Synlogic, Inc. (SYBX)

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Synlogic, Inc. (SYBX) is down 37.5% since the beginning of the year. At $1 per share, SYBX is trading 64.3% below its 52-week high of $2. Investors who bought $1,000 worth of SYBX shares 5 years ago would now be looking at an investment worth $13.

Synlogic, Inc. (SYBX) has returned -37.50% so far this year and -41.28% over the past 12 months. Over the last ten years, SYBX has returned -47.95% per year, falling short of the S&P 500 Index benchmark, which averaged 13.75% annually.

Based on dividend-adjusted daily data since Oct 1, 2015, SYBX's average daily return is -0.12%, while the average monthly return is -3.01%.

Historically, 41% of months were positive and 59% were negative. The best month was Jan 2021 with a return of +71.8%, while the worst month was Sep 2023 at -61.8%. The longest winning streak lasted 4 consecutive months, and the longest losing streak was 7 months.

On a daily basis, SYBX closed higher 44% of trading days. The best single day was Mar 17, 2020 with a return of +63.8%, while the worst single day was Jan 20, 2026 at -50.0%.

Synlogic, Inc. has an annualized alpha of -36.47%, beta of 1.05, and R2 of 0.05 versus S&P 500 Index. Calculated based on daily prices since October 02, 2015.

• This stock participated in 216.92% of S&P 500 Index downside but only -34.88% of its upside - more exposed to losses than it benefited from rallies.
• R2 of 0.05 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

SYBX ranks 21 for risk / return — below 21% of stocks on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.

The table below present risk-adjusted performance metrics for Synlogic, Inc. (SYBX) and compare them to S&P 500 Index.

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Synlogic, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Synlogic, Inc. was 99.94%, occurring on Jan 20, 2026. The portfolio has not yet recovered.

The current Synlogic, Inc. drawdown is 99.93%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Synlogic, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Synlogic, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.