Biotech-2023
Asset Allocation
| Position | Category/Sector | Target Weight |
|---|---|---|
ARWR Arrowhead Pharmaceuticals, Inc. | Healthcare | 20% |
DTIL Precision BioSciences, Inc. | Healthcare | 2% |
ISRG Intuitive Surgical, Inc. | Healthcare | 33% |
MREO Mereo BioPharma Group plc | Healthcare | 9% |
NTLA Intellia Therapeutics, Inc. | Healthcare | 9% |
ONCT Oncternal Therapeutics, Inc. | Healthcare | 4% |
SAGE Sage Therapeutics, Inc. | Healthcare | 14% |
TGTX TG Therapeutics, Inc. | Healthcare | 9% |
Performance
Performance Chart
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The earliest data available for this chart is Apr 24, 2019, corresponding to the inception date of MREO
Returns By Period
| YTD | 1M | 6M | 1Y | 5Y* | 10Y* | |
|---|---|---|---|---|---|---|
^GSPC S&P 500 | -3.77% | 7.44% | -5.60% | 8.37% | 14.12% | 10.46% |
| Biotech-2023 | -4.34% | 10.05% | -15.42% | -10.25% | 6.42% | N/A |
| Portfolio components: | ||||||
ARWR Arrowhead Pharmaceuticals, Inc. | -30.69% | 17.28% | -40.48% | -40.99% | -18.58% | 7.78% |
SAGE Sage Therapeutics, Inc. | 20.81% | -5.07% | 3.96% | -44.87% | -30.19% | -19.53% |
TGTX TG Therapeutics, Inc. | 11.76% | -6.50% | 16.77% | 102.41% | 10.75% | 7.99% |
MREO Mereo BioPharma Group plc | -31.14% | 31.69% | -43.43% | -20.46% | 14.08% | N/A |
ONCT Oncternal Therapeutics, Inc. | 0.00% | 0.00% | -58.54% | -93.56% | -59.89% | -54.23% |
NTLA Intellia Therapeutics, Inc. | -30.36% | 19.94% | -51.46% | -66.80% | -12.27% | N/A |
DTIL Precision BioSciences, Inc. | 34.65% | 21.28% | -38.78% | -51.79% | -53.35% | N/A |
ISRG Intuitive Surgical, Inc. | 2.79% | 9.60% | 0.01% | 38.74% | 24.54% | 25.57% |
Monthly Returns
The table below presents the monthly returns of Biotech-2023, with color gradation from worst to best to easily spot seasonal factors. Returns are adjusted for dividends.
| Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | 7.73% | -2.67% | -10.10% | 7.19% | -5.33% | -4.34% | |||||||
| 2024 | 10.61% | 1.89% | -7.31% | -14.41% | 4.96% | 6.47% | 5.05% | -2.15% | -9.40% | -3.05% | 9.25% | -12.85% | -14.08% |
| 2023 | 5.11% | -5.43% | -5.41% | 27.66% | -2.29% | 6.21% | -6.68% | -16.14% | -6.91% | -3.59% | 11.80% | 18.51% | 15.93% |
| 2022 | -20.37% | -5.23% | -4.34% | -21.44% | -8.77% | 5.43% | 16.26% | -1.95% | -11.54% | 12.56% | 4.68% | 4.97% | -31.96% |
| 2021 | -3.92% | 3.82% | -1.52% | 6.40% | -5.28% | 14.53% | -8.86% | 3.38% | -5.51% | 0.06% | -10.10% | 3.35% | -6.14% |
| 2020 | -15.08% | -8.40% | -17.86% | 15.36% | 8.88% | 23.45% | 5.55% | 7.50% | 0.24% | 7.39% | 16.81% | 28.37% | 81.46% |
| 2019 | -2.71% | -0.81% | 9.50% | -1.59% | 3.81% | -8.59% | 10.15% | 31.77% | -7.06% | 33.10% |
Expense Ratio
Biotech-2023 has an expense ratio of 0.00%, meaning no management fees are charged. Below, you can find the expense ratios of the portfolio's funds side by side and easily compare their relative costs.
Risk-Adjusted Performance
Risk-Adjusted Performance Rank
The current rank of Biotech-2023 is 2, meaning it’s performing worse than 98% of other portfolios on our website when it comes to balancing risk and reward. Below is a breakdown of how it compares using common performance measures.
Risk-Adjusted Performance Indicators
This table presents a comparison of risk-adjusted performance metrics for positions. Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| Sharpe ratio | Sortino ratio | Omega ratio | Calmar ratio | Martin ratio | |
|---|---|---|---|---|---|
ARWR Arrowhead Pharmaceuticals, Inc. | -0.71 | -0.95 | 0.89 | -0.54 | -1.45 |
SAGE Sage Therapeutics, Inc. | -0.65 | -0.85 | 0.89 | -0.51 | -1.20 |
TGTX TG Therapeutics, Inc. | 1.57 | 2.28 | 1.28 | 1.35 | 9.96 |
MREO Mereo BioPharma Group plc | -0.42 | -0.05 | 0.99 | -0.27 | -0.67 |
ONCT Oncternal Therapeutics, Inc. | -0.85 | -2.19 | 0.57 | -0.94 | -1.22 |
NTLA Intellia Therapeutics, Inc. | -0.93 | -1.47 | 0.83 | -0.68 | -1.44 |
DTIL Precision BioSciences, Inc. | -0.70 | -0.89 | 0.90 | -0.52 | -1.12 |
ISRG Intuitive Surgical, Inc. | 1.17 | 1.81 | 1.25 | 1.46 | 4.64 |
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Dividends
Dividend yield
Drawdowns
Drawdowns Chart
The Drawdowns chart displays portfolio losses from any high point along the way. Drawdowns are calculated considering price movements and all distributions paid, if any.
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Worst Drawdowns
The table below displays the maximum drawdowns of the Biotech-2023. A maximum drawdown is a measure of risk, indicating the largest reduction in portfolio value due to a series of losing trades.
The maximum drawdown for the Biotech-2023 was 62.53%, occurring on May 11, 2022. The portfolio has not yet recovered.
The current Biotech-2023 drawdown is 47.33%.
Depth | Start | To Bottom | Bottom | To Recover | End | Total |
|---|---|---|---|---|---|---|
| -62.53% | Jul 2, 2021 | 217 | May 11, 2022 | — | — | — |
| -51.27% | Dec 2, 2019 | 74 | Mar 18, 2020 | 84 | Jul 17, 2020 | 158 |
| -18.21% | Jan 15, 2021 | 35 | Mar 8, 2021 | 67 | Jun 11, 2021 | 102 |
| -15.2% | Aug 22, 2019 | 29 | Oct 2, 2019 | 22 | Nov 1, 2019 | 51 |
| -9.51% | Sep 3, 2020 | 3 | Sep 8, 2020 | 6 | Sep 16, 2020 | 9 |
Volatility
Volatility Chart
The chart below shows the rolling one-month volatility.
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Diversification
Diversification Metrics
Number of Effective Assets
The portfolio contains 8 assets, with an effective number of assets of 5.13, reflecting the diversification based on asset allocation. This number of effective assets indicates a moderate level of diversification, where some assets may have a more significant influence on overall performance.
Asset Correlations Table
| ^GSPC | ONCT | MREO | DTIL | ISRG | SAGE | TGTX | ARWR | NTLA | Portfolio | |
|---|---|---|---|---|---|---|---|---|---|---|
| ^GSPC | 1.00 | 0.20 | 0.24 | 0.33 | 0.72 | 0.38 | 0.43 | 0.44 | 0.48 | 0.62 |
| ONCT | 0.20 | 1.00 | 0.19 | 0.20 | 0.16 | 0.25 | 0.22 | 0.23 | 0.22 | 0.36 |
| MREO | 0.24 | 0.19 | 1.00 | 0.21 | 0.19 | 0.25 | 0.23 | 0.30 | 0.27 | 0.51 |
| DTIL | 0.33 | 0.20 | 0.21 | 1.00 | 0.26 | 0.34 | 0.37 | 0.37 | 0.44 | 0.48 |
| ISRG | 0.72 | 0.16 | 0.19 | 0.26 | 1.00 | 0.31 | 0.38 | 0.37 | 0.40 | 0.62 |
| SAGE | 0.38 | 0.25 | 0.25 | 0.34 | 0.31 | 1.00 | 0.43 | 0.45 | 0.46 | 0.64 |
| TGTX | 0.43 | 0.22 | 0.23 | 0.37 | 0.38 | 0.43 | 1.00 | 0.49 | 0.52 | 0.68 |
| ARWR | 0.44 | 0.23 | 0.30 | 0.37 | 0.37 | 0.45 | 0.49 | 1.00 | 0.56 | 0.78 |
| NTLA | 0.48 | 0.22 | 0.27 | 0.44 | 0.40 | 0.46 | 0.52 | 0.56 | 1.00 | 0.73 |
| Portfolio | 0.62 | 0.36 | 0.51 | 0.48 | 0.62 | 0.64 | 0.68 | 0.78 | 0.73 | 1.00 |