CYCN vs. VXRT

Last updated Jun 5, 2026

CYCN (Cyclerion Therapeutics, Inc.) and VXRT (Vaxart, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, CYCN returned -45.53%/yr vs -38.25%/yr for VXRT. At a 0.08 correlation, their price movements are largely independent.

Performance

CYCN vs. VXRT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CYCN achieves a 140.94% return, which is significantly higher than VXRT's 78.05% return.

CYCN

• 1D: 2.00%
• 1M: -2.86%
• YTD: 140.94%
• 6M: 80.00%
• 1Y: -2.24%
• 3Y*: -10.93%
• 5Y*: -45.53%
• 10Y*: —

VXRT

• 1D: 2.78%
• 1M: -18.31%
• YTD: 78.05%
• 6M: 66.70%
• 1Y: 52.67%
• 3Y*: -21.40%
• 5Y*: -38.25%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CYCN vs. VXRT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
CYCN Cyclerion Therapeutics, Inc.	140.94%	-60.56%	-3.88%	-74.47%	-61.85%	-43.79%	12.50%	-81.23%
VXRT Vaxart, Inc.	78.05%	-47.68%	15.59%	-40.39%	-84.67%	9.81%	1,529.10%	-82.39%

Correlation

The correlation between CYCN and VXRT is 0.10, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.10
Correlation (3Y) Calculated over the trailing 3-year period	0.03
Correlation (5Y) Calculated over the trailing 5-year period	0.10
Correlation (All Time) Calculated using the full available price history since Apr 3, 2019	0.08

Fundamentals

Market Cap CYCN : $12.87M VXRT : $149.37M
EPS CYCN : -$0.61 VXRT : $0.16
PS Ratio CYCN : 5.27 VXRT : 0.56
PB Ratio CYCN : 1.89 VXRT : 1.59
Total Revenue (TTM) CYCN : $1.99M VXRT : $255.61M
Gross Profit (TTM) CYCN : $1.99M VXRT : $193.63M
EBITDA (TTM) CYCN : -$6.70M VXRT : $45.63M

Return for Risk

CYCN vs. VXRT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CYCN

CYCN Risk / Return Rank: 59
CYCN Sharpe Ratio Rank: 41
CYCN Sortino Ratio Rank: 89
CYCN Omega Ratio Rank: 87
CYCN Calmar Ratio Rank: 40
CYCN Martin Ratio Rank: 40

VXRT

VXRT Risk / Return Rank: 62
VXRT Sharpe Ratio Rank: 58
VXRT Sortino Ratio Rank: 68
VXRT Omega Ratio Rank: 69
VXRT Calmar Ratio Rank: 61
VXRT Martin Ratio Rank: 56

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CYCN vs. VXRT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CYCN	VXRT	Difference
Sharpe ratio: Return per unit of total volatility	-0.01	0.50	-0.50
Sortino ratio: Return per unit of downside risk	3.09	1.60	+1.49
Omega ratio: Gain probability vs. loss probability	1.39	1.22	+0.18
Calmar ratio: Return relative to maximum drawdown	-0.03	0.92	-0.96
Martin ratio: Return relative to average drawdown	-0.05	1.45	-1.50
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CYCN vs. VXRT - Sharpe Ratio Comparison

The current CYCN Sharpe Ratio is -0.01, which is lower than the VXRT Sharpe Ratio of 0.50. The chart below compares the historical Sharpe Ratios of CYCN and VXRT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CYCN	VXRT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.01	0.50	-0.50
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.20	-0.41	+0.21
Sharpe Ratio (All Time) Calculated using the full available price history	-0.23	-0.21	-0.02

Drawdowns

CYCN vs. VXRT - Drawdown Comparison

The maximum CYCN drawdown since its inception was -99.71%, roughly equal to the maximum VXRT drawdown of -98.71%. Use the drawdown chart below to compare losses from any high point for CYCN and VXRT.

Drawdown Indicators

	CYCN	VXRT	Difference
Max Drawdown Largest peak-to-trough decline	-99.71%	-98.71%	-1.00%
Max Drawdown (1Y) Largest decline over 1 year	-70.33%	-57.26%	-13.07%
Max Drawdown (3Y) Largest decline over 3 years	-82.99%	-78.72%	-4.27%
Max Drawdown (5Y) Largest decline over 5 years	-98.74%	-96.94%	-1.80%
Current Drawdown Current decline from peak	-99.17%	-97.36%	-1.81%
Average Drawdown Average peak-to-trough decline	-87.74%	-82.94%	-4.80%
Ulcer Index Depth and duration of drawdowns from previous peaks	47.22%	36.31%	+10.91%

Volatility

CYCN vs. VXRT - Volatility Comparison

The current volatility for Cyclerion Therapeutics, Inc. (CYCN) is 8.83%, while Vaxart, Inc. (VXRT) has a volatility of 20.57%. This indicates that CYCN experiences smaller price fluctuations and is considered to be less risky than VXRT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CYCN	VXRT	Difference
Volatility (1M) Calculated over the trailing 1-month period	8.83%	20.57%	-11.74%
Volatility (6M) Calculated over the trailing 6-month period	161.83%	76.62%	+85.21%
Volatility (1Y) Calculated over the trailing 1-year period	328.07%	106.88%	+221.19%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	230.17%	93.04%	+137.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	204.14%	128.84%	+75.30%

Dividends

CYCN vs. VXRT - Dividend Comparison

Neither CYCN nor VXRT has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CYCN and VXRT in my portfolio?

CYCN and VXRT have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CYCN or VXRT?

VXRT has higher volatility (20.57%) compared to CYCN (8.83%). In terms of maximum drawdown, CYCN dropped -99.71% vs VXRT's -98.71%.

Which has better risk-adjusted returns?

VXRT currently has the higher Sharpe Ratio (0.50 vs -0.01), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.