DES2.L vs. BIOT.L

Last updated Jul 16, 2026

DES2.L (L&G DAX Daily 2x Short UCITS ETF EUR (Acc)) and BIOT.L (L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF) are both exchange-traded funds - DES2.L is a Inverse Equities fund tracking the ShortDAX x2 Index Gross TR EUR, while BIOT.L is a Health & Biotech Equities fund tracking the Solactive Pharma Breakthrough Value Index Net Total Return. Both are passively managed. Over the past 5 years, DES2.L returned -20.32%/yr vs 3.36%/yr for BIOT.L. At a correlation of -0.47, they often move in opposite directions. DES2.L charges 0.60%/yr vs 0.49%/yr for BIOT.L.

Performance

DES2.L vs. BIOT.L - Performance Comparison

The chart below illustrates the hypothetical performance of a €10,000 investment in L&G DAX Daily 2x Short UCITS ETF EUR (Acc) (DES2.L) and L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

DES2.L is traded in EUR, while BIOT.L is traded in USD. To make them comparable, the BIOT.L values have been converted to EUR using the latest available exchange rates.

Returns By Period

In the year-to-date period, DES2.L achieves a -5.68% return, which is significantly lower than BIOT.L's 10.52% return.

DES2.L

• 1D: 0.93%
• 1M: -0.95%
• 6M: -0.56%
• YTD: -5.68%
• 1Y: -9.69%
• 3Y*: -24.55%
• 5Y*: -20.32%
• 10Y*: -23.54%

BIOT.L

• 1D: 0.00%
• 1M: 8.56%
• 6M: 8.84%
• YTD: 10.52%
• 1Y: 34.89%
• 3Y*: 9.33%
• 5Y*: 3.36%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

DES2.L vs. BIOT.L - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018
DES2.L L&G DAX Daily 2x Short UCITS ETF EUR (Acc)	-5.68%	-36.17%	-25.21%	-28.29%	7.83%	-31.54%	-35.25%	-38.99%	37.96%
BIOT.L L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF	10.52%	20.28%	0.94%	-12.00%	-2.74%	3.61%	17.72%	15.58%	-1.92%

Correlation

The correlation between DES2.L and BIOT.L is -0.40, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.40
Correlation (3Y) Calculated over the trailing 3-year period	-0.42
Correlation (5Y) Calculated over the trailing 5-year period	-0.44
Correlation (All Time) Calculated using the full available price history since Jan 18, 2018	-0.47

Return for Risk

DES2.L vs. BIOT.L — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

DES2.L

DES2.L Risk / Return Rank: 6
DES2.L Sharpe Ratio Rank: 6
DES2.L Sortino Ratio Rank: 7
DES2.L Omega Ratio Rank: 7
DES2.L Calmar Ratio Rank: 6
DES2.L Martin Ratio Rank: 5

BIOT.L

BIOT.L Risk / Return Rank: 67
BIOT.L Sharpe Ratio Rank: 63
BIOT.L Sortino Ratio Rank: 64
BIOT.L Omega Ratio Rank: 55
BIOT.L Calmar Ratio Rank: 83
BIOT.L Martin Ratio Rank: 70

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

DES2.L vs. BIOT.L - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for L&G DAX Daily 2x Short UCITS ETF EUR (Acc) (DES2.L) and L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	DES2.L	BIOT.L	Difference
Sharpe ratio: Return per unit of total volatility	-0.30	1.73	-2.04
Sortino ratio: Return per unit of downside risk	-0.22	2.47	-2.70
Omega ratio: Gain probability vs. loss probability	0.97	1.29	-0.32
Calmar ratio: Return relative to maximum drawdown	-0.37	3.75	-4.13
Martin ratio: Return relative to average drawdown	-0.80	11.01	-11.81

DES2.L vs. BIOT.L - Sharpe Ratio Comparison

The current DES2.L Sharpe Ratio is -0.30, which is lower than the BIOT.L Sharpe Ratio of 1.73. The chart below compares the historical Sharpe Ratios of DES2.L and BIOT.L, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

DES2.L vs. BIOT.L - Drawdown Comparison

The maximum DES2.L drawdown since its inception was -99.57%, which is greater than BIOT.L's maximum drawdown of -30.08%. Use the drawdown chart below to compare losses from any high point for DES2.L and BIOT.L.

Drawdown Indicators

	DES2.L	BIOT.L	Difference
Max Drawdown Largest peak-to-trough decline	-99.57%	-30.08%	-69.49%
Max Drawdown (1Y) Largest decline over 1 year	-25.84%	-9.37%	-16.47%
Max Drawdown (3Y) Largest decline over 3 years	-66.96%	-22.16%	-44.80%
Max Drawdown (5Y) Largest decline over 5 years	-78.04%	-30.08%	-47.96%
Max Drawdown (10Y) Largest decline over 10 years	-93.66%	—	—
Current Drawdown Current decline from peak	-99.55%	-6.35%	-93.20%
Average Drawdown Average peak-to-trough decline	-87.79%	-9.93%	-77.86%
Ulcer Index Depth and duration of drawdowns from previous peaks	12.11%	3.20%	+8.91%

Volatility

DES2.L vs. BIOT.L - Volatility Comparison

L&G DAX Daily 2x Short UCITS ETF EUR (Acc) (DES2.L) has a higher volatility of 9.28% compared to L&G Pharma Breakthrough UCITS ETF - USD Accumulating ETF (BIOT.L) at 6.18%. This indicates that DES2.L's price experiences larger fluctuations and is considered to be riskier than BIOT.L based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	DES2.L	BIOT.L	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.28%	6.18%	+3.10%
Volatility (6M) Calculated over the trailing 6-month period	26.99%	14.92%	+12.07%
Volatility (1Y) Calculated over the trailing 1-year period	32.03%	20.28%	+11.75%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	34.22%	18.14%	+16.08%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	36.12%	19.32%	+16.80%

DES2.L vs. BIOT.L - Expense Ratio Comparison

DES2.L has a 0.60% expense ratio, which is higher than BIOT.L's 0.49% expense ratio.

Dividends

DES2.L vs. BIOT.L - Dividend Comparison

Neither DES2.L nor BIOT.L has paid dividends to shareholders.

Tickers have no history of dividend payments

Frequently Asked Questions

Can I hold both DES2.L and BIOT.L in my portfolio?

DES2.L and BIOT.L have a correlation of -0.40, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which ETF is better, DES2.L or BIOT.L?

On fees, BIOT.L is cheaper at 0.49% per year. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF is cheaper, DES2.L or BIOT.L?

BIOT.L is cheaper with a 0.49% expense ratio, compared with 0.60% for DES2.L.

What is the main difference between DES2.L and BIOT.L?

DES2.L is categorized as Inverse Equities, while BIOT.L is Health & Biotech Equities. DES2.L tracks ShortDAX x2 Index Gross TR EUR, while BIOT.L tracks Solactive Pharma Breakthrough Value Index Net Total Return. Their fees differ too: 0.60% for DES2.L and 0.49% for BIOT.L.