LLY vs. VRTX
Compare and contrast key facts about Eli Lilly and Company (LLY) and Vertex Pharmaceuticals Incorporated (VRTX).
Performance
LLY vs. VRTX - Performance Comparison
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LLY vs. VRTX - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
LLY Eli Lilly and Company | -14.27% | 40.25% | 33.30% | 60.91% | 34.26% | 66.08% | 31.04% | 16.14% | 40.45% | 17.83% |
VRTX Vertex Pharmaceuticals Incorporated | -1.50% | 12.58% | -1.03% | 40.90% | 31.50% | -7.08% | 7.94% | 32.13% | 10.58% | 103.42% |
Fundamentals
LLY:
$825.96B
VRTX:
$114.36B
LLY:
$22.96
VRTX:
$15.35
LLY:
40.06
VRTX:
29.09
LLY:
0.81
VRTX:
2.42
LLY:
12.68
VRTX:
9.58
LLY:
31.13
VRTX:
6.13
LLY:
$65.18B
VRTX:
$12.00B
LLY:
$54.62B
VRTX:
$10.35B
LLY:
$27.94B
VRTX:
$4.74B
Returns By Period
In the year-to-date period, LLY achieves a -14.27% return, which is significantly lower than VRTX's -1.50% return. Over the past 10 years, LLY has outperformed VRTX with an annualized return of 30.92%, while VRTX has yielded a comparatively lower 18.89% annualized return.
LLY
- 1D
- 3.74%
- 1M
- -12.57%
- YTD
- -14.27%
- 6M
- 20.93%
- 1Y
- 12.19%
- 3Y*
- 39.90%
- 5Y*
- 39.16%
- 10Y*
- 30.92%
VRTX
- 1D
- 0.76%
- 1M
- -10.12%
- YTD
- -1.50%
- 6M
- 14.02%
- 1Y
- -7.90%
- 3Y*
- 12.33%
- 5Y*
- 15.95%
- 10Y*
- 18.89%
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Return for Risk
LLY vs. VRTX — Risk / Return Rank
LLY
VRTX
LLY vs. VRTX - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Eli Lilly and Company (LLY) and Vertex Pharmaceuticals Incorporated (VRTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| LLY | VRTX | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 0.29 | -0.22 | +0.51 |
Sortino ratioReturn per unit of downside risk | 0.69 | -0.05 | +0.74 |
Omega ratioGain probability vs. loss probability | 1.10 | 0.99 | +0.10 |
Calmar ratioReturn relative to maximum drawdown | 0.42 | -0.33 | +0.75 |
Martin ratioReturn relative to average drawdown | 1.02 | -0.65 | +1.68 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| LLY | VRTX | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 0.29 | -0.22 | +0.51 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 1.23 | 0.56 | +0.67 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 1.04 | 0.57 | +0.47 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.56 | 0.26 | +0.31 |
Correlation
The correlation between LLY and VRTX is 0.27, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.
Dividends
LLY vs. VRTX - Dividend Comparison
LLY's dividend yield for the trailing twelve months is around 0.68%, while VRTX has not paid dividends to shareholders.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
LLY Eli Lilly and Company | 0.68% | 0.56% | 0.67% | 0.78% | 1.07% | 1.23% | 1.75% | 1.96% | 1.94% | 2.46% | 2.77% | 2.37% |
VRTX Vertex Pharmaceuticals Incorporated | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
Drawdowns
LLY vs. VRTX - Drawdown Comparison
The maximum LLY drawdown since its inception was -68.24%, smaller than the maximum VRTX drawdown of -91.77%. Use the drawdown chart below to compare losses from any high point for LLY and VRTX.
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Drawdown Indicators
| LLY | VRTX | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -68.24% | -91.77% | +23.53% |
Max Drawdown (1Y)Largest decline over 1 year | -30.26% | -28.06% | -2.20% |
Max Drawdown (5Y)Largest decline over 5 years | -34.48% | -29.07% | -5.41% |
Max Drawdown (10Y)Largest decline over 10 years | -34.48% | -41.60% | +7.12% |
Current DrawdownCurrent decline from peak | -17.00% | -13.59% | -3.41% |
Average DrawdownAverage peak-to-trough decline | -19.25% | -37.81% | +18.56% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 12.39% | 14.33% | -1.94% |
Volatility
LLY vs. VRTX - Volatility Comparison
The current volatility for Eli Lilly and Company (LLY) is 9.04%, while Vertex Pharmaceuticals Incorporated (VRTX) has a volatility of 11.93%. This indicates that LLY experiences smaller price fluctuations and is considered to be less risky than VRTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| LLY | VRTX | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 9.04% | 11.93% | -2.89% |
Volatility (6M)Calculated over the trailing 6-month period | 26.21% | 21.67% | +4.54% |
Volatility (1Y)Calculated over the trailing 1-year period | 42.44% | 35.83% | +6.61% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 32.14% | 28.77% | +3.37% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 29.80% | 33.24% | -3.44% |
Financials
LLY vs. VRTX - Financials Comparison
This section allows you to compare key financial metrics between Eli Lilly and Company and Vertex Pharmaceuticals Incorporated. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.
Total Revenue: Total amount of money received from sales and other business activities
LLY vs. VRTX - Profitability Comparison
LLY - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a gross profit of 16.41B and revenue of 19.29B. Therefore, the gross margin over that period was 85.1%.
VRTX - Gross Margin
Gross margin is calculated as gross profit divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.72B and revenue of 3.19B. Therefore, the gross margin over that period was 85.4%.
LLY - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported an operating income of 8.78B and revenue of 19.29B, resulting in an operating margin of 45.5%.
VRTX - Operating Margin
Operating margin is calculated as operating income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported an operating income of 1.26B and revenue of 3.19B, resulting in an operating margin of 39.6%.
LLY - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Eli Lilly and Company reported a net income of 6.64B and revenue of 19.29B, resulting in a net margin of 34.4%.
VRTX - Net Margin
Net margin is calculated as net income divided by revenue. For the three months ending on Apr 2026, Vertex Pharmaceuticals Incorporated reported a net income of 1.19B and revenue of 3.19B, resulting in a net margin of 37.3%.