GNOM.L vs. XSHC.L

Last updated Jul 16, 2026

GNOM.L (Global X Genomics & Biotechnology UCITS ETF) and XSHC.L (Xtrackers MSCI USA Health Care UCITS ETF 1D) are both Health & Biotech Equities funds - GNOM.L tracks the Global X Genomics & Biotechnology UCITS ETF while XSHC.L tracks the MSCI World/Health Care NR USD. Both are passively managed. Over the past 3 years, GNOM.L returned 4.58%/yr vs 8.11%/yr for XSHC.L. At a 0.47 correlation, their price movements are largely independent. GNOM.L charges 0.50%/yr vs 0.12%/yr for XSHC.L.

Performance

GNOM.L vs. XSHC.L - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Global X Genomics & Biotechnology UCITS ETF (GNOM.L) and Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

GNOM.L is traded in USD, while XSHC.L is traded in GBp. To make them comparable, the XSHC.L values have been converted to USD using the latest available exchange rates.

Returns By Period

In the year-to-date period, GNOM.L achieves a 22.10% return, which is significantly higher than XSHC.L's 2.66% return.

GNOM.L

• 1D: -0.17%
• 1M: 11.69%
• 6M: 15.71%
• YTD: 22.10%
• 1Y: 62.79%
• 3Y*: 4.58%
• 5Y*: —
• 10Y*: —

XSHC.L

• 1D: 0.84%
• 1M: 4.76%
• 6M: 1.94%
• YTD: 2.66%
• 1Y: 21.07%
• 3Y*: 8.11%
• 5Y*: 5.47%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

GNOM.L vs. XSHC.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
GNOM.L Global X Genomics & Biotechnology UCITS ETF	22.10%	19.30%	-17.99%	-5.77%	-37.21%	-8.59%
XSHC.L Xtrackers MSCI USA Health Care UCITS ETF 1D	2.66%	14.90%	2.35%	1.51%	-3.42%	5.75%

Correlation

The correlation between GNOM.L and XSHC.L is 0.47, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.47
Correlation (3Y) Calculated over the trailing 3-year period	0.45
Correlation (All Time) Calculated using the full available price history since Nov 2, 2021	0.47

Return for Risk

GNOM.L vs. XSHC.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

GNOM.L

GNOM.L Risk / Return Rank: 77
GNOM.L Sharpe Ratio Rank: 83
GNOM.L Sortino Ratio Rank: 83
GNOM.L Omega Ratio Rank: 73
GNOM.L Calmar Ratio Rank: 80
GNOM.L Martin Ratio Rank: 64

XSHC.L

XSHC.L Risk / Return Rank: 40
XSHC.L Sharpe Ratio Rank: 44
XSHC.L Sortino Ratio Rank: 47
XSHC.L Omega Ratio Rank: 39
XSHC.L Calmar Ratio Rank: 38
XSHC.L Martin Ratio Rank: 32

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

GNOM.L vs. XSHC.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Global X Genomics & Biotechnology UCITS ETF (GNOM.L) and Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	GNOM.L	XSHC.L	Difference
Sharpe ratio: Return per unit of total volatility	2.12	1.39	+0.73
Sortino ratio: Return per unit of downside risk	2.97	2.14	+0.83
Omega ratio: Gain probability vs. loss probability	1.34	1.24	+0.10
Calmar ratio: Return relative to maximum drawdown	3.35	1.92	+1.43
Martin ratio: Return relative to average drawdown	9.16	4.67	+4.50

GNOM.L vs. XSHC.L - Sharpe Ratio Comparison

The current GNOM.L Sharpe Ratio is 2.12, which is higher than the XSHC.L Sharpe Ratio of 1.39. The chart below compares the historical Sharpe Ratios of GNOM.L and XSHC.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

GNOM.L vs. XSHC.L - Drawdown Comparison

The maximum GNOM.L drawdown since its inception was -69.32%, which is greater than XSHC.L's maximum drawdown of -26.83%. Use the drawdown chart below to compare losses from any high point for GNOM.L and XSHC.L.

Drawdown Indicators

	GNOM.L	XSHC.L	Difference
Max Drawdown Largest peak-to-trough decline	-69.32%	-26.83%	-42.49%
Max Drawdown (1Y) Largest decline over 1 year	-18.91%	-10.92%	-7.99%
Max Drawdown (3Y) Largest decline over 3 years	-44.77%	-17.41%	-27.36%
Max Drawdown (5Y) Largest decline over 5 years	—	-17.41%	—
Current Drawdown Current decline from peak	-37.11%	-3.05%	-34.06%
Average Drawdown Average peak-to-trough decline	-47.16%	-4.97%	-42.19%
Ulcer Index Depth and duration of drawdowns from previous peaks	6.92%	4.50%	+2.42%

Volatility

GNOM.L vs. XSHC.L - Volatility Comparison

Global X Genomics & Biotechnology UCITS ETF (GNOM.L) has a higher volatility of 8.41% compared to Xtrackers MSCI USA Health Care UCITS ETF 1D (XSHC.L) at 5.52%. This indicates that GNOM.L's price experiences larger fluctuations and is considered to be riskier than XSHC.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	GNOM.L	XSHC.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	8.41%	5.52%	+2.89%
Volatility (6M) Calculated over the trailing 6-month period	22.18%	11.34%	+10.84%
Volatility (1Y) Calculated over the trailing 1-year period	29.87%	15.15%	+14.72%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	33.11%	14.86%	+18.25%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	33.11%	16.28%	+16.83%

GNOM.L vs. XSHC.L - Expense Ratio Comparison

GNOM.L has a 0.50% expense ratio, which is higher than XSHC.L's 0.12% expense ratio.

Dividends

GNOM.L vs. XSHC.L - Dividend Comparison

GNOM.L has not paid dividends to shareholders, while XSHC.L's dividend yield for the trailing twelve months is around 1.23%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019
GNOM.L Global X Genomics & Biotechnology UCITS ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
XSHC.L Xtrackers MSCI USA Health Care UCITS ETF 1D	1.23%	1.25%	1.24%	1.23%	1.55%	0.85%	1.12%	0.98%

Frequently Asked Questions

Can I hold both GNOM.L and XSHC.L in my portfolio?

GNOM.L and XSHC.L have a correlation of 0.47, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, GNOM.L or XSHC.L?

On fees, XSHC.L is cheaper at 0.12% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, GNOM.L or XSHC.L?

XSHC.L is cheaper with a 0.12% expense ratio, compared with 0.50% for GNOM.L.

What is the main difference between GNOM.L and XSHC.L?

GNOM.L tracks Global X Genomics & Biotechnology UCITS ETF, while XSHC.L tracks MSCI World/Health Care NR USD. They also come from different issuers: Global X and Xtrackers. Their fees differ too: 0.50% for GNOM.L and 0.12% for XSHC.L.