TRUP vs. UTHR

Last updated Apr 1, 2026

Compare and contrast key facts about Trupanion, Inc. (TRUP) and United Therapeutics Corporation (UTHR).

Performance

TRUP vs. UTHR - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Trupanion, Inc. (TRUP) and United Therapeutics Corporation (UTHR). The values are adjusted to include any dividend payments, if applicable.

TRUP vs. UTHR - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
TRUP Trupanion, Inc.	-31.47%	-22.47%	57.98%	-35.81%	-64.00%	10.29%	219.57%	47.13%	-13.02%	88.60%
UTHR United Therapeutics Corporation	21.70%	38.09%	60.46%	-20.93%	28.70%	42.35%	72.33%	-19.12%	-26.39%	3.15%

Fundamentals

Market Cap TRUP : $1.12B UTHR : $28.40B
EPS TRUP : $0.45 UTHR : $27.90
PE Ratio TRUP : 57.31 UTHR : 21.25
PS Ratio TRUP : 0.77 UTHR : 8.91
PB Ratio TRUP : 2.91 UTHR : 4.00
Total Revenue (TTM) TRUP : $1.44B UTHR : $3.18B
Gross Profit (TTM) TRUP : $280.02M UTHR : $2.80B
EBITDA (TTM) TRUP : $51.59M UTHR : $1.82B

Returns By Period

In the year-to-date period, TRUP achieves a -31.47% return, which is significantly lower than UTHR's 21.70% return. Over the past 10 years, TRUP has underperformed UTHR with an annualized return of 10.18%, while UTHR has yielded a comparatively higher 18.04% annualized return.

TRUP

• 1D: -0.70%
• 1M: -3.50%
• YTD: -31.47%
• 6M: -40.83%
• 1Y: -31.29%
• 3Y*: -15.79%
• 5Y*: -20.05%
• 10Y*: 10.18%

UTHR

• 1D: 0.79%
• 1M: 17.68%
• YTD: 21.70%
• 6M: 41.45%
• 1Y: 92.36%
• 3Y*: 38.34%
• 5Y*: 25.25%
• 10Y*: 18.04%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

TRUP vs. UTHR — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TRUP

TRUP Risk / Return Rank: 18
TRUP Sharpe Ratio Rank: 13
TRUP Sortino Ratio Rank: 13
TRUP Omega Ratio Rank: 15
TRUP Calmar Ratio Rank: 25
TRUP Martin Ratio Rank: 24

UTHR

UTHR Risk / Return Rank: 93
UTHR Sharpe Ratio Rank: 89
UTHR Sortino Ratio Rank: 94
UTHR Omega Ratio Rank: 94
UTHR Calmar Ratio Rank: 95
UTHR Martin Ratio Rank: 94

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TRUP vs. UTHR - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Trupanion, Inc. (TRUP) and United Therapeutics Corporation (UTHR). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	TRUP	UTHR	Difference
Sharpe ratio Return per unit of total volatility	-0.66	1.84	-2.50
Sortino ratio Return per unit of downside risk	-0.88	3.30	-4.17
Omega ratio Gain probability vs. loss probability	0.90	1.46	-0.56
Calmar ratio Return relative to maximum drawdown	-0.52	5.70	-6.22
Martin ratio Return relative to average drawdown	-1.00	14.49	-15.49
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

TRUP vs. UTHR - Sharpe Ratio Comparison

The current TRUP Sharpe Ratio is -0.66, which is lower than the UTHR Sharpe Ratio of 1.84. The chart below compares the historical Sharpe Ratios of TRUP and UTHR, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.

Sharpe Ratios by Period

	TRUP	UTHR	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.66	1.84	-2.50
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.28	0.72	-1.00
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.16	0.51	-0.35
Sharpe Ratio (All Time) Calculated using the full available price history	0.12	0.39	-0.27

Correlation

The correlation between TRUP and UTHR is 0.17, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

TRUP vs. UTHR - Dividend Comparison

Neither TRUP nor UTHR has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

TRUP vs. UTHR - Drawdown Comparison

The maximum TRUP drawdown since its inception was -87.34%, smaller than the maximum UTHR drawdown of -93.18%. Use the drawdown chart below to compare losses from any high point for TRUP and UTHR.

Drawdown Indicators

	TRUP	UTHR	Difference
Max Drawdown Largest peak-to-trough decline	-87.34%	-93.18%	+5.84%
Max Drawdown (1Y) Largest decline over 1 year	-56.17%	-16.35%	-39.82%
Max Drawdown (5Y) Largest decline over 5 years	-87.34%	-33.00%	-54.34%
Max Drawdown (10Y) Largest decline over 10 years	-87.34%	-55.56%	-31.78%
Current Drawdown Current decline from peak	-83.52%	0.00%	-83.52%
Average Drawdown Average peak-to-trough decline	-39.38%	-35.53%	-3.85%
Ulcer Index Depth and duration of drawdowns from previous peaks	29.39%	6.43%	+22.96%

Volatility

TRUP vs. UTHR - Volatility Comparison

The current volatility for Trupanion, Inc. (TRUP) is 12.80%, while United Therapeutics Corporation (UTHR) has a volatility of 17.05%. This indicates that TRUP experiences smaller price fluctuations and is considered to be less risky than UTHR based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TRUP	UTHR	Difference
Volatility (1M) Calculated over the trailing 1-month period	12.80%	17.05%	-4.25%
Volatility (6M) Calculated over the trailing 6-month period	30.13%	26.84%	+3.29%
Volatility (1Y) Calculated over the trailing 1-year period	47.46%	50.41%	-2.95%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	71.69%	35.89%	+35.80%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	62.47%	35.32%	+27.15%

Financials

TRUP vs. UTHR - Profitability Comparison

The chart below illustrates the profitability comparison between Trupanion, Inc. and United Therapeutics Corporation over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

TRUP - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Trupanion, Inc. reported a gross profit of 114.04M and revenue of 376.85M. Therefore, the gross margin over that period was 30.3%.

UTHR - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, United Therapeutics Corporation reported a gross profit of 686.80M and revenue of 790.20M. Therefore, the gross margin over that period was 86.9%.

TRUP - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Trupanion, Inc. reported an operating income of 6.29M and revenue of 376.85M, resulting in an operating margin of 1.7%.

UTHR - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, United Therapeutics Corporation reported an operating income of 356.70M and revenue of 790.20M, resulting in an operating margin of 45.1%.

TRUP - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Trupanion, Inc. reported a net income of 5.63M and revenue of 376.85M, resulting in a net margin of 1.5%.

UTHR - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, United Therapeutics Corporation reported a net income of 364.30M and revenue of 790.20M, resulting in a net margin of 46.1%.