TSHA vs. OLMA

Last updated Jun 23, 2026

TSHA (Taysha Gene Therapies, Inc.) and OLMA (Olema Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, TSHA returned -23.63%/yr vs -17.80%/yr for OLMA. At a 0.31 correlation, their price movements are largely independent.

Performance

TSHA vs. OLMA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Taysha Gene Therapies, Inc. (TSHA) and Olema Pharmaceuticals, Inc. (OLMA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TSHA achieves a 18.73% return, which is significantly higher than OLMA's -60.00% return.

TSHA

• 1D: 1.71%
• 1M: 18.94%
• YTD: 18.73%
• 6M: 11.43%
• 1Y: 165.45%
• 3Y*: 114.68%
• 5Y*: -23.63%
• 10Y*: —

OLMA

• 1D: 5.15%
• 1M: -26.90%
• YTD: -60.00%
• 6M: -64.51%
• 1Y: 142.13%
• 3Y*: 8.31%
• 5Y*: -17.80%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

TSHA vs. OLMA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
TSHA Taysha Gene Therapies, Inc.	18.73%	217.92%	-2.26%	-21.68%	-80.60%	-56.10%	26.38%
OLMA Olema Pharmaceuticals, Inc.	-60.00%	328.82%	-58.45%	472.65%	-73.82%	-80.53%	6.84%

Correlation

The correlation between TSHA and OLMA is 0.39, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.39
Correlation (3Y) Calculated over the trailing 3-year period	0.31
Correlation (5Y) Calculated over the trailing 5-year period	0.31
Correlation (All Time) Calculated using the full available price history since Nov 19, 2020	0.31

Fundamentals

Market Cap TSHA : $2.39B OLMA : $1.03B
EPS TSHA : -$0.39 OLMA : -$2.03
PB Ratio TSHA : 11.30 OLMA : 2.14
Total Revenue (TTM) TSHA : $7.47M OLMA : $0.00
Gross Profit (TTM) TSHA : $6.89M OLMA : -$187.00K
EBITDA (TTM) TSHA : -$130.51M OLMA : -$197.79M

Return for Risk

TSHA vs. OLMA — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TSHA

TSHA Risk / Return Rank: 89
TSHA Sharpe Ratio Rank: 87
TSHA Sortino Ratio Rank: 90
TSHA Omega Ratio Rank: 86
TSHA Calmar Ratio Rank: 93
TSHA Martin Ratio Rank: 89

OLMA

OLMA Risk / Return Rank: 79
OLMA Sharpe Ratio Rank: 69
OLMA Sortino Ratio Rank: 91
OLMA Omega Ratio Rank: 90
OLMA Calmar Ratio Rank: 75
OLMA Martin Ratio Rank: 72

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TSHA vs. OLMA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Taysha Gene Therapies, Inc. (TSHA) and Olema Pharmaceuticals, Inc. (OLMA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	TSHA	OLMA	Difference
Sharpe ratio: Return per unit of total volatility	1.91	0.89	+1.01
Sortino ratio: Return per unit of downside risk	3.14	3.24	-0.10
Omega ratio: Gain probability vs. loss probability	1.36	1.41	-0.05
Calmar ratio: Return relative to maximum drawdown	5.35	1.92	+3.42
Martin ratio: Return relative to average drawdown	11.14	3.89	+7.25

TSHA vs. OLMA - Sharpe Ratio Comparison

The current TSHA Sharpe Ratio is 1.91, which is higher than the OLMA Sharpe Ratio of 0.89. The chart below compares the historical Sharpe Ratios of TSHA and OLMA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

TSHA vs. OLMA - Drawdown Comparison

The maximum TSHA drawdown since its inception was -98.14%, roughly equal to the maximum OLMA drawdown of -96.26%. Use the drawdown chart below to compare losses from any high point for TSHA and OLMA.

Drawdown Indicators

	TSHA	OLMA	Difference
Max Drawdown Largest peak-to-trough decline	-98.14%	-96.26%	-1.88%
Max Drawdown (1Y) Largest decline over 1 year	-31.13%	-74.35%	+43.22%
Max Drawdown (3Y) Largest decline over 3 years	-72.90%	-82.15%	+9.25%
Max Drawdown (5Y) Largest decline over 5 years	-97.76%	-93.36%	-4.40%
Current Drawdown Current decline from peak	-79.43%	-81.65%	+2.22%
Average Drawdown Average peak-to-trough decline	-76.85%	-74.99%	-1.86%
Ulcer Index Depth and duration of drawdowns from previous peaks	14.91%	36.69%	-21.78%

Volatility

TSHA vs. OLMA - Volatility Comparison

The current volatility for Taysha Gene Therapies, Inc. (TSHA) is 15.00%, while Olema Pharmaceuticals, Inc. (OLMA) has a volatility of 22.54%. This indicates that TSHA experiences smaller price fluctuations and is considered to be less risky than OLMA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TSHA	OLMA	Difference
Volatility (1M) Calculated over the trailing 1-month period	15.00%	22.54%	-7.54%
Volatility (6M) Calculated over the trailing 6-month period	49.27%	53.62%	-4.35%
Volatility (1Y) Calculated over the trailing 1-year period	87.56%	160.85%	-73.29%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	136.69%	107.89%	+28.80%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	130.29%	106.13%	+24.16%

Dividends

TSHA vs. OLMA - Dividend Comparison

Neither TSHA nor OLMA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TSHA and OLMA in my portfolio?

TSHA and OLMA have a correlation of 0.39, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TSHA or OLMA?

OLMA has higher volatility (22.54%) compared to TSHA (15.00%). In terms of maximum drawdown, TSHA dropped -98.14% vs OLMA's -96.26%.

Which has better risk-adjusted returns?

TSHA currently has the higher Sharpe Ratio (1.91 vs 0.89), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.