CELZ vs. GAIN

Last updated Jul 11, 2026

CELZ (Creative Medical Technology Holdings Inc) and GAIN (Gladstone Investment Corporation) are both stocks. CELZ operates in Biotechnology (Healthcare), while GAIN operates in Asset Management (Financial Services). Over the past 10 years, CELZ returned -71.38%/yr vs 19.49%/yr for GAIN. At a 0.07 correlation, their price movements are largely independent.

Performance

CELZ vs. GAIN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Creative Medical Technology Holdings Inc (CELZ) and Gladstone Investment Corporation (GAIN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, CELZ achieves a -53.46% return, which is significantly lower than GAIN's 21.73% return. Over the past 10 years, CELZ has underperformed GAIN with an annualized return of -71.38%, while GAIN has yielded a comparatively higher 19.49% annualized return.

CELZ

• 1D: -3.10%
• 1M: -57.97%
• 6M: -59.46%
• YTD: -53.46%
• 1Y: -68.66%
• 3Y*: -42.94%
• 5Y*: -64.38%
• 10Y*: -71.38%

GAIN

• 1D: 0.67%
• 1M: 7.68%
• 6M: 22.08%
• YTD: 21.73%
• 1Y: 24.82%
• 3Y*: 21.38%
• 5Y*: 14.54%
• 10Y*: 19.49%

*Multi-year figures are annualized to reflect compound growth (CAGR)

CELZ vs. GAIN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
CELZ Creative Medical Technology Holdings Inc	-53.46%	-15.15%	-49.89%	20.97%	-82.76%	-84.10%	-38.22%	-96.96%	-26.81%	-97.35%
GAIN Gladstone Investment Corporation	21.73%	17.11%	5.33%	31.01%	-17.55%	82.14%	-16.56%	53.31%	-9.67%	44.63%

Correlation

The correlation between CELZ and GAIN is 0.15, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.15
Correlation (3Y) Calculated over the trailing 3-year period	0.10
Correlation (5Y) Calculated over the trailing 5-year period	0.13
Correlation (10Y) Calculated over the trailing 10-year period	0.08
Correlation (All Time) Calculated using the full available price history since Nov 6, 2015	0.07

Fundamentals

Market Cap CELZ : $2.35M GAIN : $655.47M
EPS CELZ : -$1.99 GAIN : $3.34
PS Ratio CELZ : 878.15 GAIN : 5.71
Total Revenue (TTM) CELZ : $3.00K GAIN : $112.66M
Gross Profit (TTM) CELZ : -$59.69K GAIN : $80.66M
EBITDA (TTM) CELZ : -$4.39M GAIN : $57.95M

Return for Risk

CELZ vs. GAIN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CELZ

CELZ Risk / Return Rank: 18
CELZ Sharpe Ratio Rank: 20
CELZ Sortino Ratio Rank: 23
CELZ Omega Ratio Rank: 20
CELZ Calmar Ratio Rank: 13
CELZ Martin Ratio Rank: 12

GAIN

GAIN Risk / Return Rank: 79
GAIN Sharpe Ratio Rank: 81
GAIN Sortino Ratio Rank: 76
GAIN Omega Ratio Rank: 77
GAIN Calmar Ratio Rank: 78
GAIN Martin Ratio Rank: 83

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CELZ vs. GAIN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Creative Medical Technology Holdings Inc (CELZ) and Gladstone Investment Corporation (GAIN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	CELZ	GAIN	Difference
Sharpe ratio: Return per unit of total volatility	-0.55	1.25	-1.80
Sortino ratio: Return per unit of downside risk	-0.50	1.82	-2.32
Omega ratio: Gain probability vs. loss probability	0.92	1.24	-0.32
Calmar ratio: Return relative to maximum drawdown	-0.80	1.94	-2.73
Martin ratio: Return relative to average drawdown	-1.32	6.39	-7.70

CELZ vs. GAIN - Sharpe Ratio Comparison

The current CELZ Sharpe Ratio is -0.55, which is lower than the GAIN Sharpe Ratio of 1.25. The chart below compares the historical Sharpe Ratios of CELZ and GAIN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

CELZ vs. GAIN - Drawdown Comparison

The maximum CELZ drawdown since its inception was -100.00%, which is greater than GAIN's maximum drawdown of -80.87%. Use the drawdown chart below to compare losses from any high point for CELZ and GAIN.

Drawdown Indicators

	CELZ	GAIN	Difference
Max Drawdown Largest peak-to-trough decline	-100.00%	-80.87%	-19.13%
Max Drawdown (1Y) Largest decline over 1 year	-85.51%	-12.75%	-72.76%
Max Drawdown (3Y) Largest decline over 3 years	-87.78%	-14.76%	-73.02%
Max Drawdown (5Y) Largest decline over 5 years	-99.54%	-26.26%	-73.28%
Max Drawdown (10Y) Largest decline over 10 years	-100.00%	-56.28%	-43.72%
Current Drawdown Current decline from peak	-100.00%	-2.17%	-97.83%
Average Drawdown Average peak-to-trough decline	-85.78%	-15.88%	-69.90%
Ulcer Index Depth and duration of drawdowns from previous peaks	51.89%	3.85%	+48.04%

Volatility

CELZ vs. GAIN - Volatility Comparison

Creative Medical Technology Holdings Inc (CELZ) has a higher volatility of 91.18% compared to Gladstone Investment Corporation (GAIN) at 6.17%. This indicates that CELZ's price experiences larger fluctuations and is considered to be riskier than GAIN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CELZ	GAIN	Difference
Volatility (1M) Calculated over the trailing 1-month period	91.18%	6.17%	+85.01%
Volatility (6M) Calculated over the trailing 6-month period	99.42%	17.24%	+82.18%
Volatility (1Y) Calculated over the trailing 1-year period	128.04%	19.67%	+108.37%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	137.13%	22.39%	+114.74%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	307.23%	25.76%	+281.47%

Dividends

CELZ vs. GAIN - Dividend Comparison

CELZ has not paid dividends to shareholders, while GAIN's dividend yield for the trailing twelve months is around 5.83%.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
CELZ Creative Medical Technology Holdings Inc	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
GAIN Gladstone Investment Corporation	5.83%	10.74%	12.53%	17.24%	9.88%	6.06%	9.22%	7.06%	9.24%	7.94%	8.87%	9.68%

Financials

Frequently Asked Questions

Can I hold both CELZ and GAIN in my portfolio?

CELZ and GAIN have a correlation of 0.15, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CELZ or GAIN?

CELZ has higher volatility (91.18%) compared to GAIN (6.17%). In terms of maximum drawdown, CELZ dropped -100.00% vs GAIN's -80.87%.

Which has better risk-adjusted returns?

GAIN currently has the higher Sharpe Ratio (1.25 vs -0.55), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.