ACIU vs. AMZN

Last updated Jul 14, 2026

ACIU (AC Immune SA) and AMZN (Amazon.com, Inc) are both stocks. ACIU operates in Biotechnology (Healthcare), while AMZN operates in Internet Retail (Consumer Cyclical). Over the past 5 years, ACIU returned -20.28%/yr vs 6.08%/yr for AMZN. At a 0.18 correlation, their price movements are largely independent.

Performance

ACIU vs. AMZN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in AC Immune SA (ACIU) and Amazon.com, Inc (AMZN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, ACIU achieves a -21.97% return, which is significantly lower than AMZN's 7.14% return.

ACIU

• 1D: 2.51%
• 1M: 6.06%
• 6M: -30.40%
• YTD: -21.97%
• 1Y: 20.10%
• 3Y*: -6.94%
• 5Y*: -20.28%
• 10Y*: —

AMZN

• 1D: 0.80%
• 1M: 3.67%
• 6M: 0.34%
• YTD: 7.14%
• 1Y: 9.91%
• 3Y*: 22.46%
• 5Y*: 6.08%
• 10Y*: 21.00%

*Multi-year figures are annualized to reflect compound growth (CAGR)

ACIU vs. AMZN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ACIU AC Immune SA	-21.97%	16.30%	-46.00%	145.10%	-58.79%	-4.26%	-39.32%	-9.84%	-26.17%	-1.39%
AMZN Amazon.com, Inc	7.14%	5.21%	44.39%	80.88%	-49.62%	2.38%	76.26%	23.03%	28.43%	55.96%

Correlation

The correlation between ACIU and AMZN is 0.14, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.15
Correlation (3Y) Calculated over the trailing 3-year period	0.14
Correlation (5Y) Calculated over the trailing 5-year period	0.22
Correlation (All Time) Calculated using the full available price history since Sep 23, 2016	0.18

Fundamentals

Market Cap ACIU : $249.35M AMZN : $2.66T
EPS ACIU : -CHF 0.66 AMZN : $8.36
PS Ratio ACIU : 53.71 AMZN : 3.62
PB Ratio ACIU : 6.24 AMZN : 6.09
Total Revenue (TTM) ACIU : CHF 3.70M AMZN : $742.78B
Gross Profit (TTM) ACIU : CHF 3.70M AMZN : $348.59B
EBITDA (TTM) ACIU : -CHF 64.45M AMZN : $152.71B

Return for Risk

ACIU vs. AMZN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

ACIU

ACIU Risk / Return Rank: 56
ACIU Sharpe Ratio Rank: 55
ACIU Sortino Ratio Rank: 58
ACIU Omega Ratio Rank: 56
ACIU Calmar Ratio Rank: 56
ACIU Martin Ratio Rank: 56

AMZN

AMZN Risk / Return Rank: 54
AMZN Sharpe Ratio Rank: 57
AMZN Sortino Ratio Rank: 51
AMZN Omega Ratio Rank: 50
AMZN Calmar Ratio Rank: 57
AMZN Martin Ratio Rank: 57

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ACIU vs. AMZN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for AC Immune SA (ACIU) and Amazon.com, Inc (AMZN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	ACIU	AMZN	Difference
Sharpe ratio: Return per unit of total volatility	0.26	0.32	-0.06
Sortino ratio: Return per unit of downside risk	0.98	0.66	+0.31
Omega ratio: Gain probability vs. loss probability	1.11	1.08	+0.03
Calmar ratio: Return relative to maximum drawdown	0.43	0.46	-0.03
Martin ratio: Return relative to average drawdown	0.84	1.01	-0.17

ACIU vs. AMZN - Sharpe Ratio Comparison

The current ACIU Sharpe Ratio is 0.26, which is comparable to the AMZN Sharpe Ratio of 0.32. The chart below compares the historical Sharpe Ratios of ACIU and AMZN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

ACIU vs. AMZN - Drawdown Comparison

The maximum ACIU drawdown since its inception was -92.33%, roughly equal to the maximum AMZN drawdown of -94.40%. Use the drawdown chart below to compare losses from any high point for ACIU and AMZN.

Drawdown Indicators

	ACIU	AMZN	Difference
Max Drawdown Largest peak-to-trough decline	-92.33%	-94.40%	+2.07%
Max Drawdown (1Y) Largest decline over 1 year	-46.87%	-21.74%	-25.13%
Max Drawdown (3Y) Largest decline over 3 years	-70.40%	-30.88%	-39.52%
Max Drawdown (5Y) Largest decline over 5 years	-81.80%	-55.77%	-26.03%
Max Drawdown (10Y) Largest decline over 10 years	—	-56.15%	—
Current Drawdown Current decline from peak	-87.31%	-10.07%	-77.24%
Average Drawdown Average peak-to-trough decline	-69.54%	-28.15%	-41.39%
Ulcer Index Depth and duration of drawdowns from previous peaks	23.86%	9.84%	+14.02%

Volatility

ACIU vs. AMZN - Volatility Comparison

AC Immune SA (ACIU) has a higher volatility of 19.67% compared to Amazon.com, Inc (AMZN) at 9.75%. This indicates that ACIU's price experiences larger fluctuations and is considered to be riskier than AMZN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	ACIU	AMZN	Difference
Volatility (1M) Calculated over the trailing 1-month period	19.67%	9.75%	+9.92%
Volatility (6M) Calculated over the trailing 6-month period	45.34%	21.80%	+23.54%
Volatility (1Y) Calculated over the trailing 1-year period	77.68%	30.99%	+46.69%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	78.33%	35.68%	+42.65%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	79.45%	32.59%	+46.86%

Dividends

ACIU vs. AMZN - Dividend Comparison

Neither ACIU nor AMZN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both ACIU and AMZN in my portfolio?

ACIU and AMZN have a correlation of 0.14, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, ACIU or AMZN?

ACIU has higher volatility (19.67%) compared to AMZN (9.75%). In terms of maximum drawdown, ACIU dropped -92.33% vs AMZN's -94.40%.

Which has better risk-adjusted returns?

AMZN currently has the higher Sharpe Ratio (0.32 vs 0.26), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.