TLSA vs. UBER

Last updated Jun 23, 2026

TLSA (Tiziana Life Sciences PLC) and UBER (Uber Technologies, Inc.) are both stocks. TLSA operates in Biotechnology (Healthcare), while UBER operates in Software - Application (Technology). Over the past 5 years, TLSA returned -13.75%/yr vs 7.18%/yr for UBER. At a 0.09 correlation, their price movements are largely independent.

Performance

TLSA vs. UBER - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Tiziana Life Sciences PLC (TLSA) and Uber Technologies, Inc. (UBER). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, TLSA achieves a -22.82% return, which is significantly lower than UBER's -12.58% return.

TLSA

• 1D: -0.86%
• 1M: -22.30%
• YTD: -22.82%
• 6M: -25.32%
• 1Y: -26.28%
• 3Y*: 16.89%
• 5Y*: -13.75%
• 10Y*: —

UBER

• 1D: -0.29%
• 1M: -0.54%
• YTD: -12.58%
• 6M: -12.10%
• 1Y: -14.74%
• 3Y*: 18.12%
• 5Y*: 7.18%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

TLSA vs. UBER - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
TLSA Tiziana Life Sciences PLC	-22.82%	114.02%	24.32%	-6.43%	-37.66%	-52.48%	86.96%	-33.90%
UBER Uber Technologies, Inc.	-12.58%	35.46%	-2.03%	148.97%	-41.02%	-17.78%	71.49%	-29.19%

Correlation

The correlation between TLSA and UBER is 0.12, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.12
Correlation (3Y) Calculated over the trailing 3-year period	0.11
Correlation (5Y) Calculated over the trailing 5-year period	0.10
Correlation (All Time) Calculated using the full available price history since May 10, 2019	0.09

Fundamentals

Market Cap TLSA : $68.39M UBER : $147.96B
EPS TLSA : -$0.59 UBER : $4.05
PB Ratio TLSA : 1.32K UBER : 5.98
Total Revenue (TTM) TLSA : $0.00 UBER : $53.69B
Gross Profit (TTM) TLSA : -$421.00K UBER : $22.03B
EBITDA (TTM) TLSA : -$42.26M UBER : $5.85B

Return for Risk

TLSA vs. UBER — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

TLSA

TLSA Risk / Return Rank: 29
TLSA Sharpe Ratio Rank: 28
TLSA Sortino Ratio Rank: 32
TLSA Omega Ratio Rank: 31
TLSA Calmar Ratio Rank: 26
TLSA Martin Ratio Rank: 28

UBER

UBER Risk / Return Rank: 23
UBER Sharpe Ratio Rank: 22
UBER Sortino Ratio Rank: 21
UBER Omega Ratio Rank: 22
UBER Calmar Ratio Rank: 26
UBER Martin Ratio Rank: 26

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

TLSA vs. UBER - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Tiziana Life Sciences PLC (TLSA) and Uber Technologies, Inc. (UBER). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	TLSA	UBER	Difference
Sharpe ratio: Return per unit of total volatility	-0.33	-0.45	+0.11
Sortino ratio: Return per unit of downside risk	0.00	-0.46	+0.46
Omega ratio: Gain probability vs. loss probability	1.00	0.95	+0.05
Calmar ratio: Return relative to maximum drawdown	-0.46	-0.47	+0.01
Martin ratio: Return relative to average drawdown	-0.73	-0.80	+0.07

TLSA vs. UBER - Sharpe Ratio Comparison

The current TLSA Sharpe Ratio is -0.33, which is comparable to the UBER Sharpe Ratio of -0.45. The chart below compares the historical Sharpe Ratios of TLSA and UBER, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

TLSA vs. UBER - Drawdown Comparison

The maximum TLSA drawdown since its inception was -94.03%, which is greater than UBER's maximum drawdown of -68.05%. Use the drawdown chart below to compare losses from any high point for TLSA and UBER.

Drawdown Indicators

	TLSA	UBER	Difference
Max Drawdown Largest peak-to-trough decline	-94.03%	-68.05%	-25.98%
Max Drawdown (1Y) Largest decline over 1 year	-56.80%	-31.46%	-25.34%
Max Drawdown (3Y) Largest decline over 3 years	-56.80%	-31.46%	-25.34%
Max Drawdown (5Y) Largest decline over 5 years	-83.32%	-60.45%	-22.87%
Current Drawdown Current decline from peak	-83.55%	-28.64%	-54.91%
Average Drawdown Average peak-to-trough decline	-70.34%	-25.68%	-44.66%
Ulcer Index Depth and duration of drawdowns from previous peaks	36.04%	18.36%	+17.68%

Volatility

TLSA vs. UBER - Volatility Comparison

Tiziana Life Sciences PLC (TLSA) has a higher volatility of 21.41% compared to Uber Technologies, Inc. (UBER) at 10.44%. This indicates that TLSA's price experiences larger fluctuations and is considered to be riskier than UBER based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	TLSA	UBER	Difference
Volatility (1M) Calculated over the trailing 1-month period	21.41%	10.44%	+10.97%
Volatility (6M) Calculated over the trailing 6-month period	53.63%	23.69%	+29.94%
Volatility (1Y) Calculated over the trailing 1-year period	79.37%	33.28%	+46.09%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	92.70%	44.89%	+47.81%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	112.57%	50.60%	+61.97%

Dividends

TLSA vs. UBER - Dividend Comparison

Neither TLSA nor UBER has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both TLSA and UBER in my portfolio?

TLSA and UBER have a correlation of 0.12, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, TLSA or UBER?

TLSA has higher volatility (21.41%) compared to UBER (10.44%). In terms of maximum drawdown, TLSA dropped -94.03% vs UBER's -68.05%.

Which has better risk-adjusted returns?

TLSA currently has the higher Sharpe Ratio (-0.33 vs -0.45), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.