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biotech
Performance
Return for Risk
Dividends
Drawdowns
Volatility
Diversification

Asset Allocation


EXEL 16.67%SUPN 16.67%DFTX 16.67%ALNY 16.67%CORT 16.67%BMRN 16.67%EquityEquity

S&P 500 Index

Performance

Performance Chart

The chart shows the growth of an initial investment of $10,000 in biotech , comparing it to the performance of the S&P 500 index or another benchmark. All prices have been adjusted for splits and dividends. The portfolio is rebalanced Every 3 months.


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The earliest data available for this chart is Jul 11, 2022, corresponding to the inception date of DFTX

Returns By Period


1D1MYTD6M1Y3Y*5Y*10Y*
Benchmark
S&P 500 Index
0.80%4.83%2.59%5.27%30.14%19.29%10.91%12.94%
Portfolio
biotech
-0.69%8.60%9.75%1.20%47.50%34.47%
EXEL
Exelixis, Inc.
-3.45%7.82%1.03%10.62%21.18%31.53%13.42%26.12%
SUPN
Supernus Pharmaceuticals, Inc.
-0.34%-0.54%0.48%1.36%58.74%11.47%9.52%11.83%
DFTX
Definium Therapeutics, Inc
1.00%20.91%65.42%74.96%295.54%91.38%
ALNY
Alnylam Pharmaceuticals, Inc.
-1.77%4.54%-16.16%-29.11%44.37%17.81%19.14%17.10%
CORT
Corcept Therapeutics Incorporated
0.50%36.42%26.15%-42.85%-36.92%25.57%14.04%24.52%
BMRN
BioMarin Pharmaceutical Inc.
-0.36%-3.76%-7.00%4.11%-7.91%-17.66%-6.99%-4.41%
*Multi-year figures are annualized to reflect compound growth (CAGR)

Monthly Returns

Based on dividend-adjusted daily data since Jul 12, 2022, biotech 's average daily return is +0.11%, while the average monthly return is +2.27%. At this rate, an investment would double in approximately 2.6 years.

Historically, 57% of months were positive and 43% were negative. The best month was Mar 2024 with a return of +21.5%, while the worst month was Sep 2022 at -15.9%. The longest winning streak lasted 4 consecutive months, and the longest losing streak was 2 months.

On a daily basis, biotech closed higher 52% of trading days. The best single day was Mar 31, 2025 with a return of +17.5%, while the worst single day was Apr 1, 2025 at -8.5%.


JanFebMarAprMayJunJulAugSepOctNovDecTotal
20261.01%4.52%-0.23%4.19%9.75%
20257.86%-1.96%14.70%-10.76%6.38%-2.15%8.37%8.09%10.94%2.72%-1.46%-8.77%35.21%
2024-10.32%9.56%21.46%-5.07%-0.05%11.38%10.63%-0.74%-1.31%7.38%10.45%-8.01%49.12%
202316.35%-5.62%-1.27%3.14%-4.21%-2.07%10.55%5.10%-11.24%-9.76%10.10%11.82%20.20%
20223.49%6.78%-15.88%1.26%1.60%-4.76%-8.92%

Benchmark Metrics

biotech has an annualized alpha of 13.72%, beta of 0.88, and R² of 0.23 versus S&P 500 Index. Calculated based on daily prices since July 12, 2022.

  • This portfolio captured 127.81% of S&P 500 Index gains but only 93.49% of its losses — a favorable profile for investors.
  • R² of 0.23 means this portfolio moves largely independently of S&P 500 Index — capture ratios reflect limited market correlation rather than active downside protection. Consider using a more representative benchmark.

Alpha
13.72%
Beta
0.88
0.23
Upside Capture
127.81%
Downside Capture
93.49%

Expense Ratio

biotech has an expense ratio of 0.00%, meaning no management fees are charged. Below, you can find the expense ratios of the portfolio's funds side by side and easily compare their relative costs.


The portfolio doesn't include any funds that charge management fees.

Return for Risk

Risk / Return Rank

biotech ranks 22 for risk / return — below 22% of portfolios on our site. The returns aren't fully compensating for the risk involved. This isn't necessarily a dealbreaker, but factor it into your decision — especially if you're risk-averse.


biotech Risk / Return Rank: 2222
Overall Rank
biotech Sharpe Ratio Rank: 1616
Sharpe Ratio Rank
biotech Sortino Ratio Rank: 1616
Sortino Ratio Rank
biotech Omega Ratio Rank: 1616
Omega Ratio Rank
biotech Calmar Ratio Rank: 4343
Calmar Ratio Rank
biotech Martin Ratio Rank: 2121
Martin Ratio Rank
The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

Return / Risk — by metrics


PortfolioBenchmarkDifference

Sharpe ratio

Return per unit of total volatility

1.77

2.30

-0.53

Sortino ratio

Return per unit of downside risk

2.38

3.18

-0.80

Omega ratio

Gain probability vs. loss probability

1.31

1.43

-0.12

Calmar ratio

Return relative to maximum drawdown

3.57

3.40

+0.16

Martin ratio

Return relative to average drawdown

8.27

15.35

-7.09


How much return does each position deliver for the risk it carries? Higher values mean better reward for the risk taken.

Risk / Return RankSharpe ratioSortino ratioOmega ratioCalmar ratioMartin ratio
EXEL
Exelixis, Inc.
490.490.991.151.002.34
SUPN
Supernus Pharmaceuticals, Inc.
741.692.171.342.556.10
DFTX
Definium Therapeutics, Inc
964.804.331.5212.4238.20
ALNY
Alnylam Pharmaceuticals, Inc.
591.181.851.231.072.26
CORT
Corcept Therapeutics Incorporated
16-0.49-0.170.97-0.56-1.12
BMRN
BioMarin Pharmaceutical Inc.
24-0.25-0.170.98-0.14-0.24

Sharpe Ratio

The Sharpe ratio helps investors understand how much return they're getting for the level of risk taken. A higher Sharpe ratio indicates better risk-adjusted performance, meaning more reward for each unit of risk.

biotech Sharpe ratios as of Apr 16, 2026 (values are recalculated daily):

  • 1-Year: 1.77
  • All Time: 0.88

These values reflect how efficiently the investment has delivered returns relative to its volatility over different time periods. All figures are annualized and based on daily total returns (including price changes and dividends).

Compared to the broad market, where average Sharpe ratios range from 2.20 to 3.00, this portfolio's current Sharpe ratio places it in the bottom 25%. This suggests weaker risk-adjusted returns than most portfolios, possibly due to lower returns, higher volatility, or both. It may be worth reviewing the allocation. You can use the Portfolio Optimization tool to explore options for improving the Sharpe ratio.

The chart below shows the rolling Sharpe ratio of biotech compared to the selected benchmark. This view highlights how the investment's risk-adjusted performance has changed over time.


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Dividends

Dividend yield


biotech doesn't pay dividends

Drawdowns

Drawdowns Chart

The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.


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Worst Drawdowns

The table below displays the maximum drawdowns of the biotech . A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.

The maximum drawdown for the biotech was 28.62%, occurring on Nov 9, 2022. Recovery took 331 trading sessions.

The current biotech drawdown is 4.77%.


Depth

Start

To Bottom

Bottom

To Recover

End

Total

-28.62%Aug 19, 202258Nov 9, 2022331Mar 7, 2024389
-20.91%Apr 1, 20256Apr 8, 202568Jul 17, 202574
-14.43%Feb 18, 202518Mar 13, 202512Mar 31, 202530
-13.98%Dec 24, 202561Mar 24, 2026
-12.31%Apr 4, 202436May 23, 202422Jun 26, 202458

Volatility

Volatility Chart

The chart below shows the rolling one-month volatility.


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Diversification

Diversification Metrics


Number of Effective Assets

The portfolio contains 6 assets, with an effective number of assets of 6.00, reflecting the diversification based on asset allocation. This number of effective assets indicates a moderate level of diversification, where some assets may have a more significant influence on overall performance.

Asset Correlations Table

The table below displays the correlation coefficients between the individual components of the portfolio, the entire portfolio, and the chosen benchmark.

BenchmarkSUPNDFTXBMRNEXELCORTALNYPortfolio
Benchmark1.000.320.340.320.310.360.360.49
SUPN0.321.000.220.270.300.280.240.50
DFTX0.340.221.000.230.200.250.270.73
BMRN0.320.270.231.000.320.250.350.51
EXEL0.310.300.200.321.000.290.320.52
CORT0.360.280.250.250.291.000.280.58
ALNY0.360.240.270.350.320.281.000.57
Portfolio0.490.500.730.510.520.580.571.00
The correlation results are calculated based on daily price changes starting from Jul 12, 2022