TSVT vs. VOO

Last updated Apr 1, 2026

Compare and contrast key facts about 2seventy bio, Inc. (TSVT) and Vanguard S&P 500 ETF (VOO).

VOO is a passively managed fund by Vanguard that tracks the performance of the S&P 500 Index. It was launched on Sep 7, 2010.

Performance

TSVT vs. VOO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in 2seventy bio, Inc. (TSVT) and Vanguard S&P 500 ETF (VOO). The values are adjusted to include any dividend payments, if applicable.

TSVT vs. VOO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021
TSVT 2seventy bio, Inc.	0.00%	70.07%	-31.15%	-54.43%	-63.44%	86.13%
VOO Vanguard S&P 500 ETF	-4.42%	17.82%	24.98%	26.32%	-18.17%	2.56%

Returns By Period

TSVT

• 1D: —
• 1M: —
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

VOO

• 1D: 2.86%
• 1M: -5.01%
• YTD: -4.42%
• 6M: -1.84%
• 1Y: 17.67%
• 3Y*: 18.27%
• 5Y*: 11.75%
• 10Y*: 14.05%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TSVT vs. VOO — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

VOO

VOO Risk / Return Rank: 65
VOO Sharpe Ratio Rank: 59
VOO Sortino Ratio Rank: 62
VOO Omega Ratio Rank: 66
VOO Calmar Ratio Rank: 65
VOO Martin Ratio Rank: 75

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TSVT vs. VOO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for 2seventy bio, Inc. (TSVT) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	TSVT	VOO	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	0.98	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.70	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.78	—
Sharpe Ratio (All Time) Calculated using the full available price history	—	0.83	—

Correlation

The correlation between TSVT and VOO is 0.30, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

TSVT vs. VOO - Dividend Comparison

TSVT has not paid dividends to shareholders, while VOO's dividend yield for the trailing twelve months is around 1.19%.

	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
TSVT 2seventy bio, Inc.	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%
VOO Vanguard S&P 500 ETF	1.19%	1.13%	1.24%	1.46%	1.69%	1.25%	1.54%	1.88%	2.06%	1.78%	2.02%	2.10%

Drawdowns

Drawdown Indicators

	TSVT	VOO	Difference
Max Drawdown Largest peak-to-trough decline	—	-33.99%	—
Max Drawdown (1Y) Largest decline over 1 year	—	-11.98%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-24.52%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-33.99%	—
Current Drawdown Current decline from peak	—	-6.29%	—
Average Drawdown Average peak-to-trough decline	—	-3.72%	—
Ulcer Index Depth and duration of drawdowns from previous peaks	—	2.52%	—

Volatility

Volatility by Period

	TSVT	VOO	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	5.29%	—
Volatility (6M) Calculated over the trailing 6-month period	—	9.44%	—
Volatility (1Y) Calculated over the trailing 1-year period	—	18.10%	—
Volatility (5Y) Calculated over the trailing 5-year period, annualized	—	16.82%	—
Volatility (10Y) Calculated over the trailing 10-year period, annualized	—	17.99%	—