EPAI vs. MEDI

Last updated Jun 4, 2026

EPAI (Harbor AI Inflection Strategy ETF) and MEDI (Harbor Health Care ETF) are both exchange-traded funds - EPAI is a Technology Equities fund actively managed by Harbor, while MEDI is a Health & Biotech Equities fund actively managed by Harbor. Both are actively managed. At a 0.27 correlation, their price movements are largely independent. EPAI charges 0.88%/yr vs 0.80%/yr for MEDI.

Performance

EPAI vs. MEDI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Harbor AI Inflection Strategy ETF (EPAI) and Harbor Health Care ETF (MEDI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, EPAI achieves a 47.68% return, which is significantly higher than MEDI's -4.02% return.

EPAI

• 1D: 0.85%
• 1M: 9.43%
• YTD: 47.68%
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

MEDI

• 1D: 1.06%
• 1M: -0.93%
• YTD: -4.02%
• 6M: -4.83%
• 1Y: 18.27%
• 3Y*: 12.46%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

EPAI vs. MEDI - Yearly Performance Comparison

	2026 (YTD)	2025
EPAI Harbor AI Inflection Strategy ETF	47.68%	0.86%
MEDI Harbor Health Care ETF	-4.02%	1.96%

Correlation

The correlation between EPAI and MEDI is 0.27, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (All Time) Calculated using the full available price history since Dec 19, 2025	0.27

Return for Risk

EPAI vs. MEDI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

MEDI

MEDI Risk / Return Rank: 26
MEDI Sharpe Ratio Rank: 26
MEDI Sortino Ratio Rank: 27
MEDI Omega Ratio Rank: 24
MEDI Calmar Ratio Rank: 25
MEDI Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

EPAI vs. MEDI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Harbor AI Inflection Strategy ETF (EPAI) and Harbor Health Care ETF (MEDI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	EPAI	MEDI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	0.93	—
Sharpe Ratio (All Time) Calculated using the full available price history	4.70	0.74	+3.96

Drawdowns

EPAI vs. MEDI - Drawdown Comparison

The maximum EPAI drawdown since its inception was -12.31%, smaller than the maximum MEDI drawdown of -19.24%. Use the drawdown chart below to compare losses from any high point for EPAI and MEDI.

Drawdown Indicators

	EPAI	MEDI	Difference
Max Drawdown Largest peak-to-trough decline	-12.31%	-19.24%	+6.93%
Max Drawdown (1Y) Largest decline over 1 year	—	-15.34%	—
Max Drawdown (3Y) Largest decline over 3 years	—	-19.24%	—
Current Drawdown Current decline from peak	0.00%	-8.01%	+8.01%
Average Drawdown Average peak-to-trough decline	-2.67%	-4.28%	+1.61%
Ulcer Index Depth and duration of drawdowns from previous peaks	—	5.10%	—

Volatility

Volatility by Period

	EPAI	MEDI	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	6.02%	—
Volatility (6M) Calculated over the trailing 6-month period	—	15.42%	—
Volatility (1Y) Calculated over the trailing 1-year period	30.61%	19.82%	+10.79%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	30.61%	18.63%	+11.98%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	30.61%	18.63%	+11.98%

EPAI vs. MEDI - Expense Ratio Comparison

EPAI has a 0.88% expense ratio, which is higher than MEDI's 0.80% expense ratio.

Dividends

EPAI vs. MEDI - Dividend Comparison

EPAI has not paid dividends to shareholders, while MEDI's dividend yield for the trailing twelve months is around 0.29%.

Position	TTM	2025	2024	2023
EPAI Harbor AI Inflection Strategy ETF	0.00%	0.00%	0.00%	0.00%
MEDI Harbor Health Care ETF	0.29%	0.28%	0.54%	1.86%

Frequently Asked Questions

Can I hold both EPAI and MEDI in my portfolio?

EPAI and MEDI have a correlation of 0.27, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, EPAI or MEDI?

On fees, MEDI is cheaper at 0.80% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, EPAI or MEDI?

MEDI is cheaper with a 0.80% expense ratio, compared with 0.88% for EPAI.

Which ETF pays a higher dividend yield, EPAI or MEDI?

MEDI has the higher dividend yield at 0.29%, compared with 0.00% for EPAI.

What is the main difference between EPAI and MEDI?

EPAI is categorized as Technology Equities, while MEDI is Health & Biotech Equities. Their fees differ too: 0.88% for EPAI and 0.80% for MEDI.