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APLS vs. VRTX
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Correlation

The correlation between APLS and VRTX is 0.44, which is considered to be moderate. This suggests that the two assets have some degree of positive relationship in their price movements. Moderate correlation can be acceptable for portfolio diversification, offering a balance between risk and potential returns.


Performance

APLS vs. VRTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Apellis Pharmaceuticals, Inc. (APLS) and Vertex Pharmaceuticals Incorporated (VRTX). The values are adjusted to include any dividend payments, if applicable.

50.00%100.00%150.00%200.00%250.00%December2025FebruaryMarchAprilMay
26.94%
189.94%
APLS
VRTX

Key characteristics

Sharpe Ratio

APLS:

-1.08

VRTX:

0.09

Sortino Ratio

APLS:

-1.98

VRTX:

0.47

Omega Ratio

APLS:

0.76

VRTX:

1.07

Calmar Ratio

APLS:

-0.78

VRTX:

0.29

Martin Ratio

APLS:

-1.99

VRTX:

0.77

Ulcer Index

APLS:

31.96%

VRTX:

8.74%

Daily Std Dev

APLS:

53.71%

VRTX:

28.22%

Max Drawdown

APLS:

-81.38%

VRTX:

-91.77%

Current Drawdown

APLS:

-80.91%

VRTX:

-16.86%

Fundamentals

Market Cap

APLS:

$2.56B

VRTX:

$128.84B

EPS

APLS:

-$1.60

VRTX:

-$2.10

PS Ratio

APLS:

3.27

VRTX:

11.67

PB Ratio

APLS:

11.19

VRTX:

7.85

Total Revenue (TTM)

APLS:

$609.04M

VRTX:

$11.09B

Gross Profit (TTM)

APLS:

$511.08M

VRTX:

$9.54B

EBITDA (TTM)

APLS:

-$95.69M

VRTX:

-$228.00M

Returns By Period

In the year-to-date period, APLS achieves a -44.19% return, which is significantly lower than VRTX's 6.68% return.


APLS

YTD

-44.19%

1M

-4.76%

6M

-38.03%

1Y

-57.90%

5Y*

-10.82%

10Y*

N/A

VRTX

YTD

6.68%

1M

-9.05%

6M

-14.50%

1Y

2.57%

5Y*

9.63%

10Y*

13.26%

*Annualized

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Risk-Adjusted Performance

APLS vs. VRTX — Risk-Adjusted Performance Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

APLS
The Risk-Adjusted Performance Rank of APLS is 33
Overall Rank
The Sharpe Ratio Rank of APLS is 33
Sharpe Ratio Rank
The Sortino Ratio Rank of APLS is 33
Sortino Ratio Rank
The Omega Ratio Rank of APLS is 44
Omega Ratio Rank
The Calmar Ratio Rank of APLS is 66
Calmar Ratio Rank
The Martin Ratio Rank of APLS is 11
Martin Ratio Rank

VRTX
The Risk-Adjusted Performance Rank of VRTX is 5757
Overall Rank
The Sharpe Ratio Rank of VRTX is 5656
Sharpe Ratio Rank
The Sortino Ratio Rank of VRTX is 5151
Sortino Ratio Rank
The Omega Ratio Rank of VRTX is 5353
Omega Ratio Rank
The Calmar Ratio Rank of VRTX is 6565
Calmar Ratio Rank
The Martin Ratio Rank of VRTX is 6262
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

APLS vs. VRTX - Risk-Adjusted Performance Comparison

This table presents a comparison of risk-adjusted performance metrics for Apellis Pharmaceuticals, Inc. (APLS) and Vertex Pharmaceuticals Incorporated (VRTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.


The current APLS Sharpe Ratio is -1.08, which is lower than the VRTX Sharpe Ratio of 0.09. The chart below compares the historical Sharpe Ratios of APLS and VRTX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.


Rolling 12-month Sharpe Ratio-1.50-1.00-0.500.000.501.001.502.00December2025FebruaryMarchAprilMay
-1.08
0.09
APLS
VRTX

Dividends

APLS vs. VRTX - Dividend Comparison

Neither APLS nor VRTX has paid dividends to shareholders.


Tickers have no history of dividend payments

Drawdowns

APLS vs. VRTX - Drawdown Comparison

The maximum APLS drawdown since its inception was -81.38%, smaller than the maximum VRTX drawdown of -91.77%. Use the drawdown chart below to compare losses from any high point for APLS and VRTX. For additional features, visit the drawdowns tool.


-80.00%-60.00%-40.00%-20.00%0.00%December2025FebruaryMarchAprilMay
-80.91%
-16.86%
APLS
VRTX

Volatility

APLS vs. VRTX - Volatility Comparison

Apellis Pharmaceuticals, Inc. (APLS) has a higher volatility of 14.79% compared to Vertex Pharmaceuticals Incorporated (VRTX) at 13.26%. This indicates that APLS's price experiences larger fluctuations and is considered to be riskier than VRTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.


5.00%10.00%15.00%20.00%December2025FebruaryMarchAprilMay
14.79%
13.26%
APLS
VRTX

Financials

APLS vs. VRTX - Financials Comparison

This section allows you to compare key financial metrics between Apellis Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.


Quarterly
Annual

Total Revenue: Total amount of money received from sales and other business activities


0.00500.00M1.00B1.50B2.00B2.50B3.00B20212022202320242025
212.53M
2.77B
(APLS) Total Revenue
(VRTX) Total Revenue
Values in USD except per share items

APLS vs. VRTX - Profitability Comparison

The chart below illustrates the profitability comparison between Apellis Pharmaceuticals, Inc. and Vertex Pharmaceuticals Incorporated over time, highlighting three key metrics: Gross Profit Margin, Operating Margin, and Net Profit Margin.

Gross Margin
Operating Margin
Net Margin
Quarterly
Annual

80.0%85.0%90.0%95.0%100.0%20212022202320242025
80.8%
86.9%
(APLS) Gross Margin
(VRTX) Gross Margin
APLS - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported a gross profit of 171.67M and revenue of 212.53M. Therefore, the gross margin over that period was 80.8%.

VRTX - Gross Margin

Gross margin is calculated as gross profit divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported a gross profit of 2.41B and revenue of 2.77B. Therefore, the gross margin over that period was 86.9%.

APLS - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported an operating income of -26.16M and revenue of 212.53M, resulting in an operating margin of -12.3%.

VRTX - Operating Margin

Operating margin is calculated as operating income divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported an operating income of 630.10M and revenue of 2.77B, resulting in an operating margin of 22.8%.

APLS - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Apellis Pharmaceuticals, Inc. reported a net income of -36.35M and revenue of 212.53M, resulting in a net margin of -17.1%.

VRTX - Net Margin

Net margin is calculated as net income divided by revenue. For the three months ending on May 2025, Vertex Pharmaceuticals Incorporated reported a net income of 646.30M and revenue of 2.77B, resulting in a net margin of 23.3%.