RYTM vs. SMMT

Last updated Jun 9, 2026

RYTM (Rhythm Pharmaceuticals, Inc.) and SMMT (Summit Therapeutics Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, RYTM returned 35.24%/yr vs 13.84%/yr for SMMT. At a 0.21 correlation, their price movements are largely independent.

Performance

RYTM vs. SMMT - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Rhythm Pharmaceuticals, Inc. (RYTM) and Summit Therapeutics Inc. (SMMT). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both investments are quite close, with RYTM having a -19.73% return and SMMT slightly higher at -19.33%.

RYTM

• 1D: -0.55%
• 1M: -8.76%
• YTD: -19.73%
• 6M: -18.31%
• 1Y: 26.16%
• 3Y*: 70.19%
• 5Y*: 35.24%
• 10Y*: —

SMMT

• 1D: -4.47%
• 1M: -21.96%
• YTD: -19.33%
• 6M: -24.24%
• 1Y: -31.47%
• 3Y*: 100.52%
• 5Y*: 13.84%
• 10Y*: 4.15%

*Multi-year figures are annualized to reflect compound growth (CAGR)

RYTM vs. SMMT - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
RYTM Rhythm Pharmaceuticals, Inc.	-19.73%	91.21%	21.78%	57.86%	191.78%	-66.43%	29.49%	-14.58%	-7.50%	25.20%
SMMT Summit Therapeutics Inc.	-19.33%	-1.99%	583.72%	-38.59%	57.99%	-42.77%	193.75%	39.13%	-89.62%	-11.29%

Correlation

The correlation between RYTM and SMMT is 0.25, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.25
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.25
Correlation (All Time) Calculated using the full available price history since Oct 5, 2017	0.21

Fundamentals

Market Cap RYTM : $5.84B SMMT : $10.94B
EPS RYTM : -$3.10 SMMT : -$1.60
PB Ratio RYTM : 712.63 SMMT : 20.04
Total Revenue (TTM) RYTM : $217.17M SMMT : $0.00
Gross Profit (TTM) RYTM : $194.16M SMMT : -$83.36K
EBITDA (TTM) RYTM : -$182.86M SMMT : -$738.34M

Return for Risk

RYTM vs. SMMT — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

RYTM

RYTM Risk / Return Rank: 60
RYTM Sharpe Ratio Rank: 58
RYTM Sortino Ratio Rank: 62
RYTM Omega Ratio Rank: 59
RYTM Calmar Ratio Rank: 59
RYTM Martin Ratio Rank: 59

SMMT

SMMT Risk / Return Rank: 25
SMMT Sharpe Ratio Rank: 24
SMMT Sortino Ratio Rank: 28
SMMT Omega Ratio Rank: 28
SMMT Calmar Ratio Rank: 21
SMMT Martin Ratio Rank: 24

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

RYTM vs. SMMT - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Rhythm Pharmaceuticals, Inc. (RYTM) and Summit Therapeutics Inc. (SMMT). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	RYTM	SMMT	Difference
Sharpe ratio: Return per unit of total volatility	0.46	-0.42	+0.88
Sortino ratio: Return per unit of downside risk	1.27	-0.15	+1.42
Omega ratio: Gain probability vs. loss probability	1.15	0.98	+0.17
Calmar ratio: Return relative to maximum drawdown	0.74	-0.60	+1.34
Martin ratio: Return relative to average drawdown	1.74	-0.92	+2.66
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

RYTM vs. SMMT - Sharpe Ratio Comparison

The current RYTM Sharpe Ratio is 0.46, which is higher than the SMMT Sharpe Ratio of -0.42. The chart below compares the historical Sharpe Ratios of RYTM and SMMT, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	RYTM	SMMT	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.46	-0.42	+0.88
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.46	0.08	+0.39
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.03	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.18	0.02	+0.16

Drawdowns

RYTM vs. SMMT - Drawdown Comparison

The maximum RYTM drawdown since its inception was -92.10%, roughly equal to the maximum SMMT drawdown of -95.75%. Use the drawdown chart below to compare losses from any high point for RYTM and SMMT.

Drawdown Indicators

	RYTM	SMMT	Difference
Max Drawdown Largest peak-to-trough decline	-92.10%	-95.75%	+3.65%
Max Drawdown (1Y) Largest decline over 1 year	-35.54%	-52.76%	+17.22%
Max Drawdown (3Y) Largest decline over 3 years	-35.54%	-62.26%	+26.72%
Max Drawdown (5Y) Largest decline over 5 years	-85.49%	-91.78%	+6.29%
Max Drawdown (10Y) Largest decline over 10 years	—	-95.75%	—
Current Drawdown Current decline from peak	-26.95%	-61.55%	+34.60%
Average Drawdown Average peak-to-trough decline	-32.18%	-57.64%	+25.46%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.08%	34.32%	-19.24%

Volatility

RYTM vs. SMMT - Volatility Comparison

The current volatility for Rhythm Pharmaceuticals, Inc. (RYTM) is 14.47%, while Summit Therapeutics Inc. (SMMT) has a volatility of 22.47%. This indicates that RYTM experiences smaller price fluctuations and is considered to be less risky than SMMT based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	RYTM	SMMT	Difference
Volatility (1M) Calculated over the trailing 1-month period	14.47%	22.47%	-8.00%
Volatility (6M) Calculated over the trailing 6-month period	36.66%	56.53%	-19.87%
Volatility (1Y) Calculated over the trailing 1-year period	57.36%	75.95%	-18.59%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	76.40%	185.12%	-108.72%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	70.96%	144.63%	-73.67%

Dividends

RYTM vs. SMMT - Dividend Comparison

Neither RYTM nor SMMT has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both RYTM and SMMT in my portfolio?

RYTM and SMMT have a correlation of 0.25, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, RYTM or SMMT?

SMMT has higher volatility (22.47%) compared to RYTM (14.47%). In terms of maximum drawdown, RYTM dropped -92.10% vs SMMT's -95.75%.

Which has better risk-adjusted returns?

RYTM currently has the higher Sharpe Ratio (0.46 vs -0.42), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.