CRBP vs. PRME

Last updated Jun 4, 2026

CRBP (Corbus Pharmaceuticals Holdings, Inc.) and PRME (Prime Medicine Inc. Common Stock) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 3 years, CRBP returned -9.17%/yr vs -42.02%/yr for PRME. At a 0.22 correlation, their price movements are largely independent.

Performance

CRBP vs. PRME - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Corbus Pharmaceuticals Holdings, Inc. (CRBP) and Prime Medicine Inc. Common Stock (PRME). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

The year-to-date returns for both stocks are quite close, with CRBP having a -9.34% return and PRME slightly lower at -9.51%.

CRBP

• 1D: -2.12%
• 1M: -29.85%
• YTD: -9.34%
• 6M: -30.83%
• 1Y: -11.08%
• 3Y*: -9.17%
• 5Y*: -34.10%
• 10Y*: -23.85%

PRME

• 1D: -2.18%
• 1M: -9.51%
• YTD: -9.51%
• 6M: -13.02%
• 1Y: 136.09%
• 3Y*: -42.02%
• 5Y*: —
• 10Y*: —

*Multi-year figures are annualized to reflect compound growth (CAGR)

CRBP vs. PRME - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022
CRBP Corbus Pharmaceuticals Holdings, Inc.	-9.34%	-31.02%	95.36%	82.20%	-17.84%
PRME Prime Medicine Inc. Common Stock	-9.51%	18.84%	-67.04%	-52.31%	20.88%

Correlation

The correlation between CRBP and PRME is 0.18, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.18
Correlation (3Y) Calculated over the trailing 3-year period	0.25
Correlation (All Time) Calculated using the full available price history since Oct 21, 2022	0.22

Fundamentals

Market Cap CRBP : $138.05M PRME : $556.08M
EPS CRBP : -$5.98 PRME : -$1.29
PB Ratio CRBP : 1.09 PRME : 7.25
Total Revenue (TTM) CRBP : $0.00 PRME : $3.18M
Gross Profit (TTM) CRBP : -$149.00K PRME : -$4.14M
EBITDA (TTM) CRBP : -$61.36M PRME : -$195.72M

Return for Risk

CRBP vs. PRME — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

CRBP

CRBP Risk / Return Rank: 37
CRBP Sharpe Ratio Rank: 35
CRBP Sortino Ratio Rank: 39
CRBP Omega Ratio Rank: 40
CRBP Calmar Ratio Rank: 35
CRBP Martin Ratio Rank: 35

PRME

PRME Risk / Return Rank: 76
PRME Sharpe Ratio Rank: 79
PRME Sortino Ratio Rank: 81
PRME Omega Ratio Rank: 73
PRME Calmar Ratio Rank: 77
PRME Martin Ratio Rank: 70

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

CRBP vs. PRME - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Corbus Pharmaceuticals Holdings, Inc. (CRBP) and Prime Medicine Inc. Common Stock (PRME). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	CRBP	PRME	Difference
Sharpe ratio: Return per unit of total volatility	-0.14	1.38	-1.52
Sortino ratio: Return per unit of downside risk	0.38	2.39	-2.00
Omega ratio: Gain probability vs. loss probability	1.05	1.25	-0.19
Calmar ratio: Return relative to maximum drawdown	-0.18	2.30	-2.48
Martin ratio: Return relative to average drawdown	-0.28	3.78	-4.06
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

CRBP vs. PRME - Sharpe Ratio Comparison

The current CRBP Sharpe Ratio is -0.14, which is lower than the PRME Sharpe Ratio of 1.38. The chart below compares the historical Sharpe Ratios of CRBP and PRME, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	CRBP	PRME	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	-0.14	1.38	-1.52
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.22	—	—
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	-0.19	—	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.15	-0.40	+0.24

Drawdowns

CRBP vs. PRME - Drawdown Comparison

The maximum CRBP drawdown since its inception was -99.31%, which is greater than PRME's maximum drawdown of -94.55%. Use the drawdown chart below to compare losses from any high point for CRBP and PRME.

Drawdown Indicators

	CRBP	PRME	Difference
Max Drawdown Largest peak-to-trough decline	-99.31%	-94.55%	-4.76%
Max Drawdown (1Y) Largest decline over 1 year	-61.88%	-59.52%	-2.36%
Max Drawdown (3Y) Largest decline over 3 years	-92.01%	-93.26%	+1.25%
Max Drawdown (5Y) Largest decline over 5 years	-96.77%	—	—
Max Drawdown (10Y) Largest decline over 10 years	-99.31%	—	—
Current Drawdown Current decline from peak	-97.62%	-85.13%	-12.49%
Average Drawdown Average peak-to-trough decline	-66.00%	-65.32%	-0.68%
Ulcer Index Depth and duration of drawdowns from previous peaks	39.98%	36.12%	+3.86%

Volatility

CRBP vs. PRME - Volatility Comparison

Corbus Pharmaceuticals Holdings, Inc. (CRBP) has a higher volatility of 44.74% compared to Prime Medicine Inc. Common Stock (PRME) at 21.20%. This indicates that CRBP's price experiences larger fluctuations and is considered to be riskier than PRME based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	CRBP	PRME	Difference
Volatility (1M) Calculated over the trailing 1-month period	44.74%	21.20%	+23.54%
Volatility (6M) Calculated over the trailing 6-month period	60.55%	52.94%	+7.61%
Volatility (1Y) Calculated over the trailing 1-year period	82.11%	99.57%	-17.46%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	159.14%	89.75%	+69.39%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	129.09%	89.75%	+39.34%

Dividends

CRBP vs. PRME - Dividend Comparison

Neither CRBP nor PRME has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both CRBP and PRME in my portfolio?

CRBP and PRME have a correlation of 0.18, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, CRBP or PRME?

CRBP has higher volatility (44.74%) compared to PRME (21.20%). In terms of maximum drawdown, CRBP dropped -99.31% vs PRME's -94.55%.

Which has better risk-adjusted returns?

PRME currently has the higher Sharpe Ratio (1.38 vs -0.14), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.