JFNAX vs. VOO
Compare and contrast key facts about Janus Henderson Global Life Sciences Fund Class A (JFNAX) and Vanguard S&P 500 ETF (VOO).
JFNAX is managed by Janus Henderson. It was launched on Dec 31, 1998. VOO is a passively managed fund by Vanguard that tracks the performance of the S&P 500 Index. It was launched on Sep 7, 2010.
Performance
JFNAX vs. VOO - Performance Comparison
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JFNAX vs. VOO - Yearly Performance Comparison
| 2026 (YTD) | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|---|---|
JFNAX Janus Henderson Global Life Sciences Fund Class A | -3.77% | 24.61% | 3.41% | 7.35% | -2.86% | 6.59% | 25.42% | 28.98% | 4.00% | 22.35% |
VOO Vanguard S&P 500 ETF | -3.66% | 17.82% | 24.98% | 26.32% | -18.17% | 28.79% | 18.32% | 31.37% | -4.50% | 21.77% |
Returns By Period
The year-to-date returns for both investments are quite close, with JFNAX having a -3.77% return and VOO slightly higher at -3.66%. Over the past 10 years, JFNAX has underperformed VOO with an annualized return of 10.96%, while VOO has yielded a comparatively higher 14.14% annualized return.
JFNAX
- 1D
- 3.08%
- 1M
- -5.56%
- YTD
- -3.77%
- 6M
- 11.78%
- 1Y
- 21.47%
- 3Y*
- 10.49%
- 5Y*
- 7.15%
- 10Y*
- 10.96%
VOO
- 1D
- 0.79%
- 1M
- -4.29%
- YTD
- -3.66%
- 6M
- -1.41%
- 1Y
- 18.17%
- 3Y*
- 18.58%
- 5Y*
- 11.93%
- 10Y*
- 14.14%
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JFNAX vs. VOO - Expense Ratio Comparison
JFNAX has a 0.98% expense ratio, which is higher than VOO's 0.03% expense ratio.
Return for Risk
JFNAX vs. VOO — Risk / Return Rank
JFNAX
VOO
JFNAX vs. VOO - Risk-Adjusted Trends Comparison
This table presents a comparison of risk-adjusted performance metrics for Janus Henderson Global Life Sciences Fund Class A (JFNAX) and Vanguard S&P 500 ETF (VOO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.
| JFNAX | VOO | Difference | |
|---|---|---|---|
Sharpe ratioReturn per unit of total volatility | 1.06 | 1.01 | +0.05 |
Sortino ratioReturn per unit of downside risk | 1.52 | 1.53 | -0.01 |
Omega ratioGain probability vs. loss probability | 1.20 | 1.23 | -0.03 |
Calmar ratioReturn relative to maximum drawdown | 1.78 | 1.55 | +0.22 |
Martin ratioReturn relative to average drawdown | 4.89 | 7.31 | -2.42 |
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month. | |||
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Sharpe Ratios by Period
| JFNAX | VOO | Difference | |
|---|---|---|---|
Sharpe Ratio (1Y)Calculated over the trailing 1-year period | 1.06 | 1.01 | +0.05 |
Sharpe Ratio (5Y)Calculated over the trailing 5-year period | 0.46 | 0.71 | -0.26 |
Sharpe Ratio (10Y)Calculated over the trailing 10-year period | 0.63 | 0.79 | -0.16 |
Sharpe Ratio (All Time)Calculated using the full available price history | 0.83 | 0.83 | 0.00 |
Correlation
The correlation between JFNAX and VOO is 0.72, which is considered to be high. That indicates a strong positive relationship between their price movements. Having highly-correlated positions in a portfolio may signal a lack of diversification, potentially leading to increased risk during market downturns.
Dividends
JFNAX vs. VOO - Dividend Comparison
JFNAX's dividend yield for the trailing twelve months is around 4.73%, more than VOO's 1.18% yield.
| TTM | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
JFNAX Janus Henderson Global Life Sciences Fund Class A | 4.73% | 4.56% | 5.74% | 4.28% | 0.08% | 9.90% | 7.82% | 6.18% | 13.55% | 1.03% | 0.97% | 8.93% |
VOO Vanguard S&P 500 ETF | 1.18% | 1.13% | 1.24% | 1.46% | 1.69% | 1.25% | 1.54% | 1.88% | 2.06% | 1.78% | 2.02% | 2.10% |
Drawdowns
JFNAX vs. VOO - Drawdown Comparison
The maximum JFNAX drawdown since its inception was -31.07%, smaller than the maximum VOO drawdown of -33.99%. Use the drawdown chart below to compare losses from any high point for JFNAX and VOO.
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Drawdown Indicators
| JFNAX | VOO | Difference | |
|---|---|---|---|
Max DrawdownLargest peak-to-trough decline | -31.07% | -33.99% | +2.92% |
Max Drawdown (1Y)Largest decline over 1 year | -9.71% | -11.98% | +2.27% |
Max Drawdown (5Y)Largest decline over 5 years | -22.29% | -24.52% | +2.23% |
Max Drawdown (10Y)Largest decline over 10 years | -27.39% | -33.99% | +6.60% |
Current DrawdownCurrent decline from peak | -6.65% | -5.55% | -1.10% |
Average DrawdownAverage peak-to-trough decline | -6.31% | -3.72% | -2.59% |
Ulcer IndexDepth and duration of drawdowns from previous peaks | 3.63% | 2.55% | +1.08% |
Volatility
JFNAX vs. VOO - Volatility Comparison
Janus Henderson Global Life Sciences Fund Class A (JFNAX) has a higher volatility of 6.00% compared to Vanguard S&P 500 ETF (VOO) at 5.34%. This indicates that JFNAX's price experiences larger fluctuations and is considered to be riskier than VOO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.
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Volatility by Period
| JFNAX | VOO | Difference | |
|---|---|---|---|
Volatility (1M)Calculated over the trailing 1-month period | 6.00% | 5.34% | +0.66% |
Volatility (6M)Calculated over the trailing 6-month period | 10.64% | 9.47% | +1.17% |
Volatility (1Y)Calculated over the trailing 1-year period | 17.86% | 18.11% | -0.25% |
Volatility (5Y)Calculated over the trailing 5-year period, annualized | 15.70% | 16.82% | -1.12% |
Volatility (10Y)Calculated over the trailing 10-year period, annualized | 17.41% | 17.99% | -0.58% |