PHPIX vs. USPIX

Last updated Jul 17, 2026

PHPIX (ProFunds Pharmaceuticals UltraSector Fund) and USPIX (ProFunds UltraShort NASDAQ-100 Fund) are both mutual funds - PHPIX is a Leveraged Equities fund managed by ProFunds, while USPIX is a Inverse Equities fund managed by ProFunds. Over the past 10 years, PHPIX returned 7.73%/yr vs -39.42%/yr for USPIX. At a correlation of -0.52, they often move in opposite directions. PHPIX charges 1.78%/yr vs 1.68%/yr for USPIX.

Performance

PHPIX vs. USPIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ProFunds Pharmaceuticals UltraSector Fund (PHPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, PHPIX achieves a 29.16% return, which is significantly higher than USPIX's -28.74% return. Over the past 10 years, PHPIX has outperformed USPIX with an annualized return of 7.73%, while USPIX has yielded a comparatively lower -39.42% annualized return.

PHPIX

• 1D: 1.71%
• 1M: 19.05%
• 6M: 29.95%
• YTD: 29.16%
• 1Y: 92.81%
• 3Y*: 22.50%
• 5Y*: 12.35%
• 10Y*: 7.73%

USPIX

• 1D: 0.62%
• 1M: 2.53%
• 6M: -27.23%
• YTD: -28.74%
• 1Y: -40.62%
• 3Y*: -37.05%
• 5Y*: -31.48%
• 10Y*: -39.42%

*Multi-year figures are annualized to reflect compound growth (CAGR)

PHPIX vs. USPIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
PHPIX ProFunds Pharmaceuticals UltraSector Fund	29.16%	41.41%	1.36%	-11.28%	-10.73%	28.10%	15.48%	19.98%	-14.91%	10.19%
USPIX ProFunds UltraShort NASDAQ-100 Fund	-28.74%	-35.26%	-38.20%	-57.06%	61.80%	-46.20%	-70.91%	-50.15%	-9.56%	-44.56%

Correlation

The correlation between PHPIX and USPIX is -0.32, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.32
Correlation (3Y) Calculated over the trailing 3-year period	-0.40
Correlation (5Y) Calculated over the trailing 5-year period	-0.45
Correlation (10Y) Calculated over the trailing 10-year period	-0.49
Correlation (All Time) Calculated using the full available price history since Jun 28, 2000	-0.52

Over the past year, the inverse relationship between PHPIX and USPIX has weakened: their correlation has moved from -0.52 to -0.32, meaning they move in opposite directions less often than they have historically.

Return for Risk

PHPIX vs. USPIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

PHPIX

PHPIX Risk / Return Rank: 92
PHPIX Sharpe Ratio Rank: 97
PHPIX Sortino Ratio Rank: 88
PHPIX Omega Ratio Rank: 83
PHPIX Calmar Ratio Rank: 97
PHPIX Martin Ratio Rank: 96

USPIX

USPIX Risk / Return Rank: 0
USPIX Sharpe Ratio Rank: 0
USPIX Sortino Ratio Rank: 0
USPIX Omega Ratio Rank: 0
USPIX Calmar Ratio Rank: 0
USPIX Martin Ratio Rank: 0

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

PHPIX vs. USPIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ProFunds Pharmaceuticals UltraSector Fund (PHPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	PHPIX	USPIX	Difference
Sharpe ratio: Return per unit of total volatility	2.93	-1.10	+4.03
Sortino ratio: Return per unit of downside risk	3.60	-1.71	+5.31
Omega ratio: Gain probability vs. loss probability	1.44	0.82	+0.62
Calmar ratio: Return relative to maximum drawdown	5.46	-0.91	+6.37
Martin ratio: Return relative to average drawdown	18.92	-1.75	+20.67

PHPIX vs. USPIX - Sharpe Ratio Comparison

The current PHPIX Sharpe Ratio is 2.93, which is higher than the USPIX Sharpe Ratio of -1.10. The chart below compares the historical Sharpe Ratios of PHPIX and USPIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

PHPIX vs. USPIX - Drawdown Comparison

The maximum PHPIX drawdown since its inception was -77.37%, smaller than the maximum USPIX drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for PHPIX and USPIX.

Drawdown Indicators

	PHPIX	USPIX	Difference
Max Drawdown Largest peak-to-trough decline	-77.37%	-100.00%	+22.63%
Max Drawdown (1Y) Largest decline over 1 year	-17.65%	-45.06%	+27.41%
Max Drawdown (3Y) Largest decline over 3 years	-35.00%	-80.96%	+45.96%
Max Drawdown (5Y) Largest decline over 5 years	-39.21%	-89.53%	+50.32%
Max Drawdown (10Y) Largest decline over 10 years	-45.46%	-99.37%	+53.91%
Current Drawdown Current decline from peak	-4.77%	-100.00%	+95.23%
Average Drawdown Average peak-to-trough decline	-31.57%	-96.44%	+64.87%
Ulcer Index Depth and duration of drawdowns from previous peaks	5.09%	23.30%	-18.21%

Volatility

PHPIX vs. USPIX - Volatility Comparison

The current volatility for ProFunds Pharmaceuticals UltraSector Fund (PHPIX) is 10.27%, while ProFunds UltraShort NASDAQ-100 Fund (USPIX) has a volatility of 15.59%. This indicates that PHPIX experiences smaller price fluctuations and is considered to be less risky than USPIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	PHPIX	USPIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	10.27%	15.59%	-5.32%
Volatility (6M) Calculated over the trailing 6-month period	25.64%	30.47%	-4.83%
Volatility (1Y) Calculated over the trailing 1-year period	33.08%	37.07%	-3.99%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	28.70%	45.96%	-17.26%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	28.07%	44.63%	-16.56%

PHPIX vs. USPIX - Expense Ratio Comparison

PHPIX has a 1.78% expense ratio, which is higher than USPIX's 1.68% expense ratio.

Dividends

PHPIX vs. USPIX - Dividend Comparison

PHPIX's dividend yield for the trailing twelve months is around 0.69%, less than USPIX's 3.80% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
PHPIX ProFunds Pharmaceuticals UltraSector Fund	0.69%	0.89%	1.06%	0.48%	0.00%	11.83%	0.38%	0.00%	4.17%	0.00%	0.00%	0.08%
USPIX ProFunds UltraShort NASDAQ-100 Fund	3.80%	2.71%	0.00%	5.92%	0.00%	0.00%	0.07%	0.36%	0.00%	0.00%	0.00%	0.00%

Frequently Asked Questions

Can I hold both PHPIX and USPIX in my portfolio?

PHPIX and USPIX have a correlation of -0.32, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, PHPIX or USPIX?

USPIX has higher volatility (15.59%) compared to PHPIX (10.27%). In terms of maximum drawdown, PHPIX dropped -77.37% vs USPIX's -100.00%.

Which has better risk-adjusted returns?

PHPIX currently has the higher Sharpe Ratio (2.93 vs -1.10), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.