ITCI vs. AXSM

Last updated Apr 1, 2026

Compare and contrast key facts about Intra-Cellular Therapies, Inc. (ITCI) and Axsome Therapeutics, Inc. (AXSM).

Performance

ITCI vs. AXSM - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Intra-Cellular Therapies, Inc. (ITCI) and Axsome Therapeutics, Inc. (AXSM). The values are adjusted to include any dividend payments, if applicable.

ITCI vs. AXSM - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
ITCI Intra-Cellular Therapies, Inc.	0.00%	57.89%	16.62%	35.34%	1.11%	64.59%	-7.32%	201.23%	-21.34%	-4.04%
AXSM Axsome Therapeutics, Inc.	-7.46%	115.86%	6.31%	3.19%	104.16%	-53.63%	-21.18%	3,565.25%	-49.64%	-17.04%

Fundamentals

Total Revenue (TTM) ITCI : $680.64M AXSM : $638.50M
Gross Profit (TTM) ITCI : $623.67M AXSM : $591.02M
EBITDA (TTM) ITCI : -$116.21M AXSM : -$168.76M

Returns By Period

ITCI

• 1D: —
• 1M: —
• YTD: —
• 6M: —
• 1Y: —
• 3Y*: —
• 5Y*: —
• 10Y*: —

AXSM

• 1D: 5.31%
• 1M: 3.13%
• YTD: -7.46%
• 6M: 39.17%
• 1Y: 44.92%
• 3Y*: 39.94%
• 5Y*: 24.07%
• 10Y*: 34.16%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Return for Risk

ITCI vs. AXSM — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AXSM

AXSM Risk / Return Rank: 77
AXSM Sharpe Ratio Rank: 77
AXSM Sortino Ratio Rank: 77
AXSM Omega Ratio Rank: 73
AXSM Calmar Ratio Rank: 81
AXSM Martin Ratio Rank: 78

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

ITCI vs. AXSM - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Intra-Cellular Therapies, Inc. (ITCI) and Axsome Therapeutics, Inc. (AXSM). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Risk / return metrics aren't available yet — we need at least 12 months of trading data to calculate them.

Sharpe Ratios by Period

	ITCI	AXSM	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	—	1.11	—
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	—	0.34	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.38	—
Sharpe Ratio (All Time) Calculated using the full available price history	—	0.36	—

Correlation

The correlation between ITCI and AXSM is 0.33, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.

Dividends

ITCI vs. AXSM - Dividend Comparison

Neither ITCI nor AXSM has paid dividends to shareholders.

Tickers have no history of dividend payments

Drawdowns

Drawdown Indicators

	ITCI	AXSM	Difference
Max Drawdown Largest peak-to-trough decline	—	-86.65%	—
Max Drawdown (1Y) Largest decline over 1 year	—	-18.50%	—
Max Drawdown (5Y) Largest decline over 5 years	—	-72.91%	—
Max Drawdown (10Y) Largest decline over 10 years	—	-83.92%	—
Current Drawdown Current decline from peak	—	-10.62%	—
Average Drawdown Average peak-to-trough decline	—	-40.21%	—
Ulcer Index Depth and duration of drawdowns from previous peaks	—	8.21%	—

Volatility

Volatility by Period

	ITCI	AXSM	Difference
Volatility (1M) Calculated over the trailing 1-month period	—	11.02%	—
Volatility (6M) Calculated over the trailing 6-month period	—	30.60%	—
Volatility (1Y) Calculated over the trailing 1-year period	—	40.86%	—
Volatility (5Y) Calculated over the trailing 5-year period, annualized	—	70.52%	—
Volatility (10Y) Calculated over the trailing 10-year period, annualized	—	90.95%	—

Financials