LIXT vs. MRK
LIXT (Lixte Biotechnology Holdings, Inc.) and MRK (Merck & Co., Inc.) are both stocks. Both are in the Healthcare sector — LIXT in Biotechnology, MRK in Drug Manufacturers - General. Over the past 10 years, LIXT returned -4.85%/yr vs 11.81%/yr for MRK. At a 0.01 correlation, their price movements are largely independent.
Performance
LIXT vs. MRK - Performance Comparison
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Returns By Period
In the year-to-date period, LIXT achieves a 85.75% return, which is significantly higher than MRK's 15.47% return. Over the past 10 years, LIXT has underperformed MRK with an annualized return of -4.85%, while MRK has yielded a comparatively higher 11.81% annualized return.
LIXT
- 1D
- -2.41%
- 1M
- 24.15%
- YTD
- 85.75%
- 6M
- 78.48%
- 1Y
- 826.87%
- 3Y*
- 12.11%
- 5Y*
- -24.32%
- 10Y*
- -4.85%
MRK
- 1D
- 3.57%
- 1M
- -1.44%
- YTD
- 15.47%
- 6M
- 15.71%
- 1Y
- 54.44%
- 3Y*
- 4.66%
- 5Y*
- 12.89%
- 10Y*
- 11.81%
LIXT vs. MRK - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
LIXT Lixte Biotechnology Holdings, Inc. | 85.75% | 93.62% | -13.63% | -53.83% | -57.23% | -62.46% | -22.30% | -26.92% | 463.94% | 17.77% |
MRK Merck & Co., Inc. | 15.47% | 9.79% | -6.26% | 1.01% | 49.42% | 1.75% | -7.20% | 22.27% | 39.95% | -1.49% |
Correlation
The correlation between LIXT and MRK is -0.06, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.
| Correlation | |
|---|---|
Correlation (1Y) Calculated over the trailing 1-year period | -0.06 |
Correlation (3Y) Calculated over the trailing 3-year period | -0.01 |
Correlation (5Y) Calculated over the trailing 5-year period | 0.01 |
Correlation (10Y) Calculated over the trailing 10-year period | 0.00 |
Correlation (All Time) Calculated using the full available price history since Apr 8, 2010 | 0.01 |
Fundamentals
LIXT:
-$0.93
MRK:
$3.58
LIXT:
$0.00
MRK:
$65.59B
LIXT:
$0.00
MRK:
$49.79B
LIXT:
-$2.80M
MRK:
$22.69B
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Return for Risk
LIXT vs. MRK — Risk / Return Rank
LIXT
MRK
LIXT vs. MRK - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Lixte Biotechnology Holdings, Inc. (LIXT) and Merck & Co., Inc. (MRK). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.
| LIXT | MRK | Difference | |
|---|---|---|---|
| Sharpe ratioReturn per unit of total volatility | +3.74 | ||
| Sortino ratioReturn per unit of downside risk | +2.26 | ||
| Omega ratioGain probability vs. loss probability | 1.60 | 1.35 | +0.25 |
| Calmar ratioReturn relative to maximum drawdown | 14.07 | 4.81 | +9.25 |
| Martin ratioReturn relative to average drawdown | 26.04 | 11.86 | +14.18 |
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Drawdowns
LIXT vs. MRK - Drawdown Comparison
The maximum LIXT drawdown since its inception was -99.12%, which is greater than MRK's maximum drawdown of -68.61%. Use the drawdown chart below to compare losses from any high point for LIXT and MRK.
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Drawdown Indicators
| LIXT | MRK | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -99.12% | -68.61% | -30.51% |
Max Drawdown (1Y)Largest decline over 1 year | -59.37% | -11.37% | -48.00% |
Max Drawdown (3Y)Largest decline over 3 years | -90.51% | -43.44% | -47.07% |
Max Drawdown (5Y)Largest decline over 5 years | -97.80% | -43.44% | -54.36% |
Max Drawdown (10Y)Largest decline over 10 years | -99.12% | -43.44% | -55.68% |
Current DrawdownCurrent decline from peak | -90.99% | -3.75% | -87.24% |
Average DrawdownAverage peak-to-trough decline | -65.22% | -18.83% | -46.39% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 32.01% | 4.60% | +27.41% |
Volatility
LIXT vs. MRK - Volatility Comparison
Lixte Biotechnology Holdings, Inc. (LIXT) has a higher volatility of 31.60% compared to Merck & Co., Inc. (MRK) at 10.08%. This indicates that LIXT's price experiences larger fluctuations and is considered to be riskier than MRK based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| LIXT | MRK | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 31.60% | 10.08% | +21.52% |
Volatility (6M)Calculated over the trailing 6-month period | 69.39% | 18.39% | +51.00% |
Volatility (1Y)Calculated over the trailing 1-year period | 145.43% | 27.30% | +118.13% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 136.15% | 23.77% | +112.38% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 170.70% | 22.97% | +147.73% |
Dividends
LIXT vs. MRK - Dividend Comparison
LIXT has not paid dividends to shareholders, while MRK's dividend yield for the trailing twelve months is around 2.97%.
| Position | TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
LIXT Lixte Biotechnology Holdings, Inc. | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
MRK Merck & Co., Inc. | 2.97% | 3.12% | 3.14% | 2.72% | 2.52% | 3.41% | 3.03% | 2.48% | 2.60% | 3.36% | 3.14% | 3.43% |
Financials
LIXT vs. MRK - Financials Comparison
This section allows you to compare key financial metrics between Lixte Biotechnology Holdings, Inc. and Merck & Co., Inc.. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
Frequently Asked Questions
LIXT and MRK have a correlation of -0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.
LIXT has higher volatility (31.60%) compared to MRK (10.08%). In terms of maximum drawdown, LIXT dropped -99.12% vs MRK's -68.61%.
LIXT currently has the higher Sharpe Ratio (5.74 vs 2.01), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.
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