ALXO vs. OPEN

Last updated Jun 4, 2026

ALXO (ALX Oncology Holdings Inc.) and OPEN (Opendoor Technologies Inc.) are both stocks. ALXO operates in Biotechnology (Healthcare), while OPEN operates in Real Estate - Services (Real Estate). Over the past 5 years, ALXO returned -50.26%/yr vs -21.02%/yr for OPEN. At a 0.24 correlation, their price movements are largely independent.

Performance

ALXO vs. OPEN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ALX Oncology Holdings Inc. (ALXO) and Opendoor Technologies Inc. (OPEN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ALXO achieves a 47.79% return, which is significantly higher than OPEN's -16.47% return.

ALXO

• 1D: -6.18%
• 1M: -11.17%
• YTD: 47.79%
• 6M: 26.52%
• 1Y: 201.06%
• 3Y*: -41.45%
• 5Y*: -50.26%
• 10Y*: —

OPEN

• 1D: -9.98%
• 1M: -5.07%
• YTD: -16.47%
• 6M: -29.83%
• 1Y: 751.93%
• 3Y*: 26.60%
• 5Y*: -21.02%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

ALXO vs. OPEN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
ALXO ALX Oncology Holdings Inc.	47.79%	-32.34%	-88.78%	32.12%	-47.56%	-75.07%	187.33%
OPEN Opendoor Technologies Inc.	-16.47%	276.52%	-64.29%	286.21%	-92.06%	-35.72%	89.42%

Correlation

The correlation between ALXO and OPEN is 0.10, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.10
Correlation (3Y) Calculated over the trailing 3-year period	0.17
Correlation (5Y) Calculated over the trailing 5-year period	0.24
Correlation (All Time) Calculated using the full available price history since Jul 20, 2020	0.24

The correlation between ALXO and OPEN shifts across timeframes, from 0.10 (1 year) to 0.24 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap ALXO : $174.64M OPEN : $4.67B
EPS ALXO : -$1.34 OPEN : -$1.74
PB Ratio ALXO : 1.15 OPEN : 4.90
Total Revenue (TTM) ALXO : $0.00 OPEN : $3.94B
Gross Profit (TTM) ALXO : $0.00 OPEN : $312.00M
EBITDA (TTM) ALXO : -$88.92M OPEN : -$1.25B

Return for Risk

ALXO vs. OPEN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ALXO

ALXO Risk / Return Rank: 84
ALXO Sharpe Ratio Rank: 85
ALXO Sortino Ratio Rank: 86
ALXO Omega Ratio Rank: 80
ALXO Calmar Ratio Rank: 88
ALXO Martin Ratio Rank: 84

OPEN

OPEN Risk / Return Rank: 96
OPEN Sharpe Ratio Rank: 98
OPEN Sortino Ratio Rank: 96
OPEN Omega Ratio Rank: 93
OPEN Calmar Ratio Rank: 98
OPEN Martin Ratio Rank: 95

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ALXO vs. OPEN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ALX Oncology Holdings Inc. (ALXO) and Opendoor Technologies Inc. (OPEN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ALXO	OPEN	Difference
Sharpe ratio: Return per unit of total volatility	1.75	4.73	-2.99
Sortino ratio: Return per unit of downside risk	2.76	4.44	-1.68
Omega ratio: Gain probability vs. loss probability	1.31	1.52	-0.21
Calmar ratio: Return relative to maximum drawdown	4.01	13.10	-9.09
Martin ratio: Return relative to average drawdown	8.05	20.51	-12.46
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ALXO vs. OPEN - Sharpe Ratio Comparison

The current ALXO Sharpe Ratio is 1.75, which is lower than the OPEN Sharpe Ratio of 4.73. The chart below compares the historical Sharpe Ratios of ALXO and OPEN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ALXO	OPEN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.75	4.73	-2.99
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.51	-0.19	-0.32
Sharpe Ratio (All Time) Calculated using the full available price history	-0.40	-0.11	-0.29

Drawdowns

ALXO vs. OPEN - Drawdown Comparison

The maximum ALXO drawdown since its inception was -99.64%, roughly equal to the maximum OPEN drawdown of -98.57%. Use the drawdown chart below to compare losses from any high point for ALXO and OPEN.

Drawdown Indicators

	ALXO	OPEN	Difference
Max Drawdown Largest peak-to-trough decline	-99.64%	-98.57%	-1.07%
Max Drawdown (1Y) Largest decline over 1 year	-50.46%	-57.96%	+7.50%
Max Drawdown (3Y) Largest decline over 3 years	-97.69%	-90.28%	-7.41%
Max Drawdown (5Y) Largest decline over 5 years	-99.50%	-97.93%	-1.57%
Current Drawdown Current decline from peak	-98.51%	-85.97%	-12.54%
Average Drawdown Average peak-to-trough decline	-79.13%	-74.57%	-4.56%
Ulcer Index Depth and duration of drawdowns from previous peaks	25.08%	36.94%	-11.86%

Volatility

ALXO vs. OPEN - Volatility Comparison

ALX Oncology Holdings Inc. (ALXO) has a higher volatility of 20.74% compared to Opendoor Technologies Inc. (OPEN) at 19.07%. This indicates that ALXO's price experiences larger fluctuations and is considered to be riskier than OPEN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ALXO	OPEN	Difference
Volatility (1M) Calculated over the trailing 1-month period	20.74%	19.07%	+1.67%
Volatility (6M) Calculated over the trailing 6-month period	61.67%	52.34%	+9.33%
Volatility (1Y) Calculated over the trailing 1-year period	115.82%	160.45%	-44.63%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	99.42%	113.43%	-14.01%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	98.60%	110.47%	-11.87%

Dividends

ALXO vs. OPEN - Dividend Comparison

Neither ALXO nor OPEN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ALXO and OPEN in my portfolio?

ALXO and OPEN have a correlation of 0.10, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ALXO or OPEN?

ALXO has higher volatility (20.74%) compared to OPEN (19.07%). In terms of maximum drawdown, ALXO dropped -99.64% vs OPEN's -98.57%.

Which has better risk-adjusted returns?

OPEN currently has the higher Sharpe Ratio (4.73 vs 1.75), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.