TVTX vs. XBI

Last updated Jun 5, 2026

TVTX (Travere Therapeutics, Inc.) is a stock, while XBI (SPDR S&P Biotech ETF) is Health & Biotech Equities fund tracking the S&P Biotechnology Select Industry Index. Over the past 10 years, TVTX returned 9.86%/yr vs 8.53%/yr for XBI. A 0.55 correlation means they provide meaningful diversification when combined.

Performance

TVTX vs. XBI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Travere Therapeutics, Inc. (TVTX) and SPDR S&P Biotech ETF (XBI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TVTX achieves a 20.86% return, which is significantly higher than XBI's 9.42% return. Over the past 10 years, TVTX has outperformed XBI with an annualized return of 9.86%, while XBI has yielded a comparatively lower 8.53% annualized return.

TVTX

• 1D: 2.17%
• 1M: 3.08%
• YTD: 20.86%
• 6M: 30.71%
• 1Y: 203.42%
• 3Y*: 34.90%
• 5Y*: 26.76%
• 10Y*: 9.86%

XBI

• 1D: 2.77%
• 1M: -0.28%
• YTD: 9.42%
• 6M: 8.61%
• 1Y: 62.35%
• 3Y*: 15.65%
• 5Y*: 1.14%
• 10Y*: 8.53%

*Multi-year figures are annualized to reflect compound growth (CAGR)

TVTX vs. XBI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
TVTX Travere Therapeutics, Inc.	20.86%	119.35%	93.77%	-57.25%	-32.25%	13.89%	91.94%	-37.25%	7.40%	11.30%
XBI SPDR S&P Biotech ETF	9.42%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%

Correlation

The correlation between TVTX and XBI is 0.56, which is moderate. They share some common price drivers but move independently often enough to provide real diversification benefit when combined.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.56
Correlation (3Y) Calculated over the trailing 3-year period	0.56
Correlation (5Y) Calculated over the trailing 5-year period	0.59
Correlation (10Y) Calculated over the trailing 10-year period	0.59
Correlation (All Time) Calculated using the full available price history since Nov 9, 2012	0.55

The correlation between TVTX and XBI has been stable across timeframes, ranging from 0.55 to 0.59 - a consistent structural relationship.

Return for Risk

TVTX vs. XBI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TVTX

TVTX Risk / Return Rank: 93
TVTX Sharpe Ratio Rank: 94
TVTX Sortino Ratio Rank: 94
TVTX Omega Ratio Rank: 92
TVTX Calmar Ratio Rank: 94
TVTX Martin Ratio Rank: 92

XBI

XBI Risk / Return Rank: 80
XBI Sharpe Ratio Rank: 77
XBI Sortino Ratio Rank: 75
XBI Omega Ratio Rank: 67
XBI Calmar Ratio Rank: 93
XBI Martin Ratio Rank: 89

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TVTX vs. XBI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Travere Therapeutics, Inc. (TVTX) and SPDR S&P Biotech ETF (XBI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TVTX	XBI	Difference
Sharpe ratio: Return per unit of total volatility	2.86	2.45	+0.41
Sortino ratio: Return per unit of downside risk	3.81	3.32	+0.48
Omega ratio: Gain probability vs. loss probability	1.47	1.40	+0.08
Calmar ratio: Return relative to maximum drawdown	6.11	6.45	-0.33
Martin ratio: Return relative to average drawdown	14.11	19.53	-5.42
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TVTX vs. XBI - Sharpe Ratio Comparison

The current TVTX Sharpe Ratio is 2.86, which is comparable to the XBI Sharpe Ratio of 2.45. The chart below compares the historical Sharpe Ratios of TVTX and XBI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TVTX	XBI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.86	2.45	+0.41
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.40	0.04	+0.37
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.17	0.27	-0.10
Sharpe Ratio (All Time) Calculated using the full available price history	0.29	0.36	-0.07

Drawdowns

TVTX vs. XBI - Drawdown Comparison

The maximum TVTX drawdown since its inception was -85.43%, which is greater than XBI's maximum drawdown of -63.89%. Use the drawdown chart below to compare losses from any high point for TVTX and XBI.

Drawdown Indicators

	TVTX	XBI	Difference
Max Drawdown Largest peak-to-trough decline	-85.43%	-63.89%	-21.54%
Max Drawdown (1Y) Largest decline over 1 year	-33.49%	-9.72%	-23.77%
Max Drawdown (3Y) Largest decline over 3 years	-72.80%	-32.99%	-39.81%
Max Drawdown (5Y) Largest decline over 5 years	-83.12%	-54.71%	-28.41%
Max Drawdown (10Y) Largest decline over 10 years	-83.64%	-63.89%	-19.75%
Current Drawdown Current decline from peak	-3.31%	-22.89%	+19.58%
Average Drawdown Average peak-to-trough decline	-41.15%	-20.93%	-20.22%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.49%	3.20%	+11.29%

Volatility

TVTX vs. XBI - Volatility Comparison

Travere Therapeutics, Inc. (TVTX) has a higher volatility of 14.86% compared to SPDR S&P Biotech ETF (XBI) at 9.69%. This indicates that TVTX's price experiences larger fluctuations and is considered to be riskier than XBI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TVTX	XBI	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.86%	9.69%	+5.17%
Volatility (6M) Calculated over the trailing 6-month period	51.89%	20.31%	+31.58%
Volatility (1Y) Calculated over the trailing 1-year period	71.70%	25.60%	+46.10%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	66.43%	32.20%	+34.23%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	58.32%	32.00%	+26.32%

Dividends

TVTX vs. XBI - Dividend Comparison

TVTX has not paid dividends to shareholders, while XBI's dividend yield for the trailing twelve months is around 0.33%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
TVTX Travere Therapeutics, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XBI SPDR S&P Biotech ETF	0.33%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%

Frequently Asked Questions

Can I hold both TVTX and XBI in my portfolio?

TVTX and XBI have a correlation of 0.56, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TVTX or XBI?

TVTX has higher volatility (14.86%) compared to XBI (9.69%). In terms of maximum drawdown, TVTX dropped -85.43% vs XBI's -63.89%.

Which has better risk-adjusted returns?

TVTX currently has the higher Sharpe Ratio (2.86 vs 2.45), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.