BBP vs. SBIO

Last updated Aug 2, 2026

BBP (Virtus LifeSci Biotech Products ETF) and SBIO (ALPS Medical Breakthroughs ETF) are both Health & Biotech Equities funds - BBP tracks the LifeSci Biotechnology Products Index while SBIO tracks the S-Network Medical Breakthroughs Index. Both are passively managed. Over the past 10 years, BBP returned 11.65%/yr vs 10.60%/yr for SBIO. Their correlation of 0.89 means they have usually moved in the same direction. BBP charges 0.79%/yr vs 0.50%/yr for SBIO.

Performance

BBP vs. SBIO - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Virtus LifeSci Biotech Products ETF (BBP) and ALPS Medical Breakthroughs ETF (SBIO). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, BBP achieves a 17.46% return, which is significantly lower than SBIO's 23.71% return. Over the past 10 years, BBP has outperformed SBIO with an annualized return of 11.65%, while SBIO has yielded a comparatively lower 10.60% annualized return.

BBP

• 1D: -2.71%
• 1M: -5.26%
• 6M: 15.00%
• YTD: 17.46%
• 1Y: 51.33%
• 3Y*: 19.80%
• 5Y*: 13.17%
• 10Y*: 11.65%
• ALL TIME*: 12.15%

SBIO

• 1D: -2.82%
• 1M: -2.37%
• 6M: 23.63%
• YTD: 23.71%
• 1Y: 93.80%
• 3Y*: 27.24%
• 5Y*: 8.36%
• 10Y*: 10.60%
• ALL TIME*: 9.13%

*Multi-year figures are annualized to reflect compound growth (CAGR)

Liquidity Comparison

Position	Avg. Volume Value (2W)	Avg. Volume Value (1M)	Avg. Volume Value (3M)
BBP Virtus LifeSci Biotech Products ETF	$1.01M	$1.06M	$1.01M
SBIO ALPS Medical Breakthroughs ETF	$1.96M	$3.19M	$2.15M

BBP vs. SBIO - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
BBP Virtus LifeSci Biotech Products ETF	17.46%	33.15%	3.32%	17.88%	0.85%	-8.17%	22.24%	24.73%	-13.95%	24.07%
SBIO ALPS Medical Breakthroughs ETF	23.71%	55.07%	3.81%	8.68%	-28.08%	-17.55%	21.17%	50.30%	-11.81%	45.67%

Correlation

The correlation between BBP and SBIO is 0.87, meaning they have usually moved in the same direction, including during past declines.

	Correlation
Correlation (1Y) Focuses on recent behavior, but can change the most.	0.87
Correlation (3Y) Balances recent behavior with more history.	0.88
Correlation (5Y) Shows whether the relationship held over a longer period.	0.90
Correlation (10Y) Provides a long-term view across more market conditions.	0.89
Correlation (All Time) Calculated using the full available price history since Dec 31, 2014	0.89

The correlation between BBP and SBIO has been stable across timeframes, ranging from 0.87 to 0.90 - a consistent structural relationship.

BBP vs. SBIO - Sectors Allocation Comparison

Sectors	BBP	SBIO
Healthcare	100.0%	100.0%
Basic Materials	-	-
Communication Services	-	-
Consumer Cyclical	-	-
Consumer Defensive	-	-
Energy	-	-
Financial Services	-	-0.0%
Industrials	-	-
Real Estate	-	-
Technology	-	-
Utilities	-	-

Return for Risk

BBP vs. SBIO — Risk / Return Rank

Compare historical risk-adjusted metric ranks over the past 12 months.

BBP

BBP Risk / Return Rank: 90
BBP Sharpe Ratio Rank: 89
BBP Sortino Ratio Rank: 88
BBP Omega Ratio Rank: 83
BBP Calmar Ratio Rank: 95
BBP Martin Ratio Rank: 92

SBIO

SBIO Risk / Return Rank: 95
SBIO Sharpe Ratio Rank: 96
SBIO Sortino Ratio Rank: 94
SBIO Omega Ratio Rank: 92
SBIO Calmar Ratio Rank: 97
SBIO Martin Ratio Rank: 95

The rank (0–100) uses a weighted average of the Sharpe, Sortino, Omega, Calmar, and Martin percentile ranks for the trailing 12 months. Higher means stronger historical risk-adjusted performance within the peer group.

BBP vs. SBIO - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Virtus LifeSci Biotech Products ETF (BBP) and ALPS Medical Breakthroughs ETF (SBIO). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

Values are calculated on a 1-year rolling basis and updated daily. Risk-adjusted metrics are more stable over longer periods — use the period switch above to explore them.

	BBP	SBIO	Difference
Sharpe ratio: Return per unit of total volatility	2.20	3.05	-0.85
Sortino ratio: Return per unit of downside risk	3.02	3.83	-0.81
Omega ratio: Gain probability vs. loss probability	1.36	1.45	-0.10
Calmar ratio: Return relative to maximum drawdown	5.61	7.47	-1.86
Martin ratio: Return relative to average drawdown	15.91	19.68	-3.77

BBP vs. SBIO - Sharpe Ratio Comparison

The current BBP Sharpe Ratio is 2.20, which is comparable to the SBIO Sharpe Ratio of 3.05. The chart below compares the historical Sharpe Ratios of BBP and SBIO, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Drawdowns

BBP vs. SBIO - Drawdown Comparison

The maximum BBP drawdown since its inception was -44.32%, smaller than the maximum SBIO drawdown of -63.06%. Use the drawdown chart below to compare losses from any high point for BBP and SBIO.

Drawdown Indicators

	BBP	SBIO	Difference
Max Drawdown Largest peak-to-trough decline	-44.32%	-63.06%	+18.74%
Max Drawdown (1Y) Largest decline over 1 year	-9.41%	-12.66%	+3.25%
Max Drawdown (3Y) Largest decline over 3 years	-26.09%	-42.44%	+16.35%
Max Drawdown (5Y) Largest decline over 5 years	-37.77%	-52.49%	+14.72%
Max Drawdown (10Y) Largest decline over 10 years	-44.32%	-63.06%	+18.74%
Current Drawdown Current decline from peak	-9.41%	-8.09%	-1.32%
Average Drawdown Average peak-to-trough decline	-11.90%	-28.14%	+16.24%
Ulcer Index Depth and duration of drawdowns from previous peaks	3.31%	4.80%	-1.49%

Volatility

BBP vs. SBIO - Volatility Comparison

The current volatility for Virtus LifeSci Biotech Products ETF (BBP) is 8.02%, while ALPS Medical Breakthroughs ETF (SBIO) has a volatility of 10.05%. This indicates that BBP experiences smaller price fluctuations and is considered to be less risky than SBIO based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	BBP	SBIO	Difference
Volatility (1M) Calculated over the trailing 1-month period	8.02%	10.05%	-2.03%
Volatility (6M) Calculated over the trailing 6-month period	19.16%	24.16%	-5.00%
Volatility (1Y) Calculated over the trailing 1-year period	24.07%	31.04%	-6.97%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	26.42%	33.86%	-7.44%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	27.34%	33.18%	-5.84%

BBP vs. SBIO - Expense Ratio Comparison

BBP has a 0.79% expense ratio, which is higher than SBIO's 0.50% expense ratio.

Dividends

BBP vs. SBIO - Dividend Comparison

Neither BBP nor SBIO has paid dividends to shareholders.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
BBP Virtus LifeSci Biotech Products ETF	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.18%	0.00%	1.29%
SBIO ALPS Medical Breakthroughs ETF	0.00%	0.00%	3.55%	0.22%	0.00%	0.00%	0.00%	0.04%	2.79%	1.77%	0.00%	0.00%

Frequently Asked Questions

Can I hold both BBP and SBIO in my portfolio?

BBP and SBIO have a correlation of 0.87, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, BBP or SBIO?

SBIO has higher volatility (10.05%) compared to BBP (8.02%). In terms of maximum drawdown, BBP dropped -44.32% vs SBIO's -63.06%.

Which ETF is better, BBP or SBIO?

On 10-year performance, BBP leads with 11.65% vs 10.60% for SBIO. On fees, SBIO is cheaper at 0.50% per year. On volatility, BBP has been the lower-risk option at 8.02%. The better choice depends on whether you care most about return, fees, risk, or income.

Which ETF has performed better, BBP or SBIO?

Over the 10-year period, BBP has performed better with a 11.65% return vs 10.60%. Past performance does not guarantee future results, so compare this with risk, fees, and fund exposure.

Which ETF is cheaper, BBP or SBIO?

SBIO is cheaper with a 0.50% expense ratio, compared with 0.79% for BBP.

Which ETF pays a higher dividend yield, BBP or SBIO?

BBP and SBIO have nearly identical dividend yields, around 0.00%.

What is the main difference between BBP and SBIO?

BBP tracks LifeSci Biotechnology Products Index, while SBIO tracks S-Network Medical Breakthroughs Index. They also come from different issuers: Virtus and SS&C. Their fees differ too: 0.79% for BBP and 0.50% for SBIO.

Which has better risk-adjusted returns?

SBIO currently has the higher Sharpe Ratio (3.05 vs 2.19), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.