ACIU vs. AMZN

Last updated Aug 1, 2026

ACIU (AC Immune SA) and AMZN (Amazon.com, Inc) are both stocks. ACIU operates in Biotechnology (Healthcare), while AMZN operates in Internet Retail (Consumer Cyclical). Over the past 5 years, ACIU returned -21.36%/yr vs 10.30%/yr for AMZN. Their 0.18 correlation means their historical movements had little consistent relationship.

Performance

ACIU vs. AMZN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AC Immune SA (ACIU) and Amazon.com, Inc (AMZN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACIU achieves a -30.25% return, which is significantly lower than AMZN's 17.66% return.

ACIU

• 1D: -7.59%
• 1M: -12.75%
• 6M: -31.35%
• YTD: -30.25%
• 1Y: 3.30%
• 3Y*: -9.14%
• 5Y*: -21.36%
• 10Y*: —
• ALL TIME*: -17.23%

AMZN

• 1D: 15.32%
• 1M: 11.91%
• 6M: 13.49%
• YTD: 17.66%
• 1Y: 26.46%
• 3Y*: 27.29%
• 5Y*: 10.30%
• 10Y*: 21.72%
• ALL TIME*: 30.20%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
ACIU AC Immune SA	$404.16K	$481.11K	$674.22K
AMZN Amazon.com, Inc	$13.00B	$11.21B	$12.30B

ACIU vs. AMZN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ACIU AC Immune SA	-30.25%	16.30%	-46.00%	145.10%	-58.79%	-4.26%	-39.32%	-9.84%	-26.17%	-1.39%
AMZN Amazon.com, Inc	17.66%	5.21%	44.39%	80.88%	-49.62%	2.38%	76.26%	23.03%	28.43%	55.96%

Correlation

The correlation between ACIU and AMZN is 0.15, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.15
Correlation (3Y) Balances recent behavior with more history.	0.14
Correlation (5Y) Shows whether the relationship held over a longer period.	0.22
Correlation (All Time) Calculated using the full available price history since Sep 23, 2016	0.18

Fundamentals

Market Cap ACIU : $222.88M AMZN : $2.92T
EPS ACIU : -CHF 0.66 AMZN : $12.44
PS Ratio ACIU : 47.56 AMZN : 3.81
PB Ratio ACIU : 5.53 AMZN : 5.37
Total Revenue (TTM) ACIU : CHF 3.70M AMZN : $775.68B
Gross Profit (TTM) ACIU : CHF 3.70M AMZN : $393.81B
EBITDA (TTM) ACIU : -CHF 64.45M AMZN : $254.00B

Return for Risk

ACIU vs. AMZN — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

ACIU

ACIU Risk / Return Rank: 46
ACIU Sharpe Ratio Rank: 45
ACIU Sortino Ratio Rank: 49
ACIU Omega Ratio Rank: 48
ACIU Calmar Ratio Rank: 45
ACIU Martin Ratio Rank: 45

AMZN

AMZN Risk / Return Rank: 60
AMZN Sharpe Ratio Rank: 62
AMZN Sortino Ratio Rank: 58
AMZN Omega Ratio Rank: 56
AMZN Calmar Ratio Rank: 62
AMZN Martin Ratio Rank: 61

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

ACIU vs. AMZN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AC Immune SA (ACIU) and Amazon.com, Inc (AMZN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ACIU	AMZN	Difference
Sharpe ratio: Return per unit of total volatility	0.02	0.46	-0.44
Sortino ratio: Return per unit of downside risk	0.62	0.94	-0.33
Omega ratio: Gain probability vs. loss probability	1.07	1.11	-0.04
Calmar ratio: Return relative to maximum drawdown	0.03	0.74	-0.71
Martin ratio: Return relative to average drawdown	0.05	1.58	-1.52

ACIU vs. AMZN - Sharpe Ratio Comparison

The current ACIU Sharpe Ratio is 0.02, which is lower than the AMZN Sharpe Ratio of 0.46. The chart below compares the historical Sharpe Ratios of ACIU and AMZN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ACIU vs. AMZN - Drawdown Comparison

The maximum ACIU drawdown since its inception was -92.33%, roughly equal to the maximum AMZN drawdown of -94.40%. Use the drawdown chart below to compare losses from any high point for ACIU and AMZN.

Drawdown Indicators

	ACIU	AMZN	Difference
Max Drawdown Largest peak-to-trough decline	-92.33%	-94.40%	+2.07%
Max Drawdown (1Y) Largest decline over 1 year	-46.87%	-21.74%	-25.13%
Max Drawdown (3Y) Largest decline over 3 years	-70.40%	-30.88%	-39.52%
Max Drawdown (5Y) Largest decline over 5 years	-81.80%	-55.73%	-26.07%
Max Drawdown (10Y) Largest decline over 10 years	—	-56.15%	—
Current Drawdown Current decline from peak	-88.65%	-1.24%	-87.41%
Average Drawdown Average peak-to-trough decline	-69.65%	-28.11%	-41.54%
Ulcer Index Depth and duration of drawdowns from previous peaks	25.88%	10.26%	+15.62%

Volatility

ACIU vs. AMZN - Volatility Comparison

AC Immune SA (ACIU) has a higher volatility of 17.58% compared to Amazon.com, Inc (AMZN) at 16.52%. This indicates that ACIU's price experiences larger fluctuations and is considered to be riskier than AMZN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACIU	AMZN	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.58%	16.52%	+1.06%
Volatility (6M) Calculated over the trailing 6-month period	45.27%	26.50%	+18.77%
Volatility (1Y) Calculated over the trailing 1-year period	77.35%	35.20%	+42.15%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	78.41%	36.27%	+42.14%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	79.34%	33.00%	+46.34%

Dividends

ACIU vs. AMZN - Dividend Comparison

Neither ACIU nor AMZN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACIU and AMZN in my portfolio?

ACIU and AMZN have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACIU or AMZN?

ACIU has higher volatility (17.58%) compared to AMZN (16.52%). In terms of maximum drawdown, ACIU dropped -92.33% vs AMZN's -94.40%.

Which has better risk-adjusted returns?

AMZN currently has the higher Sharpe Ratio (0.46 vs 0.02), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.