CYCN vs. VXRT

Last updated Aug 1, 2026

CYCN (Cyclerion Therapeutics, Inc.) and VXRT (Vaxart, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, CYCN returned -43.20%/yr vs -40.42%/yr for VXRT. Their 0.08 correlation means their historical movements had little consistent relationship.

Performance

CYCN vs. VXRT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CYCN achieves a 170.87% return, which is significantly higher than VXRT's 55.89% return.

CYCN

• 1D: -1.71%
• 1M: 0.29%
• 6M: 152.94%
• YTD: 170.87%
• 1Y: 32.63%
• 3Y*: 1.39%
• 5Y*: -43.20%
• 10Y*: —
• ALL TIME*: -47.56%

VXRT

• 1D: 2.46%
• 1M: -15.63%
• 6M: -6.86%
• YTD: 55.89%
• 1Y: 51.77%
• 3Y*: -11.52%
• 5Y*: -40.42%
• 10Y*: —
• ALL TIME*: -27.88%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
CYCN Cyclerion Therapeutics, Inc.	$64.32K	$78.06K	$115.62K
VXRT Vaxart, Inc.	$154.47K	$165.76K	$219.97K

CYCN vs. VXRT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
CYCN Cyclerion Therapeutics, Inc.	170.87%	-60.56%	-3.88%	-74.47%	-61.85%	-43.79%	12.50%	-86.07%
VXRT Vaxart, Inc.	55.89%	-47.68%	15.59%	-40.39%	-84.67%	9.81%	1,529.10%	-82.82%

Correlation

The correlation between CYCN and VXRT is 0.06, meaning there was essentially no consistent relationship between their historical price movements. Each responded to its own set of market drivers.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.06
Correlation (3Y) Balances recent behavior with more history.	0.03
Correlation (5Y) Shows whether the relationship held over a longer period.	0.09
Correlation (All Time) Calculated using the full available price history since Apr 2, 2019	0.08

Fundamentals

Market Cap CYCN : $14.90M VXRT : $130.70M
EPS CYCN : -$0.59 VXRT : $0.16
PS Ratio CYCN : 6.13 VXRT : 0.49
PB Ratio CYCN : 2.13 VXRT : 1.39
Total Revenue (TTM) CYCN : $1.99M VXRT : $255.61M
Gross Profit (TTM) CYCN : $1.99M VXRT : $193.63M
EBITDA (TTM) CYCN : -$6.70M VXRT : $45.63M

Return for Risk

CYCN vs. VXRT — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

CYCN

CYCN Risk / Return Rank: 70
CYCN Sharpe Ratio Rank: 48
CYCN Sortino Ratio Rank: 96
CYCN Omega Ratio Rank: 95
CYCN Calmar Ratio Rank: 56
CYCN Martin Ratio Rank: 53

VXRT

VXRT Risk / Return Rank: 67
VXRT Sharpe Ratio Rank: 63
VXRT Sortino Ratio Rank: 69
VXRT Omega Ratio Rank: 70
VXRT Calmar Ratio Rank: 67
VXRT Martin Ratio Rank: 68

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

CYCN vs. VXRT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cyclerion Therapeutics, Inc. (CYCN) and Vaxart, Inc. (VXRT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CYCN	VXRT	Difference
Sharpe ratio: Return per unit of total volatility	0.09	0.53	-0.43
Sortino ratio: Return per unit of downside risk	3.58	1.46	+2.12
Omega ratio: Gain probability vs. loss probability	1.48	1.19	+0.29
Calmar ratio: Return relative to maximum drawdown	0.45	1.06	-0.61
Martin ratio: Return relative to average drawdown	0.64	2.52	-1.88

CYCN vs. VXRT - Sharpe Ratio Comparison

The current CYCN Sharpe Ratio is 0.09, which is lower than the VXRT Sharpe Ratio of 0.53. The chart below compares the historical Sharpe Ratios of CYCN and VXRT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CYCN vs. VXRT - Drawdown Comparison

The maximum CYCN drawdown since its inception was -99.72%, roughly equal to the maximum VXRT drawdown of -98.71%. Use the drawdown chart below to compare losses from any high point for CYCN and VXRT.

Drawdown Indicators

	CYCN	VXRT	Difference
Max Drawdown Largest peak-to-trough decline	-99.72%	-98.71%	-1.01%
Max Drawdown (1Y) Largest decline over 1 year	-66.77%	-43.74%	-23.03%
Max Drawdown (3Y) Largest decline over 3 years	-82.99%	-78.72%	-4.27%
Max Drawdown (5Y) Largest decline over 5 years	-98.45%	-96.94%	-1.51%
Current Drawdown Current decline from peak	-99.12%	-97.69%	-1.43%
Average Drawdown Average peak-to-trough decline	-88.61%	-83.17%	-5.44%
Ulcer Index Depth and duration of drawdowns from previous peaks	46.37%	18.26%	+28.11%

Volatility

CYCN vs. VXRT - Volatility Comparison

The current volatility for Cyclerion Therapeutics, Inc. (CYCN) is 14.24%, while Vaxart, Inc. (VXRT) has a volatility of 22.10%. This indicates that CYCN experiences smaller price fluctuations and is considered to be less risky than VXRT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CYCN	VXRT	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.24%	22.10%	-7.86%
Volatility (6M) Calculated over the trailing 6-month period	154.47%	50.47%	+104.00%
Volatility (1Y) Calculated over the trailing 1-year period	326.92%	87.77%	+239.15%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	229.41%	92.48%	+136.93%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	202.24%	127.94%	+74.30%

Dividends

CYCN vs. VXRT - Dividend Comparison

Neither CYCN nor VXRT has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CYCN and VXRT in my portfolio?

CYCN and VXRT have a correlation of 0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CYCN or VXRT?

VXRT has higher volatility (22.10%) compared to CYCN (14.24%). In terms of maximum drawdown, CYCN dropped -99.72% vs VXRT's -98.71%.

Which has better risk-adjusted returns?

VXRT currently has the higher Sharpe Ratio (0.53 vs 0.09), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.