HOWL vs. RANI

Last updated Apr 1, 2026

Compare and contrast key facts about Werewolf Therapeutics, Inc. (HOWL) and Rani Therapeutics Holdings, Inc. (RANI).

Performance

HOWL vs. RANI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Werewolf Therapeutics, Inc. (HOWL) and Rani Therapeutics Holdings, Inc. (RANI). The values are adjusted to include any dividend payments, if applicable.

HOWL vs. RANI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
HOWL Werewolf Therapeutics, Inc.	31.43%	-57.20%	-61.66%	88.29%	-82.79%	-31.63%
RANI Rani Therapeutics Holdings, Inc.	-45.57%	-1.46%	-58.73%	-43.73%	-63.91%	48.64%

Fundamentals

Market Cap HOWL : $38.97M RANI : $108.08M
EPS HOWL : -$1.33 RANI : -$0.40
PB Ratio HOWL : 1.57 RANI : 3.27
Total Revenue (TTM) HOWL : $0.00 RANI : $172.00K
Gross Profit (TTM) HOWL : -$832.00K RANI : -$51.00K
EBITDA (TTM) HOWL : -$48.00M RANI : -$37.15M

Returns By Period

In the year-to-date period, HOWL achieves a 31.43% return, which is significantly higher than RANI's -45.57% return.

HOWL

• 1D: 4.48%
• 1M: 38.72%
• YTD: 31.43%
• 6M: -57.74%
• 1Y: -14.36%
• 3Y*: -31.58%
• 5Y*: —
• 10Y*: —

RANI

• 1D: -3.71%
• 1M: -46.36%
• YTD: -45.57%
• 6M: 47.02%
• 1Y: -41.68%
• 3Y*: -47.78%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

HOWL vs. RANI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

HOWL

HOWL Risk / Return Rank: 37
HOWL Sharpe Ratio Rank: 34
HOWL Sortino Ratio Rank: 44
HOWL Omega Ratio Rank: 42
HOWL Calmar Ratio Rank: 33
HOWL Martin Ratio Rank: 34

RANI

RANI Risk / Return Rank: 45
RANI Sharpe Ratio Rank: 34
RANI Sortino Ratio Rank: 73
RANI Omega Ratio Rank: 71
RANI Calmar Ratio Rank: 20
RANI Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

HOWL vs. RANI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Werewolf Therapeutics, Inc. (HOWL) and Rani Therapeutics Holdings, Inc. (RANI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	HOWL	RANI	Difference
Sharpe ratio Return per unit of total volatility	-0.14	-0.15	+0.01
Sortino ratio Return per unit of downside risk	0.55	1.75	-1.20
Omega ratio Gain probability vs. loss probability	1.07	1.22	-0.15
Calmar ratio Return relative to maximum drawdown	-0.26	-0.62	+0.36
Martin ratio Return relative to average drawdown	-0.45	-0.87	+0.42
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

HOWL vs. RANI - Sharpe Ratio Comparison

The current HOWL Sharpe Ratio is -0.14, which is comparable to the RANI Sharpe Ratio of -0.15. The chart below compares the historical Sharpe Ratios of HOWL and RANI, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	HOWL	RANI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.14	-0.15	+0.01
Sharpe Ratio (All Time) Calculated using the full available price history	-0.44	-0.28	-0.16

Correlation

The correlation between HOWL and RANI is 0.16, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

HOWL vs. RANI - Dividend Comparison

Neither HOWL nor RANI has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

HOWL vs. RANI - Drawdown Comparison

The maximum HOWL drawdown since its inception was -97.30%, roughly equal to the maximum RANI drawdown of -98.83%. Use the drawdown chart below to compare losses from any high point for HOWL and RANI.

Drawdown Indicators

	HOWL	RANI	Difference
Max Drawdown Largest peak-to-trough decline	-97.30%	-98.83%	+1.53%
Max Drawdown (1Y) Largest decline over 1 year	-74.92%	-74.22%	-0.70%
Current Drawdown Current decline from peak	-95.90%	-97.90%	+2.00%
Average Drawdown Average peak-to-trough decline	-76.14%	-79.90%	+3.76%
Ulcer Index Depth and duration of drawdowns from previous peaks	42.68%	52.90%	-10.22%

Volatility

HOWL vs. RANI - Volatility Comparison

The current volatility for Werewolf Therapeutics, Inc. (HOWL) is 28.40%, while Rani Therapeutics Holdings, Inc. (RANI) has a volatility of 33.24%. This indicates that HOWL experiences smaller price fluctuations and is considered to be less risky than RANI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	HOWL	RANI	Difference
Volatility (1M) Calculated over the trailing 1-month period	28.40%	33.24%	-4.84%
Volatility (6M) Calculated over the trailing 6-month period	78.82%	153.01%	-74.19%
Volatility (1Y) Calculated over the trailing 1-year period	102.03%	277.14%	-175.11%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	102.55%	157.68%	-55.13%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	102.55%	157.68%	-55.13%

Financials