BIPIX vs. USPIX

Last updated Jun 4, 2026

BIPIX (ProFunds Biotechnology UltraSector Fund) and USPIX (ProFunds UltraShort NASDAQ-100 Fund) are both mutual funds - BIPIX is a Leveraged Equities fund managed by ProFunds, while USPIX is a Inverse Equities fund managed by ProFunds. Over the past 10 years, BIPIX returned 6.09%/yr vs -58.54%/yr for USPIX. At a correlation of -0.65, they often move in opposite directions. BIPIX charges 1.49%/yr vs 1.68%/yr for USPIX.

Performance

BIPIX vs. USPIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ProFunds Biotechnology UltraSector Fund (BIPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BIPIX achieves a 4.28% return, which is significantly higher than USPIX's -32.64% return. Over the past 10 years, BIPIX has outperformed USPIX with an annualized return of 6.09%, while USPIX has yielded a comparatively lower -58.54% annualized return.

BIPIX

• 1D: -6.59%
• 1M: -6.97%
• YTD: 4.28%
• 6M: 4.61%
• 1Y: 83.18%
• 3Y*: 4.78%
• 5Y*: 0.73%
• 10Y*: 6.09%

USPIX

• 1D: -0.93%
• 1M: -18.68%
• YTD: -32.64%
• 6M: -30.56%
• 1Y: -49.42%
• 3Y*: -40.81%
• 5Y*: -34.53%
• 10Y*: -58.54%

*Multi-year figures are annualized to reflect compound growth (CAGR)

BIPIX vs. USPIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
BIPIX ProFunds Biotechnology UltraSector Fund	4.28%	47.99%	-25.91%	9.55%	-13.43%	5.00%	19.94%	23.65%	-12.15%	34.71%
USPIX ProFunds UltraShort NASDAQ-100 Fund	-32.64%	-35.26%	-38.20%	-57.06%	61.80%	-46.20%	-96.36%	-50.15%	-9.56%	-44.56%

Correlation

The correlation between BIPIX and USPIX is -0.44, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.44
Correlation (3Y) Calculated over the trailing 3-year period	-0.46
Correlation (5Y) Calculated over the trailing 5-year period	-0.53
Correlation (10Y) Calculated over the trailing 10-year period	-0.59
Correlation (All Time) Calculated using the full available price history since Jun 20, 2000	-0.65

Over the past year, the inverse relationship between BIPIX and USPIX has weakened: their correlation has moved from -0.65 to -0.44, meaning they move in opposite directions less often than they have historically.

Return for Risk

BIPIX vs. USPIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

BIPIX

BIPIX Risk / Return Rank: 67
BIPIX Sharpe Ratio Rank: 60
BIPIX Sortino Ratio Rank: 49
BIPIX Omega Ratio Rank: 43
BIPIX Calmar Ratio Rank: 95
BIPIX Martin Ratio Rank: 88

USPIX

USPIX Risk / Return Rank: 0
USPIX Sharpe Ratio Rank: 0
USPIX Sortino Ratio Rank: 0
USPIX Omega Ratio Rank: 0
USPIX Calmar Ratio Rank: 0
USPIX Martin Ratio Rank: 0

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

BIPIX vs. USPIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ProFunds Biotechnology UltraSector Fund (BIPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	BIPIX	USPIX	Difference
Sharpe ratio: Return per unit of total volatility	2.28	-1.57	+3.85
Sortino ratio: Return per unit of downside risk	2.96	-2.68	+5.64
Omega ratio: Gain probability vs. loss probability	1.35	0.72	+0.63
Calmar ratio: Return relative to maximum drawdown	5.75	-1.01	+6.76
Martin ratio: Return relative to average drawdown	17.49	-2.01	+19.50
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

BIPIX vs. USPIX - Sharpe Ratio Comparison

The current BIPIX Sharpe Ratio is 2.28, which is higher than the USPIX Sharpe Ratio of -1.57. The chart below compares the historical Sharpe Ratios of BIPIX and USPIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	BIPIX	USPIX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.28	-1.57	+3.85
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.02	-0.77	+0.79
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.17	-1.01	+1.18
Sharpe Ratio (All Time) Calculated using the full available price history	0.15	-0.73	+0.88

Drawdowns

BIPIX vs. USPIX - Drawdown Comparison

The maximum BIPIX drawdown since its inception was -84.51%, smaller than the maximum USPIX drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for BIPIX and USPIX.

Drawdown Indicators

	BIPIX	USPIX	Difference
Max Drawdown Largest peak-to-trough decline	-84.51%	-100.00%	+15.49%
Max Drawdown (1Y) Largest decline over 1 year	-15.15%	-49.97%	+34.82%
Max Drawdown (3Y) Largest decline over 3 years	-59.50%	-80.85%	+21.35%
Max Drawdown (5Y) Largest decline over 5 years	-63.86%	-89.47%	+25.61%
Max Drawdown (10Y) Largest decline over 10 years	-63.86%	-99.99%	+36.13%
Current Drawdown Current decline from peak	-16.45%	-100.00%	+83.55%
Average Drawdown Average peak-to-trough decline	-37.22%	-96.44%	+59.22%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.97%	25.29%	-20.32%

Volatility

BIPIX vs. USPIX - Volatility Comparison

ProFunds Biotechnology UltraSector Fund (BIPIX) has a higher volatility of 14.22% compared to ProFunds UltraShort NASDAQ-100 Fund (USPIX) at 9.07%. This indicates that BIPIX's price experiences larger fluctuations and is considered to be riskier than USPIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BIPIX	USPIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.22%	9.07%	+5.15%
Volatility (6M) Calculated over the trailing 6-month period	30.38%	24.45%	+5.93%
Volatility (1Y) Calculated over the trailing 1-year period	38.37%	32.12%	+6.25%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	39.70%	45.19%	-5.49%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	36.37%	58.07%	-21.70%

BIPIX vs. USPIX - Expense Ratio Comparison

BIPIX has a 1.49% expense ratio, which is lower than USPIX's 1.68% expense ratio.

Dividends

BIPIX vs. USPIX - Dividend Comparison

BIPIX's dividend yield for the trailing twelve months is around 0.35%, less than USPIX's 4.02% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017
BIPIX ProFunds Biotechnology UltraSector Fund	0.35%	0.37%	0.23%	6.69%	0.00%	0.79%	12.09%	3.26%	5.52%	7.19%
USPIX ProFunds UltraShort NASDAQ-100 Fund	4.02%	2.71%	0.00%	5.92%	0.00%	0.00%	0.07%	0.36%	0.00%	0.00%

Frequently Asked Questions

Can I hold both BIPIX and USPIX in my portfolio?

BIPIX and USPIX have a correlation of -0.44, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, BIPIX or USPIX?

BIPIX has higher volatility (14.22%) compared to USPIX (9.07%). In terms of maximum drawdown, BIPIX dropped -84.51% vs USPIX's -100.00%.

Which has better risk-adjusted returns?

BIPIX currently has the higher Sharpe Ratio (2.28 vs -1.57), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.