WRNA.DE vs. LYPE.DE

Last updated Jun 5, 2026

WRNA.DE (WisdomTree BioRevolution UCITS ETF USD Acc) and LYPE.DE (Amundi MSCI World Health Care UCITS ETF EUR Acc) are both Health & Biotech Equities funds - WRNA.DE tracks the WisdomTree BioRevolution ESG Screened while LYPE.DE tracks the MSCI World Health Care. Both are passively managed. Over the past 3 years, WRNA.DE returned 0.92%/yr vs 2.46%/yr for LYPE.DE. A 0.58 correlation means they provide meaningful diversification when combined. WRNA.DE charges 0.45%/yr vs 0.30%/yr for LYPE.DE.

Performance

WRNA.DE vs. LYPE.DE - Performance Comparison

The chart below illustrates the hypothetical performance of a €10,000 investment in WisdomTree BioRevolution UCITS ETF USD Acc (WRNA.DE) and Amundi MSCI World Health Care UCITS ETF EUR Acc (LYPE.DE). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, WRNA.DE achieves a 10.48% return, which is significantly higher than LYPE.DE's -2.00% return.

WRNA.DE

• 1D: 4.08%
• 1M: 4.18%
• YTD: 10.48%
• 6M: 10.41%
• 1Y: 48.70%
• 3Y*: 0.92%
• 5Y*: —
• 10Y*: —

LYPE.DE

• 1D: 2.79%
• 1M: 3.83%
• YTD: -2.00%
• 6M: -1.54%
• 1Y: 9.49%
• 3Y*: 2.46%
• 5Y*: 5.27%
• 10Y*: 7.45%

*Multi-year figures are annualized to reflect compound growth (CAGR)

WRNA.DE vs. LYPE.DE - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
WRNA.DE WisdomTree BioRevolution UCITS ETF USD Acc	10.48%	9.13%	-10.92%	-3.37%	-22.01%	-0.98%
LYPE.DE Amundi MSCI World Health Care UCITS ETF EUR Acc	-2.00%	2.17%	7.03%	-0.27%	-0.17%	4.14%

Correlation

The correlation between WRNA.DE and LYPE.DE is 0.56, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.56
Correlation (3Y) Calculated over the trailing 3-year period	0.51
Correlation (All Time) Calculated using the full available price history since Dec 10, 2021	0.58

The correlation between WRNA.DE and LYPE.DE has been stable across timeframes, ranging from 0.51 to 0.58 - a consistent structural relationship.

Return for Risk

WRNA.DE vs. LYPE.DE — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

WRNA.DE

WRNA.DE Risk / Return Rank: 56
WRNA.DE Sharpe Ratio Rank: 52
WRNA.DE Sortino Ratio Rank: 52
WRNA.DE Omega Ratio Rank: 48
WRNA.DE Calmar Ratio Rank: 73
WRNA.DE Martin Ratio Rank: 56

LYPE.DE

LYPE.DE Risk / Return Rank: 21
LYPE.DE Sharpe Ratio Rank: 21
LYPE.DE Sortino Ratio Rank: 22
LYPE.DE Omega Ratio Rank: 20
LYPE.DE Calmar Ratio Rank: 21
LYPE.DE Martin Ratio Rank: 20

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

WRNA.DE vs. LYPE.DE - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WisdomTree BioRevolution UCITS ETF USD Acc (WRNA.DE) and Amundi MSCI World Health Care UCITS ETF EUR Acc (LYPE.DE). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	WRNA.DE	LYPE.DE	Difference
Sharpe ratio: Return per unit of total volatility	1.75	0.68	+1.07
Sortino ratio: Return per unit of downside risk	2.46	1.13	+1.34
Omega ratio: Gain probability vs. loss probability	1.30	1.13	+0.17
Calmar ratio: Return relative to maximum drawdown	3.61	0.93	+2.69
Martin ratio: Return relative to average drawdown	9.63	2.27	+7.36
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

WRNA.DE vs. LYPE.DE - Sharpe Ratio Comparison

The current WRNA.DE Sharpe Ratio is 1.75, which is higher than the LYPE.DE Sharpe Ratio of 0.68. The chart below compares the historical Sharpe Ratios of WRNA.DE and LYPE.DE, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	WRNA.DE	LYPE.DE	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.75	0.68	+1.07
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.39	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.51	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.20	0.76	-0.96

Drawdowns

WRNA.DE vs. LYPE.DE - Drawdown Comparison

The maximum WRNA.DE drawdown since its inception was -52.35%, which is greater than LYPE.DE's maximum drawdown of -25.95%. Use the drawdown chart below to compare losses from any high point for WRNA.DE and LYPE.DE.

Drawdown Indicators

	WRNA.DE	LYPE.DE	Difference
Max Drawdown Largest peak-to-trough decline	-52.35%	-25.95%	-26.40%
Max Drawdown (1Y) Largest decline over 1 year	-13.42%	-10.21%	-3.21%
Max Drawdown (3Y) Largest decline over 3 years	-40.06%	-21.30%	-18.76%
Max Drawdown (5Y) Largest decline over 5 years	—	-21.30%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-25.95%	—
Current Drawdown Current decline from peak	-20.73%	-8.75%	-11.98%
Average Drawdown Average peak-to-trough decline	-27.26%	-5.06%	-22.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.04%	4.18%	+0.86%

Volatility

WRNA.DE vs. LYPE.DE - Volatility Comparison

WisdomTree BioRevolution UCITS ETF USD Acc (WRNA.DE) has a higher volatility of 6.73% compared to Amundi MSCI World Health Care UCITS ETF EUR Acc (LYPE.DE) at 4.96%. This indicates that WRNA.DE's price experiences larger fluctuations and is considered to be riskier than LYPE.DE based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	WRNA.DE	LYPE.DE	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.73%	4.96%	+1.77%
Volatility (6M) Calculated over the trailing 6-month period	17.21%	9.76%	+7.45%
Volatility (1Y) Calculated over the trailing 1-year period	27.70%	13.82%	+13.88%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	24.22%	13.41%	+10.81%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	24.22%	14.64%	+9.58%

WRNA.DE vs. LYPE.DE - Expense Ratio Comparison

WRNA.DE has a 0.45% expense ratio, which is higher than LYPE.DE's 0.30% expense ratio.

Dividends

WRNA.DE vs. LYPE.DE - Dividend Comparison

Neither WRNA.DE nor LYPE.DE has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both WRNA.DE and LYPE.DE in my portfolio?

WRNA.DE and LYPE.DE have a correlation of 0.56, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, WRNA.DE or LYPE.DE?

On fees, LYPE.DE is cheaper at 0.30% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, WRNA.DE or LYPE.DE?

LYPE.DE is cheaper with a 0.30% expense ratio, compared with 0.45% for WRNA.DE.

What is the main difference between WRNA.DE and LYPE.DE?

WRNA.DE tracks WisdomTree BioRevolution ESG Screened, while LYPE.DE tracks MSCI World Health Care. They also come from different issuers: WisdomTree and Amundi. Their fees differ too: 0.45% for WRNA.DE and 0.30% for LYPE.DE.