TSHA vs. OLMA

Last updated Aug 1, 2026

TSHA (Taysha Gene Therapies, Inc.) and OLMA (Olema Pharmaceuticals, Inc.) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, TSHA returned -19.46%/yr vs -13.38%/yr for OLMA. Their 0.31 correlation means their historical movements had little consistent relationship.

Performance

TSHA vs. OLMA - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Taysha Gene Therapies, Inc. (TSHA) and Olema Pharmaceuticals, Inc. (OLMA). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TSHA achieves a 6.55% return, which is significantly higher than OLMA's -54.20% return.

TSHA

• 1D: -0.26%
• 1M: -10.26%
• 6M: 29.93%
• YTD: 6.55%
• 1Y: 122.81%
• 3Y*: 105.27%
• 5Y*: -19.46%
• 10Y*: —
• ALL TIME*: -20.40%

OLMA

• 1D: -3.13%
• 1M: -9.41%
• 6M: -55.48%
• YTD: -54.20%
• 1Y: 114.82%
• 3Y*: 8.04%
• 5Y*: -13.38%
• 10Y*: —
• ALL TIME*: -21.36%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
OLMA Olema Pharmaceuticals, Inc.	$9.29M	$12.39M	$17.04M
TSHA Taysha Gene Therapies, Inc.	$12.94M	$17.27M	$18.69M

TSHA vs. OLMA - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020
TSHA Taysha Gene Therapies, Inc.	6.55%	217.92%	-2.26%	-21.68%	-80.60%	-56.10%	26.38%
OLMA Olema Pharmaceuticals, Inc.	-54.20%	328.82%	-58.45%	472.65%	-73.82%	-80.53%	6.84%

Correlation

The correlation between TSHA and OLMA is 0.39, which is low. Their historical price movements had little consistent relationship.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.39
Correlation (3Y) Balances recent behavior with more history.	0.31
Correlation (5Y) Shows whether the relationship held over a longer period.	0.31
Correlation (All Time) Calculated using the full available price history since Nov 19, 2020	0.31

Fundamentals

Market Cap TSHA : $1.87B OLMA : $1.00B
EPS TSHA : -$0.37 OLMA : -$1.98
PB Ratio TSHA : 10.14 OLMA : 2.45
Total Revenue (TTM) TSHA : $7.47M OLMA : $0.00
Gross Profit (TTM) TSHA : $6.89M OLMA : -$187.00K
EBITDA (TTM) TSHA : -$130.51M OLMA : -$197.79M

Return for Risk

TSHA vs. OLMA — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

TSHA

TSHA Risk / Return Rank: 85
TSHA Sharpe Ratio Rank: 81
TSHA Sortino Ratio Rank: 86
TSHA Omega Ratio Rank: 83
TSHA Calmar Ratio Rank: 91
TSHA Martin Ratio Rank: 86

OLMA

OLMA Risk / Return Rank: 80
OLMA Sharpe Ratio Rank: 70
OLMA Sortino Ratio Rank: 93
OLMA Omega Ratio Rank: 91
OLMA Calmar Ratio Rank: 76
OLMA Martin Ratio Rank: 70

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

TSHA vs. OLMA - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Taysha Gene Therapies, Inc. (TSHA) and Olema Pharmaceuticals, Inc. (OLMA). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	TSHA	OLMA	Difference
Sharpe ratio: Return per unit of total volatility	1.28	0.77	+0.51
Sortino ratio: Return per unit of downside risk	2.46	3.09	-0.63
Omega ratio: Gain probability vs. loss probability	1.29	1.39	-0.10
Calmar ratio: Return relative to maximum drawdown	3.70	1.66	+2.04
Martin ratio: Return relative to average drawdown	7.37	2.87	+4.50

TSHA vs. OLMA - Sharpe Ratio Comparison

The current TSHA Sharpe Ratio is 1.28, which is higher than the OLMA Sharpe Ratio of 0.77. The chart below compares the historical Sharpe Ratios of TSHA and OLMA, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

TSHA vs. OLMA - Drawdown Comparison

The maximum TSHA drawdown since its inception was -98.14%, roughly equal to the maximum OLMA drawdown of -96.26%. Use the drawdown chart below to compare losses from any high point for TSHA and OLMA.

Drawdown Indicators

	TSHA	OLMA	Difference
Max Drawdown Largest peak-to-trough decline	-98.14%	-96.26%	-1.88%
Max Drawdown (1Y) Largest decline over 1 year	-31.13%	-74.35%	+43.22%
Max Drawdown (3Y) Largest decline over 3 years	-72.90%	-82.15%	+9.25%
Max Drawdown (5Y) Largest decline over 5 years	-97.26%	-93.36%	-3.90%
Current Drawdown Current decline from peak	-81.54%	-78.99%	-2.55%
Average Drawdown Average peak-to-trough decline	-76.92%	-75.06%	-1.86%
Ulcer Index Depth and duration of drawdowns from previous peaks	15.61%	42.93%	-27.32%

Volatility

TSHA vs. OLMA - Volatility Comparison

Taysha Gene Therapies, Inc. (TSHA) has a higher volatility of 23.33% compared to Olema Pharmaceuticals, Inc. (OLMA) at 13.68%. This indicates that TSHA's price experiences larger fluctuations and is considered to be riskier than OLMA based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TSHA	OLMA	Difference
Volatility (1M) Calculated over the trailing 1-month period	23.33%	13.68%	+9.65%
Volatility (6M) Calculated over the trailing 6-month period	51.71%	51.96%	-0.25%
Volatility (1Y) Calculated over the trailing 1-year period	90.03%	160.11%	-70.08%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	136.69%	107.79%	+28.90%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	129.49%	105.35%	+24.14%

Dividends

TSHA vs. OLMA - Dividend Comparison

Neither TSHA nor OLMA has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TSHA and OLMA in my portfolio?

TSHA and OLMA have a correlation of 0.39, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TSHA or OLMA?

TSHA has higher volatility (23.33%) compared to OLMA (13.68%). In terms of maximum drawdown, TSHA dropped -98.14% vs OLMA's -96.26%.

Which has better risk-adjusted returns?

TSHA currently has the higher Sharpe Ratio (1.28 vs 0.77), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.