Pyxis Oncology, Inc. (PYXS)

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The chart shows the growth of an initial investment of $10,000 in Pyxis Oncology, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.

Pyxis Oncology, Inc. (PYXS) has returned 26.96% so far this year and 48.99% over the past 12 months.

Based on dividend-adjusted daily data since Oct 8, 2021, PYXS's average daily return is +0.01%, while the average monthly return is +1.10%. At this rate, your investment would double in approximately 5.3 years.

Historically, 43% of months were positive and 57% were negative. The best month was Jan 2024 with a return of +111.7%, while the worst month was Dec 2025 at -77.8%. The longest winning streak lasted 5 consecutive months, and the longest losing streak was 6 months.

On a daily basis, PYXS closed higher 45% of trading days. The best single day was Mar 28, 2023 with a return of +42.6%, while the worst single day was Dec 18, 2025 at -48.7%.

Pyxis Oncology, Inc. has an annualized alpha of -8.50%, beta of 1.11, and R² of 0.04 versus S&P 500 Index. Calculated based on daily prices since October 11, 2021.

• This stock participated in 236.62% of S&P 500 Index downside but only 131.36% of its upside — more exposed to losses than it benefited from rallies.
• R² of 0.04 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

PYXS ranks 58 for risk / return — on par with similar stocks. You're getting a typical balance of risk and reward. Not a standout, but not a red flag either — a reasonable choice if other factors align with your goals.

The table below present risk-adjusted performance metrics for Pyxis Oncology, Inc. (PYXS) and compare them to a chosen benchmark (S&P 500 Index).

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Pyxis Oncology, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Pyxis Oncology, Inc. was 93.57%, occurring on Apr 8, 2025. The portfolio has not yet recovered.

The current Pyxis Oncology, Inc. drawdown is 89.30%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Pyxis Oncology, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Pyxis Oncology, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.