ACRV vs. VTGN

Last updated Aug 1, 2026

ACRV (Acrivon Therapeutics Inc. Common Stock) and VTGN (VistaGen Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, ACRV returned -50.62%/yr vs -48.84%/yr for VTGN. Their 0.24 correlation means their historical movements had little consistent relationship.

Performance

ACRV vs. VTGN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Acrivon Therapeutics Inc. Common Stock (ACRV) and VistaGen Therapeutics, Inc. (VTGN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACRV achieves a -37.76% return, which is significantly higher than VTGN's -63.59% return.

ACRV

• 1D: -1.32%
• 1M: -12.79%
• 6M: -16.20%
• YTD: -37.76%
• 1Y: 19.05%
• 3Y*: -50.62%
• 5Y*: —
• 10Y*: —
• ALL TIME*: -44.55%

VTGN

• 1D: 0.00%
• 1M: -3.17%
• 6M: -56.83%
• YTD: -63.59%
• 1Y: -91.75%
• 3Y*: -48.84%
• 5Y*: -68.67%
• 10Y*: -44.44%
• ALL TIME*: -48.39%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ACRV Acrivon Therapeutics Inc. Common Stock	$467.58K	$869.81K	$779.27K
VTGN VistaGen Therapeutics, Inc.	$201.44K	$332.74K	$731.92K

ACRV vs. VTGN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
ACRV Acrivon Therapeutics Inc. Common Stock	-37.76%	-59.97%	22.36%	-57.29%	-13.71%
VTGN VistaGen Therapeutics, Inc.	-63.59%	-77.56%	-42.61%	66.34%	-32.68%

Correlation

The correlation between ACRV and VTGN is 0.23, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.23
Correlation (3Y) Balances recent behavior with more history.	0.26
Correlation (All Time) Calculated using the full available price history since Nov 15, 2022	0.24

Fundamentals

Market Cap ACRV : $64.20M VTGN : $9.89M
EPS ACRV : -$2.00 VTGN : -$1.80
PB Ratio ACRV : 0.61 VTGN : 0.26
Total Revenue (TTM) ACRV : $0.00 VTGN : $1.27M
Gross Profit (TTM) ACRV : $311.00K VTGN : $522.00K
EBITDA (TTM) ACRV : -$84.65M VTGN : -$68.97M

Return for Risk

ACRV vs. VTGN — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ACRV

ACRV Risk / Return Rank: 54
ACRV Sharpe Ratio Rank: 51
ACRV Sortino Ratio Rank: 58
ACRV Omega Ratio Rank: 58
ACRV Calmar Ratio Rank: 53
ACRV Martin Ratio Rank: 51

VTGN

VTGN Risk / Return Rank: 11
VTGN Sharpe Ratio Rank: 13
VTGN Sortino Ratio Rank: 17
VTGN Omega Ratio Rank: 10
VTGN Calmar Ratio Rank: 4
VTGN Martin Ratio Rank: 11

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ACRV vs. VTGN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Acrivon Therapeutics Inc. Common Stock (ACRV) and VistaGen Therapeutics, Inc. (VTGN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ACRV	VTGN	Difference
Sharpe ratio: Return per unit of total volatility	0.18	-0.69	+0.88
Sortino ratio: Return per unit of downside risk	1.00	-0.72	+1.72
Omega ratio: Gain probability vs. loss probability	1.13	0.85	+0.28
Calmar ratio: Return relative to maximum drawdown	0.30	-0.96	+1.26
Martin ratio: Return relative to average drawdown	0.52	-1.31	+1.83

ACRV vs. VTGN - Sharpe Ratio Comparison

The current ACRV Sharpe Ratio is 0.18, which is higher than the VTGN Sharpe Ratio of -0.69. The chart below compares the historical Sharpe Ratios of ACRV and VTGN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ACRV vs. VTGN - Drawdown Comparison

The maximum ACRV drawdown since its inception was -95.47%, roughly equal to the maximum VTGN drawdown of -99.89%. Use the drawdown chart below to compare losses from any high point for ACRV and VTGN.

Drawdown Indicators

	ACRV	VTGN	Difference
Max Drawdown Largest peak-to-trough decline	-95.47%	-99.89%	+4.42%
Max Drawdown (1Y) Largest decline over 1 year	-57.14%	-95.39%	+38.25%
Max Drawdown (3Y) Largest decline over 3 years	-91.53%	-98.27%	+6.74%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.76%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-99.83%	—
Current Drawdown Current decline from peak	-93.53%	-99.89%	+6.36%
Average Drawdown Average peak-to-trough decline	-71.30%	-84.64%	+13.34%
Ulcer Index Depth and duration of drawdowns from previous peaks	33.25%	69.71%	-36.46%

Volatility

ACRV vs. VTGN - Volatility Comparison

Acrivon Therapeutics Inc. Common Stock (ACRV) has a higher volatility of 23.22% compared to VistaGen Therapeutics, Inc. (VTGN) at 12.80%. This indicates that ACRV's price experiences larger fluctuations and is considered to be riskier than VTGN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACRV	VTGN	Difference
Volatility (1M) Calculated over the trailing 1-month period	23.22%	12.80%	+10.42%
Volatility (6M) Calculated over the trailing 6-month period	53.21%	131.72%	-78.51%
Volatility (1Y) Calculated over the trailing 1-year period	93.40%	132.16%	-38.76%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	103.36%	321.80%	-218.44%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	103.36%	241.03%	-137.67%

Dividends

ACRV vs. VTGN - Dividend Comparison

Neither ACRV nor VTGN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACRV and VTGN in my portfolio?

ACRV and VTGN have a correlation of 0.23, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACRV or VTGN?

ACRV has higher volatility (23.22%) compared to VTGN (12.80%). In terms of maximum drawdown, ACRV dropped -95.47% vs VTGN's -99.89%.

Which has better risk-adjusted returns?

ACRV currently has the higher Sharpe Ratio (0.18 vs -0.69), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.