AGEN vs. SPY

Last updated Jun 24, 2026

AGEN (Agenus Inc.) is a stock, while SPY (State Street SPDR S&P 500 ETF) is S&P 500 fund tracking the S&P 500 Index. Over the past 10 years, AGEN returned -27.52%/yr vs 15.53%/yr for SPY. At a 0.31 correlation, their price movements are largely independent.

Performance

AGEN vs. SPY - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Agenus Inc. (AGEN) and State Street SPDR S&P 500 ETF (SPY). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AGEN achieves a -2.23% return, which is significantly lower than SPY's 8.15% return. Over the past 10 years, AGEN has underperformed SPY with an annualized return of -27.52%, while SPY has yielded a comparatively higher 15.53% annualized return.

AGEN

• 1D: 0.99%
• 1M: -1.29%
• YTD: -2.23%
• 6M: -7.25%
• 1Y: -36.04%
• 3Y*: -55.40%
• 5Y*: -50.84%
• 10Y*: -27.52%

SPY

• 1D: -1.45%
• 1M: -1.36%
• YTD: 8.15%
• 6M: 7.20%
• 1Y: 23.59%
• 3Y*: 20.68%
• 5Y*: 13.05%
• 10Y*: 15.53%

*Multi-year figures are annualized to reflect compound growth (CAGR)

AGEN vs. SPY - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AGEN Agenus Inc.	-2.23%	14.60%	-83.45%	-64.85%	-25.47%	1.26%	-21.87%	71.01%	-26.99%	-20.87%
SPY State Street SPDR S&P 500 ETF	8.15%	17.72%	24.89%	26.18%	-18.18%	28.73%	18.33%	31.22%	-4.57%	21.71%

Correlation

The correlation between AGEN and SPY is 0.37, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.37
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.36
Correlation (10Y) Calculated over the trailing 10-year period	0.33
Correlation (All Time) Calculated using the full available price history since Feb 8, 2000	0.31

Return for Risk

AGEN vs. SPY — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AGEN

AGEN Risk / Return Rank: 26
AGEN Sharpe Ratio Rank: 24
AGEN Sortino Ratio Rank: 28
AGEN Omega Ratio Rank: 29
AGEN Calmar Ratio Rank: 21
AGEN Martin Ratio Rank: 27

SPY

SPY Risk / Return Rank: 59
SPY Sharpe Ratio Rank: 58
SPY Sortino Ratio Rank: 56
SPY Omega Ratio Rank: 57
SPY Calmar Ratio Rank: 56
SPY Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AGEN vs. SPY - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Agenus Inc. (AGEN) and State Street SPDR S&P 500 ETF (SPY). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	AGEN	SPY	Difference
Sharpe ratio: Return per unit of total volatility	-0.42	1.90	-2.32
Sortino ratio: Return per unit of downside risk	-0.14	2.58	-2.72
Omega ratio: Gain probability vs. loss probability	0.98	1.34	-0.36
Calmar ratio: Return relative to maximum drawdown	-0.60	2.67	-3.26
Martin ratio: Return relative to average drawdown	-0.82	11.92	-12.74

AGEN vs. SPY - Sharpe Ratio Comparison

The current AGEN Sharpe Ratio is -0.42, which is lower than the SPY Sharpe Ratio of 1.90. The chart below compares the historical Sharpe Ratios of AGEN and SPY, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

AGEN vs. SPY - Drawdown Comparison

The maximum AGEN drawdown since its inception was -99.98%, which is greater than SPY's maximum drawdown of -55.19%. Use the drawdown chart below to compare losses from any high point for AGEN and SPY.

Drawdown Indicators

	AGEN	SPY	Difference
Max Drawdown Largest peak-to-trough decline	-99.98%	-55.19%	-44.79%
Max Drawdown (1Y) Largest decline over 1 year	-60.76%	-8.88%	-51.88%
Max Drawdown (3Y) Largest decline over 3 years	-96.00%	-18.76%	-77.24%
Max Drawdown (5Y) Largest decline over 5 years	-98.84%	-24.50%	-74.34%
Max Drawdown (10Y) Largest decline over 10 years	-98.96%	-33.72%	-65.24%
Current Drawdown Current decline from peak	-99.95%	-3.17%	-96.78%
Average Drawdown Average peak-to-trough decline	-93.68%	-9.04%	-84.64%
Ulcer Index Depth and duration of drawdowns from previous peaks	44.21%	1.98%	+42.23%

Volatility

AGEN vs. SPY - Volatility Comparison

Agenus Inc. (AGEN) has a higher volatility of 19.01% compared to State Street SPDR S&P 500 ETF (SPY) at 4.87%. This indicates that AGEN's price experiences larger fluctuations and is considered to be riskier than SPY based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AGEN	SPY	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.01%	4.87%	+14.14%
Volatility (6M) Calculated over the trailing 6-month period	63.50%	9.85%	+53.65%
Volatility (1Y) Calculated over the trailing 1-year period	85.78%	12.50%	+73.28%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	95.89%	17.15%	+78.74%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	83.38%	17.95%	+65.43%

Dividends

AGEN vs. SPY - Dividend Comparison

AGEN has not paid dividends to shareholders, while SPY's dividend yield for the trailing twelve months is around 1.03%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AGEN Agenus Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
SPY State Street SPDR S&P 500 ETF	1.03%	1.07%	1.21%	1.40%	1.65%	1.20%	1.52%	1.75%	2.04%	1.80%	2.03%	2.06%

Frequently Asked Questions

Can I hold both AGEN and SPY in my portfolio?

AGEN and SPY have a correlation of 0.37, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AGEN or SPY?

AGEN has higher volatility (19.01%) compared to SPY (4.87%). In terms of maximum drawdown, AGEN dropped -99.98% vs SPY's -55.19%.

Which has better risk-adjusted returns?

SPY currently has the higher Sharpe Ratio (1.90 vs -0.42), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.