XBI vs. VXUS

Last updated Jun 16, 2026

XBI (SPDR S&P Biotech ETF) and VXUS (Vanguard Total International Stock ETF) are both exchange-traded funds - XBI is a Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index, while VXUS is a Global Equities fund tracking the FTSE Global All Cap ex US Index. Both are passively managed. Over the past 10 years, XBI returned 9.98%/yr vs 10.23%/yr for VXUS. A 0.51 correlation means they provide meaningful diversification when combined. XBI charges 0.35%/yr vs 0.05%/yr for VXUS.

Performance

XBI vs. VXUS - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and Vanguard Total International Stock ETF (VXUS). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, XBI achieves a 11.87% return, which is significantly lower than VXUS's 15.42% return. Both investments have delivered pretty close results over the past 10 years, with XBI having a 9.98% annualized return and VXUS not far ahead at 10.23%.

XBI

• 1D: 1.95%
• 1M: 4.37%
• YTD: 11.87%
• 6M: 11.41%
• 1Y: 63.76%
• 3Y*: 16.08%
• 5Y*: 0.52%
• 10Y*: 9.98%

VXUS

• 1D: 1.52%
• 1M: 4.66%
• YTD: 15.42%
• 6M: 16.87%
• 1Y: 32.10%
• 3Y*: 18.53%
• 5Y*: 8.83%
• 10Y*: 10.23%

*Multi-year figures are annualized to reflect compound growth (CAGR)

XBI vs. VXUS - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XBI SPDR S&P Biotech ETF	11.87%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%
VXUS Vanguard Total International Stock ETF	15.42%	32.35%	5.08%	15.86%	-16.08%	8.98%	10.66%	21.75%	-14.43%	27.46%

Correlation

The correlation between XBI and VXUS is 0.51, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.51
Correlation (3Y) Calculated over the trailing 3-year period	0.52
Correlation (5Y) Calculated over the trailing 5-year period	0.53
Correlation (10Y) Calculated over the trailing 10-year period	0.52
Correlation (All Time) Calculated using the full available price history since Jan 28, 2011	0.51

The correlation between XBI and VXUS has been stable across timeframes, ranging from 0.51 to 0.53 - a consistent structural relationship.

XBI vs. VXUS - Sectors Allocation Comparison

Sectors	XBI	VXUS
Healthcare	99.7%	7.1%
Financial Services	0.3%	22.3%
Basic Materials	0.2%	7.6%
Communication Services	-	4.4%
Consumer Cyclical	-	8.4%
Consumer Defensive	-	5.0%
Energy	-	5.2%
Industrials	-	16.1%
Real Estate	-	2.6%
Technology	-	18.1%
Utilities	-	3.2%

Return for Risk

XBI vs. VXUS — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 86
XBI Sharpe Ratio Rank: 85
XBI Sortino Ratio Rank: 83
XBI Omega Ratio Rank: 74
XBI Calmar Ratio Rank: 94
XBI Martin Ratio Rank: 91

VXUS

VXUS Risk / Return Rank: 67
VXUS Sharpe Ratio Rank: 69
VXUS Sortino Ratio Rank: 67
VXUS Omega Ratio Rank: 70
VXUS Calmar Ratio Rank: 63
VXUS Martin Ratio Rank: 67

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. VXUS - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and Vanguard Total International Stock ETF (VXUS). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	XBI	VXUS	Difference
Sharpe ratio: Return per unit of total volatility	2.45	2.01	+0.45
Sortino ratio: Return per unit of downside risk	3.29	2.73	+0.56
Omega ratio: Gain probability vs. loss probability	1.39	1.37	+0.02
Calmar ratio: Return relative to maximum drawdown	6.59	2.86	+3.73
Martin ratio: Return relative to average drawdown	19.47	11.00	+8.47

XBI vs. VXUS - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 2.45, which is comparable to the VXUS Sharpe Ratio of 2.01. The chart below compares the historical Sharpe Ratios of XBI and VXUS, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

XBI vs. VXUS - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, which is greater than VXUS's maximum drawdown of -35.97%. Use the drawdown chart below to compare losses from any high point for XBI and VXUS.

Drawdown Indicators

	XBI	VXUS	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-35.97%	-27.92%
Max Drawdown (1Y) Largest decline over 1 year	-9.72%	-11.27%	+1.55%
Max Drawdown (3Y) Largest decline over 3 years	-32.99%	-13.58%	-19.41%
Max Drawdown (5Y) Largest decline over 5 years	-54.71%	-29.44%	-25.27%
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	-35.97%	-27.92%
Current Drawdown Current decline from peak	-21.16%	0.00%	-21.16%
Average Drawdown Average peak-to-trough decline	-20.93%	-8.20%	-12.73%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.29%	2.93%	+0.36%

Volatility

XBI vs. VXUS - Volatility Comparison

SPDR S&P Biotech ETF (XBI) has a higher volatility of 10.55% compared to Vanguard Total International Stock ETF (VXUS) at 6.87%. This indicates that XBI's price experiences larger fluctuations and is considered to be riskier than VXUS based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	VXUS	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.55%	6.87%	+3.68%
Volatility (6M) Calculated over the trailing 6-month period	20.83%	14.09%	+6.74%
Volatility (1Y) Calculated over the trailing 1-year period	26.18%	16.11%	+10.07%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.22%	16.23%	+15.99%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.03%	17.21%	+14.82%

XBI vs. VXUS - Expense Ratio Comparison

XBI has a 0.35% expense ratio, which is higher than VXUS's 0.05% expense ratio.

Dividends

XBI vs. VXUS - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.32%, less than VXUS's 2.63% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
VXUS Vanguard Total International Stock ETF	2.63%	3.18%	3.37%	3.24%	3.09%	3.10%	2.14%	3.06%	3.18%	2.73%	2.93%	2.83%
XBI SPDR S&P Biotech ETF	0.32%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both XBI and VXUS in my portfolio?

XBI and VXUS have a correlation of 0.51, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, XBI or VXUS?

XBI has higher volatility (10.55%) compared to VXUS (6.87%). In terms of maximum drawdown, XBI dropped -63.89% vs VXUS's -35.97%.

Which ETF is better, XBI or VXUS?

On 10-year performance, VXUS leads with 10.23% vs 9.98% for XBI. On fees, VXUS is cheaper at 0.05% per year. On volatility, VXUS has been the lower-risk option at 6.87%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, XBI or VXUS?

Over the 10-year period, VXUS has performed better with a 10.23% return vs 9.98%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, XBI or VXUS?

VXUS is cheaper with a 0.05% expense ratio, compared with 0.35% for XBI.

Which ETF pays a higher dividend yield, XBI or VXUS?

VXUS has the higher dividend yield at 2.63%, compared with 0.32% for XBI.

What is the main difference between XBI and VXUS?

XBI is categorized as Health & Biotech Equities, while VXUS is Global Equities. XBI tracks S&P Biotechnology Select Industry Index, while VXUS tracks FTSE Global All Cap ex US Index. They also come from different issuers: State Street and Vanguard. Their fees differ too: 0.35% for XBI and 0.05% for VXUS.

Which has better risk-adjusted returns?

XBI currently has the higher Sharpe Ratio (2.45 vs 2.01), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.