CalciMedica Inc. Common Stock (CALC)

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The chart shows the growth of an initial investment of $10,000 in CalciMedica Inc. Common Stock, comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.

CalciMedica Inc. Common Stock (CALC) has returned -91.81% so far this year and -71.73% over the past 12 months.

Based on dividend-adjusted daily data since Sep 25, 2020, CALC's average daily return is -0.17%, while the average monthly return is -1.84%.

Historically, 34% of months were positive and 66% were negative. The best month was Jan 2024 with a return of +160.1%, while the worst month was Jan 2026 at -86.3%. The longest winning streak lasted 4 consecutive months, and the longest losing streak was 9 months.

On a daily basis, CALC closed higher 44% of trading days. The best single day was Apr 14, 2023 with a return of +58.6%, while the worst single day was Jan 28, 2026 at -75.6%.

CalciMedica Inc. Common Stock has an annualized alpha of -38.33%, beta of 0.48, and R² of 0.01 versus S&P 500 Index. Calculated based on daily prices since September 28, 2020.

• This stock participated in 175.41% of S&P 500 Index downside but only -121.57% of its upside — more exposed to losses than it benefited from rallies.
• Beta of 0.48 may look defensive, but with R² of 0.01 this stock is largely uncorrelated with S&P 500 Index — low beta reflects independence, not downside protection. See the Volatility section for a true picture of this stock's risk.
• R² of 0.01 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

CALC ranks 18 for risk / return — in the bottom 18% of stocks on our site. This means you're taking on significantly more risk than the returns justify. Consider whether the potential upside is worth the volatility, or explore alternatives with better risk / return profiles.

The table below present risk-adjusted performance metrics for CalciMedica Inc. Common Stock (CALC) and compare them to a chosen benchmark (S&P 500 Index).

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the CalciMedica Inc. Common Stock. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the CalciMedica Inc. Common Stock was 99.90%, occurring on Mar 2, 2026. The portfolio has not yet recovered.

The current CalciMedica Inc. Common Stock drawdown is 99.89%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of CalciMedica Inc. Common Stock over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how CalciMedica Inc. Common Stock is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.