Werewolf Therapeutics, Inc. (HOWL)

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The chart shows the growth of an initial investment of $10,000 in Werewolf Therapeutics, Inc., comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends.

Werewolf Therapeutics, Inc. (HOWL) has returned 31.43% so far this year and -14.36% over the past 12 months.

Based on dividend-adjusted daily data since Apr 30, 2021, HOWL's average daily return is -0.04%, while the average monthly return is -1.83%.

Historically, 36% of months were positive and 64% were negative. The best month was Jan 2023 with a return of +95.1%, while the worst month was Jun 2024 at -52.8%. The longest winning streak lasted 3 consecutive months, and the longest losing streak was 7 months.

On a daily basis, HOWL closed higher 43% of trading days. The best single day was Nov 3, 2023 with a return of +47.4%, while the worst single day was Dec 18, 2025 at -39.6%.

Werewolf Therapeutics, Inc. has an annualized alpha of -21.72%, beta of 1.44, and R² of 0.06 versus S&P 500 Index. Calculated based on daily prices since May 03, 2021.

• This stock participated in 155.70% of S&P 500 Index downside but only -67.29% of its upside — more exposed to losses than it benefited from rallies.
• R² of 0.06 means this stock moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

HOWL ranks 37 for risk / return — below 37% of stocks on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.

The table below present risk-adjusted performance metrics for Werewolf Therapeutics, Inc. (HOWL) and compare them to a chosen benchmark (S&P 500 Index).

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.

The table below displays the maximum drawdowns of the Werewolf Therapeutics, Inc.. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the Werewolf Therapeutics, Inc. was 97.30%, occurring on Jan 16, 2026. The portfolio has not yet recovered.

The current Werewolf Therapeutics, Inc. drawdown is 95.90%.

The chart below shows the rolling one-month volatility.

The chart below illustrates the trends in the financial health of Werewolf Therapeutics, Inc. over time, highlighting three key metrics: Total Revenue, Earnings Before Interest and Taxes (EBIT), and Net Income.

The Valuation section provides an overview of how Werewolf Therapeutics, Inc. is priced in the market compared to other companies in the Biotechnology industry. It includes key financial ratios that help investors assess whether the stock is undervalued or overvalued.