JAZZ vs. CRSP

Last updated Jun 4, 2026

JAZZ (Jazz Pharmaceuticals plc) and CRSP (CRISPR Therapeutics AG) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, JAZZ returned 5.88%/yr vs -14.40%/yr for CRSP. At a 0.30 correlation, their price movements are largely independent.

Performance

JAZZ vs. CRSP - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Jazz Pharmaceuticals plc (JAZZ) and CRISPR Therapeutics AG (CRSP). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, JAZZ achieves a 35.84% return, which is significantly higher than CRSP's -0.69% return.

JAZZ

• 1D: 2.13%
• 1M: 10.99%
• YTD: 35.84%
• 6M: 38.20%
• 1Y: 109.33%
• 3Y*: 21.63%
• 5Y*: 5.88%
• 10Y*: 4.22%

CRSP

• 1D: 0.12%
• 1M: -2.80%
• YTD: -0.69%
• 6M: -6.98%
• 1Y: 36.91%
• 3Y*: -7.12%
• 5Y*: -14.40%
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

JAZZ vs. CRSP - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
JAZZ Jazz Pharmaceuticals plc	35.84%	38.04%	0.12%	-22.79%	25.05%	-22.81%	10.56%	20.43%	-7.94%	23.50%
CRSP CRISPR Therapeutics AG	-0.69%	33.23%	-37.12%	54.00%	-46.36%	-50.51%	151.39%	113.18%	21.68%	15.89%

Correlation

The correlation between JAZZ and CRSP is 0.32, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.32
Correlation (3Y) Calculated over the trailing 3-year period	0.29
Correlation (5Y) Calculated over the trailing 5-year period	0.32
Correlation (All Time) Calculated using the full available price history since Oct 20, 2016	0.30

Fundamentals

Market Cap JAZZ : $15.26B CRSP : $5.00B
EPS JAZZ : $0.47 CRSP : -$6.24
PS Ratio JAZZ : 3.25 CRSP : 1.16K
PB Ratio JAZZ : 3.37 CRSP : 2.76
Total Revenue (TTM) JAZZ : $4.44B CRSP : $4.10M
Gross Profit (TTM) JAZZ : $2.97B CRSP : -$171.17M
EBITDA (TTM) JAZZ : $336.83M CRSP : -$509.21M

Return for Risk

JAZZ vs. CRSP — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

JAZZ

JAZZ Risk / Return Rank: 96
JAZZ Sharpe Ratio Rank: 94
JAZZ Sortino Ratio Rank: 96
JAZZ Omega Ratio Rank: 95
JAZZ Calmar Ratio Rank: 97
JAZZ Martin Ratio Rank: 96

CRSP

CRSP Risk / Return Rank: 58
CRSP Sharpe Ratio Rank: 60
CRSP Sortino Ratio Rank: 60
CRSP Omega Ratio Rank: 56
CRSP Calmar Ratio Rank: 59
CRSP Martin Ratio Rank: 55

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

JAZZ vs. CRSP - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Jazz Pharmaceuticals plc (JAZZ) and CRISPR Therapeutics AG (CRSP). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	JAZZ	CRSP	Difference
Sharpe ratio: Return per unit of total volatility	2.98	0.60	+2.38
Sortino ratio: Return per unit of downside risk	4.54	1.28	+3.26
Omega ratio: Gain probability vs. loss probability	1.57	1.15	+0.43
Calmar ratio: Return relative to maximum drawdown	9.63	0.88	+8.75
Martin ratio: Return relative to average drawdown	23.75	1.49	+22.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

JAZZ vs. CRSP - Sharpe Ratio Comparison

The current JAZZ Sharpe Ratio is 2.98, which is higher than the CRSP Sharpe Ratio of 0.60. The chart below compares the historical Sharpe Ratios of JAZZ and CRSP, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	JAZZ	CRSP	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	2.98	0.60	+2.38
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.19	-0.24	+0.43
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.13	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	0.19	0.23	-0.04

Drawdowns

JAZZ vs. CRSP - Drawdown Comparison

The maximum JAZZ drawdown since its inception was -96.90%, which is greater than CRSP's maximum drawdown of -85.11%. Use the drawdown chart below to compare losses from any high point for JAZZ and CRSP.

Drawdown Indicators

	JAZZ	CRSP	Difference
Max Drawdown Largest peak-to-trough decline	-96.90%	-85.11%	-11.79%
Max Drawdown (1Y) Largest decline over 1 year	-11.42%	-42.25%	+30.83%
Max Drawdown (3Y) Largest decline over 3 years	-32.71%	-64.91%	+32.20%
Max Drawdown (5Y) Largest decline over 5 years	-47.55%	-80.68%	+33.13%
Max Drawdown (10Y) Largest decline over 10 years	-52.10%	—	—
Current Drawdown Current decline from peak	-3.71%	-75.20%	+71.49%
Average Drawdown Average peak-to-trough decline	-27.42%	-49.17%	+21.75%
Ulcer Index Depth and duration of drawdowns from previous peaks	4.62%	24.92%	-20.30%

Volatility

JAZZ vs. CRSP - Volatility Comparison

The current volatility for Jazz Pharmaceuticals plc (JAZZ) is 9.90%, while CRISPR Therapeutics AG (CRSP) has a volatility of 14.90%. This indicates that JAZZ experiences smaller price fluctuations and is considered to be less risky than CRSP based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	JAZZ	CRSP	Difference
Volatility (1M) Calculated over the trailing 1-month period	9.90%	14.90%	-5.00%
Volatility (6M) Calculated over the trailing 6-month period	23.47%	42.49%	-19.02%
Volatility (1Y) Calculated over the trailing 1-year period	36.89%	61.68%	-24.79%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	31.75%	60.46%	-28.71%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	32.77%	64.27%	-31.50%

Dividends

JAZZ vs. CRSP - Dividend Comparison

Neither JAZZ nor CRSP has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both JAZZ and CRSP in my portfolio?

JAZZ and CRSP have a correlation of 0.32, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, JAZZ or CRSP?

CRSP has higher volatility (14.90%) compared to JAZZ (9.90%). In terms of maximum drawdown, JAZZ dropped -96.90% vs CRSP's -85.11%.

Which has better risk-adjusted returns?

JAZZ currently has the higher Sharpe Ratio (2.98 vs 0.60), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.