ACRV vs. VTGN

Last updated Jun 3, 2026

ACRV (Acrivon Therapeutics Inc. Common Stock) and VTGN (VistaGen Therapeutics, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, ACRV returned -49.75%/yr vs -47.37%/yr for VTGN. At a 0.25 correlation, their price movements are largely independent.

Performance

ACRV vs. VTGN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Acrivon Therapeutics Inc. Common Stock (ACRV) and VistaGen Therapeutics, Inc. (VTGN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACRV achieves a -34.85% return, which is significantly lower than VTGN's -12.37% return.

ACRV

• 1D: 0.64%
• 1M: -24.88%
• YTD: -34.85%
• 6M: -28.64%
• 1Y: 41.44%
• 3Y*: -49.75%
• 5Y*: —
• 10Y*: —

VTGN

• 1D: -10.42%
• 1M: -7.32%
• YTD: -12.37%
• 6M: -83.89%
• 1Y: -76.08%
• 3Y*: -47.37%
• 5Y*: -61.81%
• 10Y*: -41.10%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ACRV vs. VTGN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
ACRV Acrivon Therapeutics Inc. Common Stock	-34.85%	-59.97%	22.36%	-57.29%	-30.77%
VTGN VistaGen Therapeutics, Inc.	-12.37%	-77.56%	-42.61%	66.34%	-35.26%

Correlation

The correlation between ACRV and VTGN is 0.29, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.29
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (All Time) Calculated using the full available price history since Nov 16, 2022	0.25

Fundamentals

Market Cap ACRV : $60.80M VTGN : $24.50M
EPS ACRV : -$2.00 VTGN : -$1.83
PB Ratio ACRV : 0.64 VTGN : 0.48
Total Revenue (TTM) ACRV : $0.00 VTGN : $790.00K
Gross Profit (TTM) ACRV : $311.00K VTGN : $318.00K
EBITDA (TTM) ACRV : -$84.65M VTGN : -$68.03M

Return for Risk

ACRV vs. VTGN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ACRV

ACRV Risk / Return Rank: 58
ACRV Sharpe Ratio Rank: 56
ACRV Sortino Ratio Rank: 61
ACRV Omega Ratio Rank: 60
ACRV Calmar Ratio Rank: 58
ACRV Martin Ratio Rank: 57

VTGN

VTGN Risk / Return Rank: 14
VTGN Sharpe Ratio Rank: 12
VTGN Sortino Ratio Rank: 22
VTGN Omega Ratio Rank: 19
VTGN Calmar Ratio Rank: 7
VTGN Martin Ratio Rank: 10

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ACRV vs. VTGN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Acrivon Therapeutics Inc. Common Stock (ACRV) and VistaGen Therapeutics, Inc. (VTGN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	ACRV	VTGN	Difference
Sharpe ratio Return per unit of total volatility	0.45	-0.68	+1.13
Sortino ratio Return per unit of downside risk	1.32	-0.33	+1.65
Omega ratio Gain probability vs. loss probability	1.17	0.94	+0.23
Calmar ratio Return relative to maximum drawdown	0.87	-0.86	+1.73
Martin ratio Return relative to average drawdown	1.77	-1.31	+3.08
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

ACRV vs. VTGN - Sharpe Ratio Comparison

The current ACRV Sharpe Ratio is 0.45, which is higher than the VTGN Sharpe Ratio of -0.68. The chart below compares the historical Sharpe Ratios of ACRV and VTGN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	ACRV	VTGN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.45	-0.68	+1.13
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	-0.19	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.17	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.47	-0.19	-0.29

Drawdowns

ACRV vs. VTGN - Drawdown Comparison

The maximum ACRV drawdown since its inception was -95.47%, roughly equal to the maximum VTGN drawdown of -99.76%. Use the drawdown chart below to compare losses from any high point for ACRV and VTGN.

Drawdown Indicators

	ACRV	VTGN	Difference
Max Drawdown Largest peak-to-trough decline	-95.47%	-99.76%	+4.29%
Max Drawdown (1Y) Largest decline over 1 year	-57.14%	-89.69%	+32.55%
Max Drawdown (3Y) Largest decline over 3 years	-92.31%	-96.13%	+3.82%
Max Drawdown (5Y) Largest decline over 5 years	—	-99.51%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-99.62%	—
Current Drawdown Current decline from peak	-93.23%	-99.72%	+6.49%
Average Drawdown Average peak-to-trough decline	-70.39%	-84.43%	+14.04%
Ulcer Index Depth and duration of drawdowns from previous peaks	28.03%	59.20%	-31.17%

Volatility

ACRV vs. VTGN - Volatility Comparison

The current volatility for Acrivon Therapeutics Inc. Common Stock (ACRV) is 17.27%, while VistaGen Therapeutics, Inc. (VTGN) has a volatility of 21.72%. This indicates that ACRV experiences smaller price fluctuations and is considered to be less risky than VTGN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACRV	VTGN	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.27%	21.72%	-4.45%
Volatility (6M) Calculated over the trailing 6-month period	73.74%	171.65%	-97.91%
Volatility (1Y) Calculated over the trailing 1-year period	92.51%	111.75%	-19.24%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	103.93%	320.16%	-216.23%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	103.93%	240.05%	-136.12%

Dividends

ACRV vs. VTGN - Dividend Comparison

Neither ACRV nor VTGN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACRV and VTGN in my portfolio?

ACRV and VTGN have a correlation of 0.29, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACRV or VTGN?

VTGN has higher volatility (21.72%) compared to ACRV (17.27%). In terms of maximum drawdown, ACRV dropped -95.47% vs VTGN's -99.76%.

Which has better risk-adjusted returns?

ACRV currently has the higher Sharpe Ratio (0.45 vs -0.68), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.