- ISIN
- US55083R1041
- CUSIP
- 55083R104
- Sector
- Healthcare
- Industry
- Biotechnology
- IPO Date
- Jun 17, 2021
Highlights
- Market Cap
- $261.86M
- Enterprise Value
- $210.57M
- EPS (TTM)
- -$13.68
- Total Revenue (TTM)
- $31.00K
- Gross Profit (TTM)
- -$11.51M
- EBITDA (TTM)
- -$140.21M
- Year Range
- $8.46 - $45.00
- Target Price
- $46.00
- ROA (TTM)
- -70.28%
- ROE (TTM)
- -90.04%
Share Price Chart
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Performance
LYEL Performance Chart
Lyell Immunopharma, Inc. (LYEL) is down 61.1% since the beginning of the year. At $12 per share, LYEL is trading 73.4% below its 52-week high of $45. Investors who bought $1,000 worth of LYEL shares 5 years ago would now be looking at an investment worth $36.
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Returns By Period
Lyell Immunopharma, Inc. (LYEL) has returned -61.11% so far this year and 37.74% over the past 12 months.
Lyell Immunopharma, Inc.
- 1D
- -6.04%
- 1M
- -31.44%
- YTD
- -61.11%
- 6M
- -67.97%
- 1Y
- 37.74%
- 3Y*
- -43.17%
- 5Y*
- -48.52%
- 10Y*
- —
Benchmark (S&P 500 Index)
- 1D
- -0.37%
- 1M
- -0.01%
- YTD
- 9.16%
- 6M
- 8.64%
- 1Y
- 25.22%
- 3Y*
- 19.78%
- 5Y*
- 11.99%
- 10Y*
- 13.88%
LYEL Monthly Returns History
Based on dividend-adjusted daily data since Jun 17, 2021, LYEL's average daily return is -0.10%, while the average monthly return is -2.72%.
Historically, 36% of months were positive and 64% were negative. The best month was Feb 2024 with a return of +59.6%, while the worst month was Jun 2024 at -47.7%. The longest winning streak lasted 4 consecutive months, and the longest losing streak was 6 months.
On a daily basis, LYEL closed higher 46% of trading days. The best single day was Jun 4, 2025 with a return of +68.6%, while the worst single day was Jun 26, 2024 at -36.0%.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | -22.03% | 0.00% | -16.42% | -1.65% | -12.16% | -30.93% | -61.11% | ||||||
| 2025 | -7.77% | 20.41% | -24.31% | -11.67% | -8.10% | 1.21% | 33.60% | -6.18% | 46.57% | 2.59% | 44.06% | 28.25% | 140.47% |
| 2024 | -5.67% | 59.56% | -23.63% | -2.69% | 27.65% | -47.65% | 11.03% | -9.94% | -4.83% | -30.41% | -1.59% | -32.28% | -67.01% |
| 2023 | -5.76% | -34.25% | 9.77% | -13.98% | 57.14% | -0.31% | -9.12% | -17.30% | -38.49% | 12.59% | 4.53% | 12.14% | -44.09% |
| 2022 | -26.61% | 27.46% | -30.25% | 1.58% | -19.30% | 57.49% | -14.57% | 20.29% | 9.40% | -19.78% | -28.40% | -17.58% | -55.17% |
| 2021 | -13.39% | -10.71% | 8.90% | -6.27% | -5.81% | -31.49% | -18.95% | -58.72% |
Benchmark Metrics
Lyell Immunopharma, Inc. has an annualized alpha of -36.79%, beta of 1.59, and R2 of 0.08 versus S&P 500 Index. Calculated based on daily prices since June 17, 2021.
- This stock participated in 187.51% of S&P 500 Index downside but only -54.92% of its upside - more exposed to losses than it benefited from rallies.
- R2 of 0.08 means this stock moves largely independently of S&P 500 Index - capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.
- Alpha
- -36.79%
- Beta
- 1.59
- R²
- 0.08
- Upside Capture
- -54.92%
- Downside Capture
- 187.51%
Return for Risk
Risk / Return Rank
LYEL ranks 58 for risk / return — on par with similar stocks. You're getting a typical balance of risk and reward. Not a standout, but not a red flag either — a reasonable choice if other factors align with your goals.
Return / Risk — by metrics
The table below present risk-adjusted performance metrics for Lyell Immunopharma, Inc. (LYEL) and compare them to S&P 500 Index.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| LYEL | Benchmark | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | -1.56 | ||
| Sortino ratioReturn per unit of downside risk | -1.53 | ||
| Omega ratioGain probability vs. loss probability | 1.15 | 1.37 | -0.22 |
| Calmar ratioReturn relative to maximum drawdown | 0.55 | 2.78 | -2.23 |
| Martin ratioReturn relative to average drawdown | 1.16 | 12.44 | -11.28 |
Dividends
Dividend History
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the Lyell Immunopharma, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Lyell Immunopharma, Inc. was 97.92%, occurring on May 14, 2025. The portfolio has not yet recovered.
The current Lyell Immunopharma, Inc. drawdown is 96.81%.
Related event | Drawdown | Fall | Recovery | Underwater |
|---|---|---|---|---|
2025 selloff2025 | -97.92%May 2025 | 3y 11mo | — | 5y 7dJun 2021 - now |
Drawdown Indicators
| LYEL | Benchmark | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -97.92% | -56.78% | -41.14% |
Max Drawdown (1Y)Largest decline over 1 year | -68.99% | -9.10% | -59.89% |
Max Drawdown (3Y)Largest decline over 3 years | -88.36% | -18.90% | -69.46% |
Max Drawdown (5Y)Largest decline over 5 years | -97.83% | -25.43% | -72.40% |
Max Drawdown (10Y)Largest decline over 10 years | — | -33.92% | — |
Current DrawdownCurrent decline from peak | -96.81% | -1.80% | -95.01% |
Average DrawdownAverage peak-to-trough decline | -80.46% | -10.71% | -69.75% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 32.58% | 2.03% | +30.55% |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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Financials
Financial Performance
The chart below illustrates the trends in the financial health of Lyell Immunopharma, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.
Valuation
The Valuation section provides an overview of how Lyell Immunopharma, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.
PS Ratio
This chart shows the Price-to-Sales (P/S) ratio for LYEL relative to other companies in the Biotechnology industry. Currently, LYEL has a P/S ratio of 6,953.2. This P/S ratio is high relative to other companies in the industry. It could mean the stock is overvalued, or that investors expect strong future growth and profitability.
PB Ratio
The chart illustrates the Price-to-Book (P/B) ratio for LYEL in comparison with other companies in the Biotechnology industry. Currently, LYEL has a P/B value of 1.0. This P/B ratio is low compared to industry peers. It might indicate the stock is undervalued or that the company’s assets are not expected to generate strong returns.
Income Statement
| TTM | |
|---|---|
Revenue | — |
Total Revenue | — |
Cost Of Revenue | — |
Gross Profit | — |
Operating Expenses | — |
Selling, General & Admin Expenses | — |
R&D Expenses | — |
Depreciation And Amortization | — |
Total Operating Expenses | — |
Income | — |
Income Before Tax | — |
Operating Income | — |
EBITDA | — |
EBIT | — |
Earnings From Continuing Operations | — |
Net Income | — |
Income Tax Expense | — |
Other Non-Operating Income (Expenses) | — |
Extraordinary Items | — |
Discontinued Operations | — |
Effect Of Accounting Charges | — |
Non Recurring | — |
Minority Interest | — |
Other Items | — |
Interest Income | — |
Interest Expense | — |
Net Interest Income | — |
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