WBIO.L vs. IUHC.L

Last updated Jun 5, 2026

WBIO.L (WisdomTree BioRevolution UCITS ETF USD Acc) and IUHC.L (iShares S&P 500 Health Care Sector UCITS ETF USD (Acc)) are both Health & Biotech Equities funds - WBIO.L tracks the NASDAQ Biotechnology TR USD while IUHC.L tracks the S&P 500 Capped 35/20 Health Care Index. Both are passively managed. Over the past 3 years, WBIO.L returned 1.10%/yr vs 3.91%/yr for IUHC.L. A 0.50 correlation means they provide meaningful diversification when combined. WBIO.L charges 0.45%/yr vs 0.15%/yr for IUHC.L.

Performance

WBIO.L vs. IUHC.L - Performance Comparison

The chart below illustrates the hypothetical performance of a £10,000 investment in WisdomTree BioRevolution UCITS ETF USD Acc (WBIO.L) and iShares S&P 500 Health Care Sector UCITS ETF USD (Acc) (IUHC.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

WBIO.L is traded in GBp, while IUHC.L is traded in USD. To make them comparable, the IUHC.L values have been converted to GBp using the latest available exchange rates.

Returns By Period

In the year-to-date period, WBIO.L achieves a 10.42% return, which is significantly higher than IUHC.L's -1.69% return.

WBIO.L

• 1D: 4.36%
• 1M: 3.58%
• YTD: 10.42%
• 6M: 10.85%
• 1Y: 51.43%
• 3Y*: 1.10%
• 5Y*: —
• 10Y*: —

IUHC.L

• 1D: 3.00%
• 1M: 5.68%
• YTD: -1.69%
• 6M: -1.14%
• 1Y: 16.15%
• 3Y*: 3.91%
• 5Y*: 6.89%
• 10Y*: 10.02%

*Multi-year figures are annualized to reflect compound growth (CAGR)

WBIO.L vs. IUHC.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
WBIO.L WisdomTree BioRevolution UCITS ETF USD Acc	10.42%	13.58%	-14.08%	-5.86%	-18.74%	-1.39%
IUHC.L iShares S&P 500 Health Care Sector UCITS ETF USD (Acc)	-1.72%	6.50%	3.95%	-3.36%	8.95%	3.07%

Correlation

The correlation between WBIO.L and IUHC.L is 0.51, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.51
Correlation (3Y) Calculated over the trailing 3-year period	0.46
Correlation (All Time) Calculated using the full available price history since Dec 10, 2021	0.50

The correlation between WBIO.L and IUHC.L has been stable across timeframes, ranging from 0.46 to 0.51 - a consistent structural relationship.

WBIO.L vs. IUHC.L - Sectors Allocation Comparison

Sectors	WBIO.L	IUHC.L
Healthcare	87.3%	100.0%
Basic Materials	7.6%	-
Consumer Defensive	5.1%	-
Communication Services	-	-
Consumer Cyclical	-	-
Energy	-	-
Financial Services	-	-
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

WBIO.L vs. IUHC.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

WBIO.L

WBIO.L Risk / Return Rank: 61
WBIO.L Sharpe Ratio Rank: 57
WBIO.L Sortino Ratio Rank: 55
WBIO.L Omega Ratio Rank: 51
WBIO.L Calmar Ratio Rank: 83
WBIO.L Martin Ratio Rank: 59

IUHC.L

IUHC.L Risk / Return Rank: 29
IUHC.L Sharpe Ratio Rank: 29
IUHC.L Sortino Ratio Rank: 30
IUHC.L Omega Ratio Rank: 27
IUHC.L Calmar Ratio Rank: 30
IUHC.L Martin Ratio Rank: 27

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

WBIO.L vs. IUHC.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for WisdomTree BioRevolution UCITS ETF USD Acc (WBIO.L) and iShares S&P 500 Health Care Sector UCITS ETF USD (Acc) (IUHC.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	WBIO.L	IUHC.L	Difference
Sharpe ratio: Return per unit of total volatility	1.91	1.04	+0.87
Sortino ratio: Return per unit of downside risk	2.63	1.58	+1.05
Omega ratio: Gain probability vs. loss probability	1.31	1.18	+0.13
Calmar ratio: Return relative to maximum drawdown	4.40	1.38	+3.03
Martin ratio: Return relative to average drawdown	10.38	3.47	+6.91
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

WBIO.L vs. IUHC.L - Sharpe Ratio Comparison

The current WBIO.L Sharpe Ratio is 1.91, which is higher than the IUHC.L Sharpe Ratio of 1.04. The chart below compares the historical Sharpe Ratios of WBIO.L and IUHC.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	WBIO.L	IUHC.L	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.91	1.04	+0.87
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.45	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.60	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.19	0.61	-0.80

Drawdowns

WBIO.L vs. IUHC.L - Drawdown Comparison

The maximum WBIO.L drawdown since its inception was -51.13%, which is greater than IUHC.L's maximum drawdown of -19.73%. Use the drawdown chart below to compare losses from any high point for WBIO.L and IUHC.L.

Drawdown Indicators

	WBIO.L	IUHC.L	Difference
Max Drawdown Largest peak-to-trough decline	-51.13%	-19.73%	-31.40%
Max Drawdown (1Y) Largest decline over 1 year	-11.50%	-11.67%	+0.17%
Max Drawdown (3Y) Largest decline over 3 years	-39.34%	-19.73%	-19.61%
Max Drawdown (5Y) Largest decline over 5 years	—	-19.73%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-19.73%	—
Current Drawdown Current decline from peak	-18.76%	-5.02%	-13.74%
Average Drawdown Average peak-to-trough decline	-26.35%	-4.71%	-21.64%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.89%	4.64%	+0.25%

Volatility

WBIO.L vs. IUHC.L - Volatility Comparison

WisdomTree BioRevolution UCITS ETF USD Acc (WBIO.L) has a higher volatility of 6.84% compared to iShares S&P 500 Health Care Sector UCITS ETF USD (Acc) (IUHC.L) at 5.56%. This indicates that WBIO.L's price experiences larger fluctuations and is considered to be riskier than IUHC.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	WBIO.L	IUHC.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.84%	5.56%	+1.28%
Volatility (6M) Calculated over the trailing 6-month period	17.06%	11.35%	+5.71%
Volatility (1Y) Calculated over the trailing 1-year period	26.57%	15.47%	+11.10%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	23.70%	15.17%	+8.53%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	23.70%	16.59%	+7.11%

WBIO.L vs. IUHC.L - Expense Ratio Comparison

WBIO.L has a 0.45% expense ratio, which is higher than IUHC.L's 0.15% expense ratio.

Dividends

WBIO.L vs. IUHC.L - Dividend Comparison

Neither WBIO.L nor IUHC.L has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both WBIO.L and IUHC.L in my portfolio?

WBIO.L and IUHC.L have a correlation of 0.51, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, WBIO.L or IUHC.L?

On fees, IUHC.L is cheaper at 0.15% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, WBIO.L or IUHC.L?

IUHC.L is cheaper with a 0.15% expense ratio, compared with 0.45% for WBIO.L.

What is the main difference between WBIO.L and IUHC.L?

WBIO.L tracks NASDAQ Biotechnology TR USD, while IUHC.L tracks S&P 500 Capped 35/20 Health Care Index. They also come from different issuers: WisdomTree and iShares. Their fees differ too: 0.45% for WBIO.L and 0.15% for IUHC.L.