FBIOX vs. LYFIX

Last updated Jun 4, 2026

FBIOX (Fidelity Select Biotechnology Portfolio) and LYFIX (AlphaCentric LifeSci Healthcare Fund) are both Health & Biotech Equities funds. Over the past 5 years, FBIOX returned 5.77%/yr vs 5.20%/yr for LYFIX. Their correlation of 0.86 suggests significant overlap in exposure. FBIOX charges 0.69%/yr vs 1.40%/yr for LYFIX.

Performance

FBIOX vs. LYFIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Fidelity Select Biotechnology Portfolio (FBIOX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, FBIOX achieves a 0.03% return, which is significantly higher than LYFIX's -0.57% return.

FBIOX

• 1D: -3.67%
• 1M: -3.79%
• YTD: 0.03%
• 6M: -0.21%
• 1Y: 42.15%
• 3Y*: 15.71%
• 5Y*: 5.77%
• 10Y*: 9.09%

LYFIX

• 1D: -3.07%
• 1M: -1.86%
• YTD: -0.57%
• 6M: -1.29%
• 1Y: 33.09%
• 3Y*: 6.91%
• 5Y*: 5.20%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

FBIOX vs. LYFIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
FBIOX Fidelity Select Biotechnology Portfolio	0.03%	36.38%	7.26%	10.09%	-15.87%	-12.26%	38.62%	3.64%
LYFIX AlphaCentric LifeSci Healthcare Fund	-0.57%	28.22%	-0.27%	7.19%	-0.92%	-3.42%	54.83%	1.20%

Correlation

The correlation between FBIOX and LYFIX is 0.90, indicating a strong positive relationship between their price movements. Combining them offers limited diversification - they tend to fall together during downturns.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.90
Correlation (3Y) Calculated over the trailing 3-year period	0.85
Correlation (5Y) Calculated over the trailing 5-year period	0.86
Correlation (All Time) Calculated using the full available price history since Dec 2, 2019	0.86

The correlation between FBIOX and LYFIX has been stable across timeframes, ranging from 0.85 to 0.90 - a consistent structural relationship.

Return for Risk

FBIOX vs. LYFIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

FBIOX

FBIOX Risk / Return Rank: 66
FBIOX Sharpe Ratio Rank: 53
FBIOX Sortino Ratio Rank: 50
FBIOX Omega Ratio Rank: 43
FBIOX Calmar Ratio Rank: 95
FBIOX Martin Ratio Rank: 90

LYFIX

LYFIX Risk / Return Rank: 55
LYFIX Sharpe Ratio Rank: 41
LYFIX Sortino Ratio Rank: 39
LYFIX Omega Ratio Rank: 35
LYFIX Calmar Ratio Rank: 84
LYFIX Martin Ratio Rank: 77

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

FBIOX vs. LYFIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Fidelity Select Biotechnology Portfolio (FBIOX) and AlphaCentric LifeSci Healthcare Fund (LYFIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	FBIOX	LYFIX	Difference
Sharpe ratio: Return per unit of total volatility	2.15	1.86	+0.29
Sortino ratio: Return per unit of downside risk	2.96	2.63	+0.33
Omega ratio: Gain probability vs. loss probability	1.35	1.31	+0.04
Calmar ratio: Return relative to maximum drawdown	5.81	3.95	+1.85
Martin ratio: Return relative to average drawdown	18.24	14.43	+3.81
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

FBIOX vs. LYFIX - Sharpe Ratio Comparison

The current FBIOX Sharpe Ratio is 2.15, which is comparable to the LYFIX Sharpe Ratio of 1.86. The chart below compares the historical Sharpe Ratios of FBIOX and LYFIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	FBIOX	LYFIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.15	1.86	+0.29
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.23	0.23	0.00
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.35	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.47	0.50	-0.03

Drawdowns

FBIOX vs. LYFIX - Drawdown Comparison

The maximum FBIOX drawdown since its inception was -71.98%, which is greater than LYFIX's maximum drawdown of -35.33%. Use the drawdown chart below to compare losses from any high point for FBIOX and LYFIX.

Drawdown Indicators

	FBIOX	LYFIX	Difference
Max Drawdown Largest peak-to-trough decline	-71.98%	-35.33%	-36.65%
Max Drawdown (1Y) Largest decline over 1 year	-7.62%	-8.49%	+0.87%
Max Drawdown (3Y) Largest decline over 3 years	-27.83%	-24.22%	-3.61%
Max Drawdown (5Y) Largest decline over 5 years	-44.87%	-32.45%	-12.42%
Max Drawdown (10Y) Largest decline over 10 years	-48.66%	—	—
Current Drawdown Current decline from peak	-7.02%	-4.93%	-2.09%
Average Drawdown Average peak-to-trough decline	-23.63%	-9.87%	-13.76%
Ulcer Index Depth and duration of drawdowns from previous peaks	2.42%	2.32%	+0.10%

Volatility

FBIOX vs. LYFIX - Volatility Comparison

Fidelity Select Biotechnology Portfolio (FBIOX) has a higher volatility of 7.50% compared to AlphaCentric LifeSci Healthcare Fund (LYFIX) at 6.64%. This indicates that FBIOX's price experiences larger fluctuations and is considered to be riskier than LYFIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	FBIOX	LYFIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	7.50%	6.64%	+0.86%
Volatility (6M) Calculated over the trailing 6-month period	16.31%	14.56%	+1.75%
Volatility (1Y) Calculated over the trailing 1-year period	20.71%	18.05%	+2.66%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.96%	22.87%	+2.09%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	26.25%	23.41%	+2.84%

FBIOX vs. LYFIX - Expense Ratio Comparison

FBIOX has a 0.69% expense ratio, which is lower than LYFIX's 1.40% expense ratio.

Dividends

FBIOX vs. LYFIX - Dividend Comparison

FBIOX's dividend yield for the trailing twelve months is around 6.72%, more than LYFIX's 1.79% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
FBIOX Fidelity Select Biotechnology Portfolio	6.72%	2.47%	1.21%	0.45%	0.00%	14.48%	19.46%	8.89%	11.18%	1.41%	3.42%	6.71%
LYFIX AlphaCentric LifeSci Healthcare Fund	1.79%	1.78%	2.24%	2.63%	4.43%	12.88%	2.30%	0.00%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both FBIOX and LYFIX in my portfolio?

With a correlation of 0.90, FBIOX and LYFIX move almost identically. Holding both adds very little diversification - you're essentially doubling your position in the same market segment. Choosing one is usually more capital-efficient.

Which is riskier, FBIOX or LYFIX?

FBIOX has higher volatility (7.50%) compared to LYFIX (6.64%). In terms of maximum drawdown, FBIOX dropped -71.98% vs LYFIX's -35.33%.

Which has better risk-adjusted returns?

FBIOX currently has the higher Sharpe Ratio (2.15 vs 1.86), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.