XSHC.L vs. GNOM.L

Last updated Jul 16, 2026

XSHC.L (Xtrackers MSCI USA Health Care UCITS ETF 1D) and GNOM.L (Global X Genomics & Biotechnology UCITS ETF) are both Health & Biotech Equities funds - XSHC.L tracks the MSCI World/Health Care NR USD while GNOM.L tracks the Global X Genomics & Biotechnology UCITS ETF. Both are passively managed. Over the past 3 years, XSHC.L returned 6.92%/yr vs 3.46%/yr for GNOM.L. At a 0.43 correlation, their price movements are largely independent. XSHC.L charges 0.12%/yr vs 0.50%/yr for GNOM.L.

Performance

XSHC.L vs. GNOM.L - Performance Comparison

The chart below illustrates the hypothetical performance of a £10,000 investment in Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L) and Global X Genomics & Biotechnology UCITS ETF (GNOM.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

XSHC.L is traded in GBp, while GNOM.L is traded in USD. To make them comparable, the GNOM.L values have been converted to GBp using the latest available exchange rates.

Returns By Period

In the year-to-date period, XSHC.L achieves a 2.07% return, which is significantly lower than GNOM.L's 21.80% return.

XSHC.L

• 1D: -0.30%
• 1M: 3.82%
• 6M: 1.23%
• YTD: 2.07%
• 1Y: 19.69%
• 3Y*: 6.92%
• 5Y*: 5.82%
• 10Y*: —

GNOM.L

• 1D: 0.00%
• 1M: 10.90%
• 6M: 15.21%
• YTD: 21.80%
• 1Y: 61.34%
• 3Y*: 3.46%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

XSHC.L vs. GNOM.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
XSHC.L Xtrackers MSCI USA Health Care UCITS ETF 1D	2.07%	6.84%	4.08%	-3.58%	8.14%	6.70%
GNOM.L Global X Genomics & Biotechnology UCITS ETF	21.80%	10.80%	-16.55%	-10.48%	-29.74%	-8.05%

Correlation

The correlation between XSHC.L and GNOM.L is 0.46, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.46
Correlation (3Y) Calculated over the trailing 3-year period	0.42
Correlation (All Time) Calculated using the full available price history since Nov 2, 2021	0.43

Return for Risk

XSHC.L vs. GNOM.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XSHC.L

XSHC.L Risk / Return Rank: 40
XSHC.L Sharpe Ratio Rank: 44
XSHC.L Sortino Ratio Rank: 47
XSHC.L Omega Ratio Rank: 39
XSHC.L Calmar Ratio Rank: 38
XSHC.L Martin Ratio Rank: 32

GNOM.L

GNOM.L Risk / Return Rank: 77
GNOM.L Sharpe Ratio Rank: 83
GNOM.L Sortino Ratio Rank: 83
GNOM.L Omega Ratio Rank: 73
GNOM.L Calmar Ratio Rank: 80
GNOM.L Martin Ratio Rank: 64

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XSHC.L vs. GNOM.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L) and Global X Genomics & Biotechnology UCITS ETF (GNOM.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XSHC.L	GNOM.L	Difference
Sharpe ratio: Return per unit of total volatility	1.30	2.13	-0.84
Sortino ratio: Return per unit of downside risk	1.98	2.94	-0.96
Omega ratio: Gain probability vs. loss probability	1.22	1.34	-0.12
Calmar ratio: Return relative to maximum drawdown	1.60	3.66	-2.06
Martin ratio: Return relative to average drawdown	3.91	9.16	-5.25

XSHC.L vs. GNOM.L - Sharpe Ratio Comparison

The current XSHC.L Sharpe Ratio is 1.30, which is lower than the GNOM.L Sharpe Ratio of 2.13. The chart below compares the historical Sharpe Ratios of XSHC.L and GNOM.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XSHC.L vs. GNOM.L - Drawdown Comparison

The maximum XSHC.L drawdown since its inception was -19.16%, smaller than the maximum GNOM.L drawdown of -67.55%. Use the drawdown chart below to compare losses from any high point for XSHC.L and GNOM.L.

Drawdown Indicators

	XSHC.L	GNOM.L	Difference
Max Drawdown Largest peak-to-trough decline	-19.16%	-67.55%	+48.39%
Max Drawdown (1Y) Largest decline over 1 year	-12.22%	-16.99%	+4.77%
Max Drawdown (3Y) Largest decline over 3 years	-19.16%	-45.06%	+25.90%
Max Drawdown (5Y) Largest decline over 5 years	-19.16%	—	—
Current Drawdown Current decline from peak	-4.30%	-36.84%	+32.54%
Average Drawdown Average peak-to-trough decline	-4.77%	-43.90%	+39.13%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.02%	6.80%	-1.78%

Volatility

XSHC.L vs. GNOM.L - Volatility Comparison

The current volatility for Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L) is 5.34%, while Global X Genomics & Biotechnology UCITS ETF (GNOM.L) has a volatility of 8.45%. This indicates that XSHC.L experiences smaller price fluctuations and is considered to be less risky than GNOM.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XSHC.L	GNOM.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	5.34%	8.45%	-3.11%
Volatility (6M) Calculated over the trailing 6-month period	10.99%	21.47%	-10.48%
Volatility (1Y) Calculated over the trailing 1-year period	15.18%	29.21%	-14.03%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	14.38%	32.06%	-17.68%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	15.76%	32.06%	-16.30%

XSHC.L vs. GNOM.L - Expense Ratio Comparison

XSHC.L has a 0.12% expense ratio, which is lower than GNOM.L's 0.50% expense ratio.

Dividends

XSHC.L vs. GNOM.L - Dividend Comparison

XSHC.L's dividend yield for the trailing twelve months is around 1.23%, while GNOM.L has not paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019
GNOM.L Global X Genomics & Biotechnology UCITS ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XSHC.L Xtrackers MSCI USA Health Care UCITS ETF 1D	1.23%	1.25%	1.24%	1.23%	1.55%	0.85%	1.12%	0.98%

Frequently Asked Questions

Can I hold both XSHC.L and GNOM.L in my portfolio?

XSHC.L and GNOM.L have a correlation of 0.46, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, XSHC.L or GNOM.L?

On fees, XSHC.L is cheaper at 0.12% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, XSHC.L or GNOM.L?

XSHC.L is cheaper with a 0.12% expense ratio, compared with 0.50% for GNOM.L.

What is the main difference between XSHC.L and GNOM.L?

XSHC.L tracks MSCI World/Health Care NR USD, while GNOM.L tracks Global X Genomics & Biotechnology UCITS ETF. They also come from different issuers: Xtrackers and Global X. Their fees differ too: 0.12% for XSHC.L and 0.50% for GNOM.L.