OnKure Therapeutics, Inc (OKUR)

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OnKure Therapeutics, Inc (OKUR) is up 45.5% since the beginning of the year. At $4 per share, OKUR is trading 21.6% below its 52-week high of $5.

OnKure Therapeutics, Inc (OKUR) has returned 45.52% so far this year and 59.25% over the past 12 months.

Based on dividend-adjusted daily data since Oct 7, 2024, OKUR's average daily return is -0.25%, while the average monthly return is -4.30%.

Historically, 38% of months were positive and 62% were negative. The best month was Mar 2026 with a return of +52.8%, while the worst month was Dec 2024 at -44.2%. The longest winning streak lasted 3 consecutive months, and the longest losing streak was 7 months.

On a daily basis, OKUR closed higher 40% of trading days. The best single day was Aug 13, 2025 with a return of +20.0%, while the worst single day was Apr 4, 2025 at -19.5%.

OnKure Therapeutics, Inc has an annualized alpha of -56.43%, beta of 1.03, and R2 of 0.05 versus S&P 500 Index. Calculated based on daily prices since October 08, 2024.

• This stock participated in 336.24% of S&P 500 Index downside but only -61.75% of its upside - more exposed to losses than it benefited from rallies.
• R2 of 0.05 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

OKUR ranks 66 for risk / return — better than 66% of stocks on our site. You're getting solid returns for the risk taken. A good sign, especially for investors who want growth without excessive volatility.

The table below present risk-adjusted performance metrics for OnKure Therapeutics, Inc (OKUR) and compare them to S&P 500 Index.

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the OnKure Therapeutics, Inc. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the OnKure Therapeutics, Inc was 90.47%, occurring on May 14, 2025. The portfolio has not yet recovered.

The current OnKure Therapeutics, Inc drawdown is 78.03%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of OnKure Therapeutics, Inc over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how OnKure Therapeutics, Inc is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.