DSGN vs. COHR

Last updated Aug 1, 2026

DSGN (Design Therapeutics, Inc.) and COHR (Coherent Corp.) are both stocks. DSGN operates in Biotechnology (Healthcare), while COHR operates in Scientific & Technical Instruments (Technology). Over the past 5 years, DSGN returned -4.68%/yr vs 30.37%/yr for COHR. Their 0.23 correlation means their historical movements had little consistent relationship.

Performance

DSGN vs. COHR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Design Therapeutics, Inc. (DSGN) and Coherent Corp. (COHR). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, DSGN achieves a 29.85% return, which is significantly lower than COHR's 42.43% return.

DSGN

• 1D: -3.49%
• 1M: -22.12%
• 6M: 19.29%
• YTD: 29.85%
• 1Y: 218.85%
• 3Y*: 16.52%
• 5Y*: -4.68%
• 10Y*: —
• ALL TIME*: -14.42%

COHR

• 1D: 5.55%
• 1M: -21.14%
• 6M: 23.90%
• YTD: 42.43%
• 1Y: 155.75%
• 3Y*: 77.59%
• 5Y*: 30.37%
• 10Y*: 28.55%
• ALL TIME*: 19.25%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
COHR Coherent Corp.	$1.31B	$1.37B	$2.05B
DSGN Design Therapeutics, Inc.	$5.61M	$9.03M	$11.72M

DSGN vs. COHR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
DSGN Design Therapeutics, Inc.	29.85%	52.03%	132.83%	-74.17%	-52.08%	-23.54%
COHR Coherent Corp.	42.43%	94.84%	117.62%	24.02%	-48.63%	2.38%

Correlation

The correlation between DSGN and COHR is 0.18, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.18
Correlation (3Y) Balances recent behavior with more history.	0.21
Correlation (5Y) Shows whether the relationship held over a longer period.	0.23
Correlation (All Time) Calculated using the full available price history since Mar 26, 2021	0.23

Fundamentals

Market Cap DSGN : $760.73M COHR : $51.43B
EPS DSGN : -$1.19 COHR : $1.85K
Total Revenue (TTM) DSGN : $0.00 COHR : $1.81T
Gross Profit (TTM) DSGN : $0.00 COHR : $1.76B
EBITDA (TTM) DSGN : -$73.49M COHR : $960.76M

Return for Risk

DSGN vs. COHR — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

DSGN

DSGN Risk / Return Rank: 94
DSGN Sharpe Ratio Rank: 96
DSGN Sortino Ratio Rank: 92
DSGN Omega Ratio Rank: 91
DSGN Calmar Ratio Rank: 97
DSGN Martin Ratio Rank: 96

COHR

COHR Risk / Return Rank: 87
COHR Sharpe Ratio Rank: 89
COHR Sortino Ratio Rank: 84
COHR Omega Ratio Rank: 84
COHR Calmar Ratio Rank: 87
COHR Martin Ratio Rank: 92

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

DSGN vs. COHR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Design Therapeutics, Inc. (DSGN) and Coherent Corp. (COHR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	DSGN	COHR	Difference
Sharpe ratio: Return per unit of total volatility	2.65	1.79	+0.86
Sortino ratio: Return per unit of downside risk	2.91	2.26	+0.65
Omega ratio: Gain probability vs. loss probability	1.38	1.29	+0.09
Calmar ratio: Return relative to maximum drawdown	6.07	3.03	+3.05
Martin ratio: Return relative to average drawdown	16.35	10.76	+5.59

DSGN vs. COHR - Sharpe Ratio Comparison

The current DSGN Sharpe Ratio is 2.65, which is higher than the COHR Sharpe Ratio of 1.79. The chart below compares the historical Sharpe Ratios of DSGN and COHR, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

DSGN vs. COHR - Drawdown Comparison

The maximum DSGN drawdown since its inception was -95.20%, which is greater than COHR's maximum drawdown of -80.89%. Use the drawdown chart below to compare losses from any high point for DSGN and COHR.

Drawdown Indicators

	DSGN	COHR	Difference
Max Drawdown Largest peak-to-trough decline	-95.20%	-80.89%	-14.31%
Max Drawdown (1Y) Largest decline over 1 year	-35.59%	-47.98%	+12.39%
Max Drawdown (3Y) Largest decline over 3 years	-74.09%	-54.85%	-19.24%
Max Drawdown (5Y) Largest decline over 5 years	-92.22%	-62.87%	-29.35%
Max Drawdown (10Y) Largest decline over 10 years	—	-72.22%	—
Current Drawdown Current decline from peak	-70.64%	-38.42%	-32.22%
Average Drawdown Average peak-to-trough decline	-76.34%	-34.97%	-41.37%
Ulcer Index Depth and duration of drawdowns from previous peaks	13.19%	13.46%	-0.27%

Volatility

DSGN vs. COHR - Volatility Comparison

The current volatility for Design Therapeutics, Inc. (DSGN) is 17.45%, while Coherent Corp. (COHR) has a volatility of 29.28%. This indicates that DSGN experiences smaller price fluctuations and is considered to be less risky than COHR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	DSGN	COHR	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.45%	29.28%	-11.83%
Volatility (6M) Calculated over the trailing 6-month period	55.10%	64.16%	-9.06%
Volatility (1Y) Calculated over the trailing 1-year period	81.59%	81.08%	+0.51%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	85.87%	63.47%	+22.40%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	87.78%	57.61%	+30.17%

Dividends

DSGN vs. COHR - Dividend Comparison

Neither DSGN nor COHR has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both DSGN and COHR in my portfolio?

DSGN and COHR have a correlation of 0.18, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, DSGN or COHR?

COHR has higher volatility (29.28%) compared to DSGN (17.45%). In terms of maximum drawdown, DSGN dropped -95.20% vs COHR's -80.89%.

Which has better risk-adjusted returns?

DSGN currently has the higher Sharpe Ratio (2.65 vs 1.79), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.