Asked Questions

Can I hold both GLSI and SOXL in my portfolio?

GLSI and SOXL have a correlation of 0.22, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, GLSI or SOXL?

SOXL has higher volatility (68.39%) compared to GLSI (24.96%). In terms of maximum drawdown, GLSI dropped -90.11% vs SOXL's -90.46%.

Which has better risk-adjusted returns?

SOXL currently has the higher Sharpe Ratio (8.45 vs 1.76), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.