HCPIX vs. USPIX

Last updated Jul 14, 2026

HCPIX (ProFunds UltraSector Health Care Fund) and USPIX (ProFunds UltraShort NASDAQ-100 Fund) are both mutual funds - HCPIX is a Leveraged Equities fund managed by ProFunds, while USPIX is a Inverse Equities fund managed by ProFunds. Over the past 10 years, HCPIX returned 9.31%/yr vs -39.58%/yr for USPIX. At a correlation of -0.61, they often move in opposite directions. HCPIX charges 1.61%/yr vs 1.68%/yr for USPIX.

Performance

HCPIX vs. USPIX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in ProFunds UltraSector Health Care Fund (HCPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, HCPIX achieves a 4.77% return, which is significantly higher than USPIX's -30.25% return. Over the past 10 years, HCPIX has outperformed USPIX with an annualized return of 9.31%, while USPIX has yielded a comparatively lower -39.58% annualized return.

HCPIX

• 1D: -1.24%
• 1M: 7.34%
• 6M: 2.33%
• YTD: 4.77%
• 1Y: 26.89%
• 3Y*: 8.35%
• 5Y*: 3.34%
• 10Y*: 9.31%

USPIX

• 1D: -0.63%
• 1M: -2.12%
• 6M: -27.42%
• YTD: -30.25%
• 1Y: -42.41%
• 3Y*: -38.71%
• 5Y*: -31.51%
• 10Y*: -39.58%

*Multi-year figures are annualized to reflect compound growth (CAGR)

HCPIX vs. USPIX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
HCPIX ProFunds UltraSector Health Care Fund	4.77%	16.02%	-1.37%	-1.30%	-10.60%	33.92%	16.86%	28.41%	4.96%	19.48%
USPIX ProFunds UltraShort NASDAQ-100 Fund	-30.25%	-35.26%	-38.20%	-57.06%	61.80%	-46.20%	-70.91%	-50.15%	-9.56%	-44.56%

Correlation

The correlation between HCPIX and USPIX is -0.06, meaning there is essentially no relationship between their price movements. Each responds to its own set of market drivers, making them strong candidates for combining in a diversified portfolio.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.06
Correlation (3Y) Calculated over the trailing 3-year period	-0.25
Correlation (5Y) Calculated over the trailing 5-year period	-0.43
Correlation (10Y) Calculated over the trailing 10-year period	-0.54
Correlation (All Time) Calculated using the full available price history since Jun 19, 2000	-0.61

Over the past year, the inverse relationship between HCPIX and USPIX has weakened: their correlation has moved from -0.61 to -0.06, meaning they move in opposite directions less often than they have historically.

Return for Risk

HCPIX vs. USPIX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

HCPIX

HCPIX Risk / Return Rank: 26
HCPIX Sharpe Ratio Rank: 25
HCPIX Sortino Ratio Rank: 30
HCPIX Omega Ratio Rank: 24
HCPIX Calmar Ratio Rank: 30
HCPIX Martin Ratio Rank: 20

USPIX

USPIX Risk / Return Rank: 0
USPIX Sharpe Ratio Rank: 0
USPIX Sortino Ratio Rank: 0
USPIX Omega Ratio Rank: 0
USPIX Calmar Ratio Rank: 0
USPIX Martin Ratio Rank: 0

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

HCPIX vs. USPIX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for ProFunds UltraSector Health Care Fund (HCPIX) and ProFunds UltraShort NASDAQ-100 Fund (USPIX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	HCPIX	USPIX	Difference
Sharpe ratio: Return per unit of total volatility	1.07	-1.15	+2.22
Sortino ratio: Return per unit of downside risk	1.74	-1.81	+3.55
Omega ratio: Gain probability vs. loss probability	1.19	0.80	+0.39
Calmar ratio: Return relative to maximum drawdown	1.57	-0.94	+2.51
Martin ratio: Return relative to average drawdown	3.64	-1.85	+5.48

HCPIX vs. USPIX - Sharpe Ratio Comparison

The current HCPIX Sharpe Ratio is 1.07, which is higher than the USPIX Sharpe Ratio of -1.15. The chart below compares the historical Sharpe Ratios of HCPIX and USPIX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

HCPIX vs. USPIX - Drawdown Comparison

The maximum HCPIX drawdown since its inception was -64.90%, smaller than the maximum USPIX drawdown of -100.00%. Use the drawdown chart below to compare losses from any high point for HCPIX and USPIX.

Drawdown Indicators

	HCPIX	USPIX	Difference
Max Drawdown Largest peak-to-trough decline	-64.90%	-100.00%	+35.10%
Max Drawdown (1Y) Largest decline over 1 year	-16.12%	-45.06%	+28.94%
Max Drawdown (3Y) Largest decline over 3 years	-27.68%	-80.96%	+53.28%
Max Drawdown (5Y) Largest decline over 5 years	-27.68%	-89.53%	+61.85%
Max Drawdown (10Y) Largest decline over 10 years	-40.66%	-99.37%	+58.71%
Current Drawdown Current decline from peak	-3.34%	-100.00%	+96.66%
Average Drawdown Average peak-to-trough decline	-20.95%	-96.44%	+75.49%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.97%	22.87%	-15.90%

Volatility

HCPIX vs. USPIX - Volatility Comparison

The current volatility for ProFunds UltraSector Health Care Fund (HCPIX) is 9.13%, while ProFunds UltraShort NASDAQ-100 Fund (USPIX) has a volatility of 16.92%. This indicates that HCPIX experiences smaller price fluctuations and is considered to be less risky than USPIX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	HCPIX	USPIX	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.13%	16.92%	-7.79%
Volatility (6M) Calculated over the trailing 6-month period	17.41%	30.22%	-12.81%
Volatility (1Y) Calculated over the trailing 1-year period	23.73%	36.80%	-13.07%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	22.64%	45.90%	-23.26%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	25.08%	44.60%	-19.52%

HCPIX vs. USPIX - Expense Ratio Comparison

HCPIX has a 1.61% expense ratio, which is lower than USPIX's 1.68% expense ratio.

Dividends

HCPIX vs. USPIX - Dividend Comparison

HCPIX's dividend yield for the trailing twelve months is around 0.16%, less than USPIX's 3.88% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018
HCPIX ProFunds UltraSector Health Care Fund	0.16%	0.17%	0.82%	0.26%	0.00%	0.00%	0.00%	0.05%	0.03%
USPIX ProFunds UltraShort NASDAQ-100 Fund	3.88%	2.71%	0.00%	5.92%	0.00%	0.00%	0.07%	0.36%	0.00%

Frequently Asked Questions

Can I hold both HCPIX and USPIX in my portfolio?

HCPIX and USPIX have a correlation of -0.06, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, HCPIX or USPIX?

USPIX has higher volatility (16.92%) compared to HCPIX (9.13%). In terms of maximum drawdown, HCPIX dropped -64.90% vs USPIX's -100.00%.

Which has better risk-adjusted returns?

HCPIX currently has the higher Sharpe Ratio (1.07 vs -1.15), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.