XBI vs. AVXL

Last updated Apr 3, 2026

Compare and contrast key facts about SPDR S&P Biotech ETF (XBI) and Anavex Life Sciences Corp. (AVXL).

XBI is a passively managed fund by State Street that tracks the performance of the S&P Biotechnology Select Industry Index. It was launched on Feb 6, 2006.

Performance

XBI vs. AVXL - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in SPDR S&P Biotech ETF (XBI) and Anavex Life Sciences Corp. (AVXL). The values are adjusted to include any dividend payments, if applicable.

XBI vs. AVXL - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
XBI SPDR S&P Biotech ETF	5.77%	35.89%	1.01%	7.60%	-25.87%	-20.45%	48.33%	32.56%	-15.28%	43.77%
AVXL Anavex Life Sciences Corp.	-16.01%	-66.85%	15.36%	0.54%	-46.60%	221.11%	108.49%	66.03%	-51.55%	-18.69%

Returns By Period

In the year-to-date period, XBI achieves a 5.77% return, which is significantly higher than AVXL's -16.01% return. Over the past 10 years, XBI has outperformed AVXL with an annualized return of 9.28%, while AVXL has yielded a comparatively lower -5.67% annualized return.

XBI

• 1D: 0.32%
• 1M: 4.42%
• YTD: 5.77%
• 6M: 26.12%
• 1Y: 60.61%
• 3Y*: 18.94%
• 5Y*: -1.10%
• 10Y*: 9.28%

AVXL

• 1D: -3.55%
• 1M: -36.25%
• YTD: -16.01%
• 6M: -67.25%
• 1Y: -65.07%
• 3Y*: -29.44%
• 5Y*: -27.93%
• 10Y*: -5.67%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

XBI vs. AVXL — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

XBI

XBI Risk / Return Rank: 92
XBI Sharpe Ratio Rank: 91
XBI Sortino Ratio Rank: 92
XBI Omega Ratio Rank: 85
XBI Calmar Ratio Rank: 96
XBI Martin Ratio Rank: 96

AVXL

AVXL Risk / Return Rank: 11
AVXL Sharpe Ratio Rank: 10
AVXL Sortino Ratio Rank: 12
AVXL Omega Ratio Rank: 10
AVXL Calmar Ratio Rank: 11
AVXL Martin Ratio Rank: 12

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

XBI vs. AVXL - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for SPDR S&P Biotech ETF (XBI) and Anavex Life Sciences Corp. (AVXL). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	XBI	AVXL	Difference
Sharpe ratio Return per unit of total volatility	2.13	-0.74	+2.87
Sortino ratio Return per unit of downside risk	2.83	-0.91	+3.75
Omega ratio Gain probability vs. loss probability	1.36	0.86	+0.50
Calmar ratio Return relative to maximum drawdown	4.90	-0.79	+5.69
Martin ratio Return relative to average drawdown	17.98	-1.34	+19.33
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

XBI vs. AVXL - Sharpe Ratio Comparison

The current XBI Sharpe Ratio is 2.13, which is higher than the AVXL Sharpe Ratio of -0.74. The chart below compares the historical Sharpe Ratios of XBI and AVXL, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	XBI	AVXL	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.13	-0.74	+2.87
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.03	-0.34	+0.30
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.29	-0.07	+0.36
Sharpe Ratio (All Time) Calculated using the full available price history	0.36	-0.05	+0.42

Correlation

The correlation between XBI and AVXL is 0.28, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

XBI vs. AVXL - Dividend Comparison

XBI's dividend yield for the trailing twelve months is around 0.34%, while AVXL has not paid dividends to shareholders.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
XBI SPDR S&P Biotech ETF	0.34%	0.37%	0.15%	0.02%	0.00%	0.04%	0.20%	0.00%	0.28%	0.24%	0.26%	0.61%
AVXL Anavex Life Sciences Corp.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Drawdowns

XBI vs. AVXL - Drawdown Comparison

The maximum XBI drawdown since its inception was -63.89%, smaller than the maximum AVXL drawdown of -97.06%. Use the drawdown chart below to compare losses from any high point for XBI and AVXL.

Drawdown Indicators

	XBI	AVXL	Difference
Max Drawdown Largest peak-to-trough decline	-63.89%	-97.06%	+33.17%
Max Drawdown (1Y) Largest decline over 1 year	-10.67%	-79.57%	+68.90%
Max Drawdown (5Y) Largest decline over 5 years	-55.04%	-90.51%	+35.47%
Max Drawdown (10Y) Largest decline over 10 years	-63.89%	-90.51%	+26.62%
Current Drawdown Current decline from peak	-25.46%	-89.64%	+64.18%
Average Drawdown Average peak-to-trough decline	-20.91%	-64.89%	+43.98%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.65%	46.65%	-43.00%

Volatility

XBI vs. AVXL - Volatility Comparison

The current volatility for SPDR S&P Biotech ETF (XBI) is 11.09%, while Anavex Life Sciences Corp. (AVXL) has a volatility of 46.13%. This indicates that XBI experiences smaller price fluctuations and is considered to be less risky than AVXL based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	XBI	AVXL	Difference
Volatility (1M) Calculated over the trailing 1-month period	11.09%	46.13%	-35.04%
Volatility (6M) Calculated over the trailing 6-month period	19.22%	82.23%	-63.01%
Volatility (1Y) Calculated over the trailing 1-year period	28.69%	88.65%	-59.96%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	32.21%	83.13%	-50.92%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.14%	85.58%	-53.44%