CVKD vs. AYTU

Last updated Jun 3, 2026

CVKD (Cadrenal Therapeutics Inc. Common Stock) and AYTU (Aytu BioPharma, Inc.) are both stocks. Both are in the Healthcare sector — CVKD in Biotechnology, AYTU in Drug Manufacturers - Specialty & Generic. Over the past 3 years, CVKD returned -40.40%/yr vs 4.89%/yr for AYTU. At a 0.12 correlation, their price movements are largely independent.

Performance

CVKD vs. AYTU - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Cadrenal Therapeutics Inc. Common Stock (CVKD) and Aytu BioPharma, Inc. (AYTU). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CVKD achieves a -35.84% return, which is significantly lower than AYTU's -19.23% return.

CVKD

• 1D: -7.45%
• 1M: -31.50%
• YTD: -35.84%
• 6M: -47.40%
• 1Y: -67.87%
• 3Y*: -40.40%
• 5Y*: —
• 10Y*: —

AYTU

• 1D: -2.33%
• 1M: -19.54%
• YTD: -19.23%
• 6M: 2.44%
• 1Y: 17.98%
• 3Y*: 4.89%
• 5Y*: -54.20%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CVKD vs. AYTU - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023
CVKD Cadrenal Therapeutics Inc. Common Stock	-35.84%	-53.21%	30.56%	-82.04%
AYTU Aytu BioPharma, Inc.	-19.23%	52.94%	-40.14%	-19.77%

Correlation

The correlation between CVKD and AYTU is 0.20, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.20
Correlation (3Y) Calculated over the trailing 3-year period	0.13
Correlation (All Time) Calculated using the full available price history since Jan 23, 2023	0.12

Fundamentals

Market Cap CVKD : $8.67M AYTU : $22.07M
EPS CVKD : -$5.10 AYTU : -$2.91
PB Ratio CVKD : 3.17 AYTU : 0.63
Total Revenue (TTM) CVKD : $0.00 AYTU : $56.60M
Gross Profit (TTM) CVKD : -$5.92K AYTU : $36.14M
EBITDA (TTM) CVKD : -$13.32M AYTU : -$27.34M

Return for Risk

CVKD vs. AYTU — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CVKD

CVKD Risk / Return Rank: 9
CVKD Sharpe Ratio Rank: 12
CVKD Sortino Ratio Rank: 11
CVKD Omega Ratio Rank: 13
CVKD Calmar Ratio Rank: 4
CVKD Martin Ratio Rank: 4

AYTU

AYTU Risk / Return Rank: 52
AYTU Sharpe Ratio Rank: 50
AYTU Sortino Ratio Rank: 51
AYTU Omega Ratio Rank: 51
AYTU Calmar Ratio Rank: 52
AYTU Martin Ratio Rank: 53

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CVKD vs. AYTU - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Cadrenal Therapeutics Inc. Common Stock (CVKD) and Aytu BioPharma, Inc. (AYTU). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CVKD	AYTU	Difference
Sharpe ratio Return per unit of total volatility	-0.69	0.27	-0.96
Sortino ratio Return per unit of downside risk	-0.97	0.92	-1.89
Omega ratio Gain probability vs. loss probability	0.89	1.12	-0.23
Calmar ratio Return relative to maximum drawdown	-0.93	0.51	-1.44
Martin ratio Return relative to average drawdown	-1.56	1.23	-2.78
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CVKD vs. AYTU - Sharpe Ratio Comparison

The current CVKD Sharpe Ratio is -0.69, which is lower than the AYTU Sharpe Ratio of 0.27. The chart below compares the historical Sharpe Ratios of CVKD and AYTU, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CVKD	AYTU	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.69	0.27	-0.96
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.64	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.54	-0.36	-0.18

Drawdowns

CVKD vs. AYTU - Drawdown Comparison

The maximum CVKD drawdown since its inception was -93.12%, smaller than the maximum AYTU drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for CVKD and AYTU.

Drawdown Indicators

	CVKD	AYTU	Difference
Max Drawdown Largest peak-to-trough decline	-93.12%	-100.00%	+6.88%
Max Drawdown (1Y) Largest decline over 1 year	-72.56%	-35.47%	-37.09%
Max Drawdown (3Y) Largest decline over 3 years	-87.41%	-70.24%	-17.17%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.12%	—
Current Drawdown Current decline from peak	-92.96%	-100.00%	+7.04%
Average Drawdown Average peak-to-trough decline	-78.76%	-95.14%	+16.38%
Ulcer Index Depth and duration of drawdowns from previous peaks	43.22%	14.66%	+28.56%

Volatility

CVKD vs. AYTU - Volatility Comparison

Cadrenal Therapeutics Inc. Common Stock (CVKD) has a higher volatility of 17.91% compared to Aytu BioPharma, Inc. (AYTU) at 12.52%. This indicates that CVKD's price experiences larger fluctuations and is considered to be riskier than AYTU based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CVKD	AYTU	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.91%	12.52%	+5.39%
Volatility (6M) Calculated over the trailing 6-month period	81.65%	33.97%	+47.68%
Volatility (1Y) Calculated over the trailing 1-year period	98.78%	66.08%	+32.70%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	101.10%	85.63%	+15.47%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	101.10%	188.35%	-87.25%

Dividends

CVKD vs. AYTU - Dividend Comparison

Neither CVKD nor AYTU has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CVKD and AYTU in my portfolio?

CVKD and AYTU have a correlation of 0.20, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CVKD or AYTU?

CVKD has higher volatility (17.91%) compared to AYTU (12.52%). In terms of maximum drawdown, CVKD dropped -93.12% vs AYTU's -100.00%.

Which has better risk-adjusted returns?

AYTU currently has the higher Sharpe Ratio (0.27 vs -0.69), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.