TSHA vs. OPEN

Last updated Jun 4, 2026

TSHA (Taysha Gene Therapies, Inc.) and OPEN (Opendoor Technologies Inc.) are both stocks. TSHA operates in Biotechnology (Healthcare), while OPEN operates in Real Estate - Services (Real Estate). Over the past 5 years, TSHA returned -24.30%/yr vs -21.02%/yr for OPEN. At a 0.25 correlation, their price movements are largely independent.

Performance

TSHA vs. OPEN - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Taysha Gene Therapies, Inc. (TSHA) and Opendoor Technologies Inc. (OPEN). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TSHA achieves a 0.91% return, which is significantly higher than OPEN's -16.47% return.

TSHA

• 1D: -2.46%
• 1M: -16.42%
• YTD: 0.91%
• 6M: 23.61%
• 1Y: 99.64%
• 3Y*: 91.52%
• 5Y*: -24.30%
• 10Y*: —

OPEN

• 1D: -9.98%
• 1M: -5.07%
• YTD: -16.47%
• 6M: -29.83%
• 1Y: 751.93%
• 3Y*: 26.60%
• 5Y*: -21.02%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

TSHA vs. OPEN - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
TSHA Taysha Gene Therapies, Inc.	0.91%	217.92%	-2.26%	-21.68%	-80.60%	-56.10%	10.31%
OPEN Opendoor Technologies Inc.	-16.47%	276.52%	-64.29%	286.21%	-92.06%	-35.72%	43.05%

Correlation

The correlation between TSHA and OPEN is 0.13, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.13
Correlation (3Y) Calculated over the trailing 3-year period	0.21
Correlation (5Y) Calculated over the trailing 5-year period	0.26
Correlation (All Time) Calculated using the full available price history since Sep 25, 2020	0.25

The correlation between TSHA and OPEN shifts across timeframes, from 0.13 (1 year) to 0.26 (5 years), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap TSHA : $2.03B OPEN : $4.67B
EPS TSHA : -$0.39 OPEN : -$1.74
PS Ratio TSHA : 248.42 OPEN : 0.99
PB Ratio TSHA : 9.60 OPEN : 4.90
Total Revenue (TTM) TSHA : $7.47M OPEN : $3.94B
Gross Profit (TTM) TSHA : $6.89M OPEN : $312.00M
EBITDA (TTM) TSHA : -$130.51M OPEN : -$1.25B

Return for Risk

TSHA vs. OPEN — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TSHA

TSHA Risk / Return Rank: 79
TSHA Sharpe Ratio Rank: 75
TSHA Sortino Ratio Rank: 81
TSHA Omega Ratio Rank: 76
TSHA Calmar Ratio Rank: 83
TSHA Martin Ratio Rank: 80

OPEN

OPEN Risk / Return Rank: 96
OPEN Sharpe Ratio Rank: 98
OPEN Sortino Ratio Rank: 96
OPEN Omega Ratio Rank: 93
OPEN Calmar Ratio Rank: 98
OPEN Martin Ratio Rank: 95

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TSHA vs. OPEN - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Taysha Gene Therapies, Inc. (TSHA) and Opendoor Technologies Inc. (OPEN). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TSHA	OPEN	Difference
Sharpe ratio: Return per unit of total volatility	1.15	4.73	-3.58
Sortino ratio: Return per unit of downside risk	2.43	4.44	-2.01
Omega ratio: Gain probability vs. loss probability	1.27	1.52	-0.24
Calmar ratio: Return relative to maximum drawdown	3.22	13.10	-9.88
Martin ratio: Return relative to average drawdown	6.60	20.51	-13.92
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TSHA vs. OPEN - Sharpe Ratio Comparison

The current TSHA Sharpe Ratio is 1.15, which is lower than the OPEN Sharpe Ratio of 4.73. The chart below compares the historical Sharpe Ratios of TSHA and OPEN, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	TSHA	OPEN	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	1.15	4.73	-3.58
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.18	-0.19	+0.01
Sharpe Ratio (All Time) Calculated using the full available price history	-0.17	-0.11	-0.07

Drawdowns

TSHA vs. OPEN - Drawdown Comparison

The maximum TSHA drawdown since its inception was -98.14%, roughly equal to the maximum OPEN drawdown of -98.57%. Use the drawdown chart below to compare losses from any high point for TSHA and OPEN.

Drawdown Indicators

	TSHA	OPEN	Difference
Max Drawdown Largest peak-to-trough decline	-98.14%	-98.57%	+0.43%
Max Drawdown (1Y) Largest decline over 1 year	-31.13%	-57.96%	+26.83%
Max Drawdown (3Y) Largest decline over 3 years	-72.90%	-90.28%	+17.38%
Max Drawdown (5Y) Largest decline over 5 years	-97.76%	-97.93%	+0.17%
Current Drawdown Current decline from peak	-82.52%	-85.97%	+3.45%
Average Drawdown Average peak-to-trough decline	-76.86%	-74.57%	-2.29%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.15%	36.94%	-21.79%

Volatility

TSHA vs. OPEN - Volatility Comparison

The current volatility for Taysha Gene Therapies, Inc. (TSHA) is 17.53%, while Opendoor Technologies Inc. (OPEN) has a volatility of 19.07%. This indicates that TSHA experiences smaller price fluctuations and is considered to be less risky than OPEN based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TSHA	OPEN	Difference
Volatility (1M) Calculated over the trailing 1-month period	17.53%	19.07%	-1.54%
Volatility (6M) Calculated over the trailing 6-month period	52.15%	52.34%	-0.19%
Volatility (1Y) Calculated over the trailing 1-year period	87.12%	160.45%	-73.33%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	136.60%	113.43%	+23.17%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	130.72%	110.47%	+20.25%

Dividends

TSHA vs. OPEN - Dividend Comparison

Neither TSHA nor OPEN has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TSHA and OPEN in my portfolio?

TSHA and OPEN have a correlation of 0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TSHA or OPEN?

OPEN has higher volatility (19.07%) compared to TSHA (17.53%). In terms of maximum drawdown, TSHA dropped -98.14% vs OPEN's -98.57%.

Which has better risk-adjusted returns?

OPEN currently has the higher Sharpe Ratio (4.73 vs 1.15), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.