PSNL vs. ANRO

Last updated Apr 1, 2026

Compare and contrast key facts about Personalis, Inc. (PSNL) and Alto Neuroscience, Inc (ANRO).

Performance

PSNL vs. ANRO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Personalis, Inc. (PSNL) and Alto Neuroscience, Inc (ANRO). The values are adjusted to include any dividend payments, if applicable.

PSNL vs. ANRO - Yearly Performance Comparison

	2026 (YTD)	2025	2024
PSNL Personalis, Inc.	-19.97%	37.72%	337.88%
ANRO Alto Neuroscience, Inc	26.29%	320.80%	-79.57%

Fundamentals

Market Cap PSNL : $587.83M ANRO : $717.64M
EPS PSNL : -$0.90 ANRO : -$2.20
PB Ratio PSNL : 2.25 ANRO : 4.75
Total Revenue (TTM) PSNL : $52.30M ANRO : $0.00
Gross Profit (TTM) PSNL : -$1.57M ANRO : -$421.00K
EBITDA (TTM) PSNL : -$75.05M ANRO : -$61.63M

Returns By Period

In the year-to-date period, PSNL achieves a -19.97% return, which is significantly lower than ANRO's 26.29% return.

PSNL

• 1D: 2.08%
• 1M: -29.69%
• YTD: -19.97%
• 6M: -2.30%
• 1Y: 81.48%
• 3Y*: 32.15%
• 5Y*: -23.38%
• 10Y*: —

ANRO

• 1D: 12.51%
• 1M: 14.17%
• YTD: 26.29%
• 6M: 459.20%
• 1Y: 940.74%
• 3Y*: —
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

PSNL vs. ANRO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PSNL

PSNL Risk / Return Rank: 72
PSNL Sharpe Ratio Rank: 71
PSNL Sortino Ratio Rank: 73
PSNL Omega Ratio Rank: 71
PSNL Calmar Ratio Rank: 74
PSNL Martin Ratio Rank: 71

ANRO

ANRO Risk / Return Rank: 99
ANRO Sharpe Ratio Rank: 100
ANRO Sortino Ratio Rank: 99
ANRO Omega Ratio Rank: 98
ANRO Calmar Ratio Rank: 100
ANRO Martin Ratio Rank: 100

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PSNL vs. ANRO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Personalis, Inc. (PSNL) and Alto Neuroscience, Inc (ANRO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	PSNL	ANRO	Difference
Sharpe ratio Return per unit of total volatility	0.89	7.25	-6.36
Sortino ratio Return per unit of downside risk	1.73	5.65	-3.92
Omega ratio Gain probability vs. loss probability	1.22	1.71	-0.49
Calmar ratio Return relative to maximum drawdown	1.71	30.09	-28.38
Martin ratio Return relative to average drawdown	3.63	72.94	-69.31
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

PSNL vs. ANRO - Sharpe Ratio Comparison

The current PSNL Sharpe Ratio is 0.89, which is lower than the ANRO Sharpe Ratio of 7.25. The chart below compares the historical Sharpe Ratios of PSNL and ANRO, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	PSNL	ANRO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.89	7.25	-6.36
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.23	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.20	0.03	-0.24

Correlation

The correlation between PSNL and ANRO is 0.21, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

PSNL vs. ANRO - Dividend Comparison

Neither PSNL nor ANRO has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

PSNL vs. ANRO - Drawdown Comparison

The maximum PSNL drawdown since its inception was -98.18%, which is greater than ANRO's maximum drawdown of -91.74%. Use the drawdown chart below to compare losses from any high point for PSNL and ANRO.

Drawdown Indicators

	PSNL	ANRO	Difference
Max Drawdown Largest peak-to-trough decline	-98.18%	-91.74%	-6.44%
Max Drawdown (1Y) Largest decline over 1 year	-44.53%	-29.59%	-14.94%
Max Drawdown (5Y) Largest decline over 5 years	-96.65%	—	—
Current Drawdown Current decline from peak	-87.51%	-7.45%	-80.06%
Average Drawdown Average peak-to-trough decline	-75.47%	-56.91%	-18.56%
Ulcer Index Depth and duration of drawdowns from previous peaks	20.93%	12.21%	+8.72%

Volatility

PSNL vs. ANRO - Volatility Comparison

Personalis, Inc. (PSNL) has a higher volatility of 28.36% compared to Alto Neuroscience, Inc (ANRO) at 24.93%. This indicates that PSNL's price experiences larger fluctuations and is considered to be riskier than ANRO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PSNL	ANRO	Difference
Volatility (1M) Calculated over the trailing 1-month period	28.36%	24.93%	+3.43%
Volatility (6M) Calculated over the trailing 6-month period	71.91%	98.02%	-26.11%
Volatility (1Y) Calculated over the trailing 1-year period	92.48%	131.26%	-38.78%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	102.53%	118.76%	-16.23%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	98.12%	118.76%	-20.64%

Financials