CYCN vs. VXRT

Last updated Apr 1, 2026

Compare and contrast key facts about Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT).

Performance

CYCN vs. VXRT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). The values are adjusted to include any dividend payments, if applicable.

CYCN vs. VXRT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
CYCN Cyclerion Therapeutics, Inc.	22.05%	-60.56%	-3.88%	-74.47%	-61.85%	-43.79%	12.50%	-81.23%
VXRT Vaxart, Inc.	74.65%	-47.68%	15.59%	-40.39%	-84.67%	9.81%	1,529.10%	-82.39%

Fundamentals

Market Cap CYCN : $5.00M VXRT : $139.36M
EPS CYCN : -$0.70 VXRT : $0.07
PS Ratio CYCN : 1.71 VXRT : 0.58
PB Ratio CYCN : 0.52 VXRT : 1.59
Total Revenue (TTM) CYCN : $2.86M VXRT : $237.26M
Gross Profit (TTM) CYCN : $1.98M VXRT : $0.00
EBITDA (TTM) CYCN : -$3.60M VXRT : $18.07M

Returns By Period

In the year-to-date period, CYCN achieves a 22.05% return, which is significantly lower than VXRT's 74.65% return.

CYCN

• 1D: 7.27%
• 1M: 14.81%
• YTD: 22.05%
• 6M: -32.61%
• 1Y: -38.00%
• 3Y*: -43.68%
• 5Y*: -52.75%
• 10Y*: —

VXRT

• 1D: 0.83%
• 1M: -23.90%
• YTD: 74.65%
• 6M: 65.82%
• 1Y: 48.65%
• 3Y*: -7.19%
• 5Y*: -37.01%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

CYCN vs. VXRT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CYCN

CYCN Risk / Return Rank: 26
CYCN Sharpe Ratio Rank: 24
CYCN Sortino Ratio Rank: 29
CYCN Omega Ratio Rank: 29
CYCN Calmar Ratio Rank: 22
CYCN Martin Ratio Rank: 25

VXRT

VXRT Risk / Return Rank: 62
VXRT Sharpe Ratio Rank: 57
VXRT Sortino Ratio Rank: 69
VXRT Omega Ratio Rank: 68
VXRT Calmar Ratio Rank: 59
VXRT Martin Ratio Rank: 54

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CYCN vs. VXRT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CYCN	VXRT	Difference
Sharpe ratio Return per unit of total volatility	-0.39	0.43	-0.82
Sortino ratio Return per unit of downside risk	-0.03	1.55	-1.59
Omega ratio Gain probability vs. loss probability	1.00	1.20	-0.20
Calmar ratio Return relative to maximum drawdown	-0.56	0.76	-1.32
Martin ratio Return relative to average drawdown	-0.91	1.21	-2.12
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CYCN vs. VXRT - Sharpe Ratio Comparison

The current CYCN Sharpe Ratio is -0.39, which is lower than the VXRT Sharpe Ratio of 0.43. The chart below compares the historical Sharpe Ratios of CYCN and VXRT, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	CYCN	VXRT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.39	0.43	-0.82
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.29	-0.39	+0.10
Sharpe Ratio (All Time) Calculated using the full available price history	-0.31	-0.22	-0.10

Correlation

The correlation between CYCN and VXRT is 0.08, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

CYCN vs. VXRT - Dividend Comparison

Neither CYCN nor VXRT has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

CYCN vs. VXRT - Drawdown Comparison

The maximum CYCN drawdown since its inception was -99.71%, roughly equal to the maximum VXRT drawdown of -98.71%. Use the drawdown chart below to compare losses from any high point for CYCN and VXRT.

Drawdown Indicators

	CYCN	VXRT	Difference
Max Drawdown Largest peak-to-trough decline	-99.71%	-98.71%	-1.00%
Max Drawdown (1Y) Largest decline over 1 year	-70.81%	-57.26%	-13.55%
Max Drawdown (5Y) Largest decline over 5 years	-98.74%	-97.22%	-1.52%
Current Drawdown Current decline from peak	-99.58%	-97.41%	-2.17%
Average Drawdown Average peak-to-trough decline	-87.45%	-82.63%	-4.82%
Ulcer Index Depth and duration of drawdowns from previous peaks	43.47%	36.17%	+7.30%

Volatility

CYCN vs. VXRT - Volatility Comparison

The current volatility for Cyclerion Therapeutics, Inc. (CYCN) is 14.69%, while Vaxart, Inc. (VXRT) has a volatility of 27.15%. This indicates that CYCN experiences smaller price fluctuations and is considered to be less risky than VXRT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CYCN	VXRT	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.69%	27.15%	-12.46%
Volatility (6M) Calculated over the trailing 6-month period	64.44%	76.02%	-11.58%
Volatility (1Y) Calculated over the trailing 1-year period	98.10%	112.62%	-14.52%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	182.71%	96.15%	+86.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	168.88%	129.92%	+38.96%

Financials