AXGN vs. STOK

Last updated Jun 4, 2026

AXGN (AxoGen, Inc.) and STOK (Stoke Therapeutics, Inc.) are both stocks. Both are in the Healthcare sector — AXGN in Medical Devices, STOK in Biotechnology. Over the past 5 years, AXGN returned 16.44%/yr vs -4.61%/yr for STOK. At a 0.28 correlation, their price movements are largely independent.

Performance

AXGN vs. STOK - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AxoGen, Inc. (AXGN) and Stoke Therapeutics, Inc. (STOK). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AXGN achieves a 24.14% return, which is significantly higher than STOK's -7.18% return.

AXGN

• 1D: 2.97%
• 1M: -4.69%
• YTD: 24.14%
• 6M: 43.42%
• 1Y: 257.66%
• 3Y*: 66.26%
• 5Y*: 16.44%
• 10Y*: 21.66%

STOK

• 1D: 2.72%
• 1M: -13.81%
• YTD: -7.18%
• 6M: -4.84%
• 1Y: 170.28%
• 3Y*: 34.27%
• 5Y*: -4.61%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

AXGN vs. STOK - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
AXGN AxoGen, Inc.	24.14%	98.60%	141.29%	-31.56%	6.51%	-47.65%	0.06%	-9.78%
STOK Stoke Therapeutics, Inc.	-7.18%	187.76%	109.70%	-43.01%	-61.53%	-61.26%	118.68%	10.75%

Correlation

The correlation between AXGN and STOK is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.22
Correlation (5Y) Calculated over the trailing 5-year period	0.28
Correlation (All Time) Calculated using the full available price history since Jun 20, 2019	0.28

The correlation between AXGN and STOK shifts across timeframes, from 0.12 (1 year) to 0.28 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap AXGN : $2.10B STOK : $1.86B
EPS AXGN : -$0.66 STOK : -$2.85
PS Ratio AXGN : 8.11 STOK : 54.74
PB Ratio AXGN : 8.56 STOK : 4.70
Total Revenue (TTM) AXGN : $238.11M STOK : $32.08M
Gross Profit (TTM) AXGN : $178.61M STOK : $23.81M
EBITDA (TTM) AXGN : $5.69M STOK : -$179.29M

Return for Risk

AXGN vs. STOK — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AXGN

AXGN Risk / Return Rank: 98
AXGN Sharpe Ratio Rank: 98
AXGN Sortino Ratio Rank: 97
AXGN Omega Ratio Rank: 95
AXGN Calmar Ratio Rank: 98
AXGN Martin Ratio Rank: 99

STOK

STOK Risk / Return Rank: 91
STOK Sharpe Ratio Rank: 93
STOK Sortino Ratio Rank: 90
STOK Omega Ratio Rank: 89
STOK Calmar Ratio Rank: 90
STOK Martin Ratio Rank: 92

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AXGN vs. STOK - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AxoGen, Inc. (AXGN) and Stoke Therapeutics, Inc. (STOK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AXGN	STOK	Difference
Sharpe ratio Return per unit of total volatility	4.78	2.66	+2.12
Sortino ratio Return per unit of downside risk	4.92	3.28	+1.63
Omega ratio Gain probability vs. loss probability	1.60	1.41	+0.19
Calmar ratio Return relative to maximum drawdown	13.44	4.61	+8.83
Martin ratio Return relative to average drawdown	43.94	14.14	+29.80
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AXGN vs. STOK - Sharpe Ratio Comparison

The current AXGN Sharpe Ratio is 4.78, which is higher than the STOK Sharpe Ratio of 2.66. The chart below compares the historical Sharpe Ratios of AXGN and STOK, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AXGN	STOK	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	4.78	2.66	+2.12
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.26	-0.06	+0.32
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.35	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.05	0.03	+0.03

Drawdowns

AXGN vs. STOK - Drawdown Comparison

The maximum AXGN drawdown since its inception was -98.49%, roughly equal to the maximum STOK drawdown of -95.17%. Use the drawdown chart below to compare losses from any high point for AXGN and STOK.

Drawdown Indicators

	AXGN	STOK	Difference
Max Drawdown Largest peak-to-trough decline	-98.49%	-95.17%	-3.32%
Max Drawdown (1Y) Largest decline over 1 year	-19.30%	-37.16%	+17.86%
Max Drawdown (3Y) Largest decline over 3 years	-62.36%	-75.62%	+13.26%
Max Drawdown (5Y) Largest decline over 5 years	-83.69%	-91.80%	+8.11%
Max Drawdown (10Y) Largest decline over 10 years	-93.54%	—	—
Current Drawdown Current decline from peak	-27.32%	-57.80%	+30.48%
Average Drawdown Average peak-to-trough decline	-64.90%	-62.31%	-2.59%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.25%	12.09%	-5.84%

Volatility

AXGN vs. STOK - Volatility Comparison

The current volatility for AxoGen, Inc. (AXGN) is 9.77%, while Stoke Therapeutics, Inc. (STOK) has a volatility of 12.34%. This indicates that AXGN experiences smaller price fluctuations and is considered to be less risky than STOK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AXGN	STOK	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.77%	12.34%	-2.57%
Volatility (6M) Calculated over the trailing 6-month period	37.39%	41.46%	-4.07%
Volatility (1Y) Calculated over the trailing 1-year period	54.34%	65.08%	-10.74%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	64.09%	80.88%	-16.79%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	62.05%	80.43%	-18.38%

Dividends

AXGN vs. STOK - Dividend Comparison

Neither AXGN nor STOK has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both AXGN and STOK in my portfolio?

AXGN and STOK have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AXGN or STOK?

STOK has higher volatility (12.34%) compared to AXGN (9.77%). In terms of maximum drawdown, AXGN dropped -98.49% vs STOK's -95.17%.

Which has better risk-adjusted returns?

AXGN currently has the higher Sharpe Ratio (4.78 vs 2.66), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.