KOD vs. AVXL

Last updated Apr 1, 2026

Compare and contrast key facts about Kodiak Sciences Inc. (KOD) and Anavex Life Sciences Corp. (AVXL).

Performance

KOD vs. AVXL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Kodiak Sciences Inc. (KOD) and Anavex Life Sciences Corp. (AVXL). The values are adjusted to include any dividend payments, if applicable.

KOD vs. AVXL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
KOD Kodiak Sciences Inc.	36.34%	181.01%	227.30%	-57.54%	-91.55%	-42.29%	104.18%	913.38%	-30.12%
AVXL Anavex Life Sciences Corp.	-13.76%	-66.85%	15.36%	0.54%	-46.60%	221.11%	108.49%	66.03%	-37.35%

Fundamentals

EPS KOD : -$4.11 AVXL : -$0.46
Total Revenue (TTM) KOD : $0.00 AVXL : $0.00
Gross Profit (TTM) KOD : -$26.49M AVXL : $0.00
EBITDA (TTM) KOD : -$190.85M AVXL : -$28.87M

Returns By Period

In the year-to-date period, KOD achieves a 36.34% return, which is significantly higher than AVXL's -13.76% return.

KOD

• 1D: 13.25%
• 1M: 42.24%
• YTD: 36.34%
• 6M: 132.86%
• 1Y: 1,259.00%
• 3Y*: 83.20%
• 5Y*: -18.97%
• 10Y*: —

AVXL

• 1D: 8.87%
• 1M: -30.70%
• YTD: -13.76%
• 6M: -65.51%
• 1Y: -64.22%
• 3Y*: -28.98%
• 5Y*: -27.55%
• 10Y*: -4.82%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

KOD vs. AVXL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

KOD

KOD Risk / Return Rank: 99
KOD Sharpe Ratio Rank: 100
KOD Sortino Ratio Rank: 99
KOD Omega Ratio Rank: 98
KOD Calmar Ratio Rank: 100
KOD Martin Ratio Rank: 100

AVXL

AVXL Risk / Return Rank: 12
AVXL Sharpe Ratio Rank: 11
AVXL Sortino Ratio Rank: 13
AVXL Omega Ratio Rank: 11
AVXL Calmar Ratio Rank: 12
AVXL Martin Ratio Rank: 12

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

KOD vs. AVXL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Kodiak Sciences Inc. (KOD) and Anavex Life Sciences Corp. (AVXL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	KOD	AVXL	Difference
Sharpe ratio Return per unit of total volatility	8.92	-0.72	+9.64
Sortino ratio Return per unit of downside risk	5.47	-0.87	+6.34
Omega ratio Gain probability vs. loss probability	1.66	0.87	+0.79
Calmar ratio Return relative to maximum drawdown	37.34	-0.81	+38.16
Martin ratio Return relative to average drawdown	73.29	-1.40	+74.70
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

KOD vs. AVXL - Sharpe Ratio Comparison

The current KOD Sharpe Ratio is 8.92, which is higher than the AVXL Sharpe Ratio of -0.72. The chart below compares the historical Sharpe Ratios of KOD and AVXL, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	KOD	AVXL	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	8.92	-0.72	+9.64
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.18	-0.33	+0.16
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	-0.06	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.19	-0.05	+0.24

Correlation

The correlation between KOD and AVXL is 0.37, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

KOD vs. AVXL - Dividend Comparison

Neither KOD nor AVXL has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

KOD vs. AVXL - Drawdown Comparison

The maximum KOD drawdown since its inception was -99.15%, roughly equal to the maximum AVXL drawdown of -97.06%. Use the drawdown chart below to compare losses from any high point for KOD and AVXL.

Drawdown Indicators

	KOD	AVXL	Difference
Max Drawdown Largest peak-to-trough decline	-99.15%	-97.06%	-2.09%
Max Drawdown (1Y) Largest decline over 1 year	-32.40%	-79.57%	+47.17%
Max Drawdown (5Y) Largest decline over 5 years	-98.91%	-90.51%	-8.40%
Max Drawdown (10Y) Largest decline over 10 years	—	-90.51%	—
Current Drawdown Current decline from peak	-76.82%	-89.36%	+12.54%
Average Drawdown Average peak-to-trough decline	-63.68%	-64.88%	+1.20%
Ulcer Index Depth and duration of drawdowns from previous peaks	16.51%	46.14%	-29.63%

Volatility

KOD vs. AVXL - Volatility Comparison

Kodiak Sciences Inc. (KOD) has a higher volatility of 61.06% compared to Anavex Life Sciences Corp. (AVXL) at 47.17%. This indicates that KOD's price experiences larger fluctuations and is considered to be riskier than AVXL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	KOD	AVXL	Difference
Volatility (1M) Calculated over the trailing 1-month period	61.06%	47.17%	+13.89%
Volatility (6M) Calculated over the trailing 6-month period	87.44%	82.27%	+5.17%
Volatility (1Y) Calculated over the trailing 1-year period	142.85%	88.81%	+54.04%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	108.72%	83.16%	+25.56%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	104.86%	85.60%	+19.26%

Financials