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APLI.TO vs. VRTX
Performance
Risk-Adjusted Performance
Dividends
Drawdowns
Volatility
Financials

Correlation

The correlation between APLI.TO and VRTX is 0.40, which is considered to be low. This implies their price changes are not closely related. A low correlation is generally favorable for portfolio diversification, as it helps to reduce overall risk by spreading it across multiple assets with different performance patterns.


Performance

APLI.TO vs. VRTX - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Appili Therapeutics Inc. (APLI.TO) and Vertex Pharmaceuticals Incorporated (VRTX). The values are adjusted to include any dividend payments, if applicable.

-100.00%-50.00%0.00%50.00%100.00%150.00%200.00%December2025FebruaryMarchAprilMay
-95.86%
138.47%
APLI.TO
VRTX

Key characteristics

Sharpe Ratio

APLI.TO:

0.00

VRTX:

0.09

Sortino Ratio

APLI.TO:

1.16

VRTX:

0.47

Omega Ratio

APLI.TO:

1.18

VRTX:

1.07

Calmar Ratio

APLI.TO:

0.00

VRTX:

0.29

Martin Ratio

APLI.TO:

0.00

VRTX:

0.77

Ulcer Index

APLI.TO:

24.44%

VRTX:

8.74%

Daily Std Dev

APLI.TO:

152.25%

VRTX:

28.22%

Max Drawdown

APLI.TO:

-98.66%

VRTX:

-91.77%

Current Drawdown

APLI.TO:

-98.13%

VRTX:

-16.86%

Fundamentals

Market Cap

APLI.TO:

CA$4.24M

VRTX:

$128.84B

EPS

APLI.TO:

-CA$0.03

VRTX:

-$2.10

PS Ratio

APLI.TO:

29.16

VRTX:

11.67

PB Ratio

APLI.TO:

1.40

VRTX:

7.85

Total Revenue (TTM)

APLI.TO:

CA$113.05K

VRTX:

$11.09B

Gross Profit (TTM)

APLI.TO:

-CA$3.37K

VRTX:

$9.54B

EBITDA (TTM)

APLI.TO:

-CA$2.78M

VRTX:

-$228.00M

Returns By Period

In the year-to-date period, APLI.TO achieves a 0.00% return, which is significantly lower than VRTX's 6.68% return.


APLI.TO

YTD

0.00%

1M

40.00%

6M

-12.50%

1Y

0.00%

5Y*

-52.94%

10Y*

N/A

VRTX

YTD

6.68%

1M

-9.05%

6M

-14.50%

1Y

2.57%

5Y*

9.63%

10Y*

13.26%

*Annualized

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Risk-Adjusted Performance

APLI.TO vs. VRTX — Risk-Adjusted Performance Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

APLI.TO
The Risk-Adjusted Performance Rank of APLI.TO is 5959
Overall Rank
The Sharpe Ratio Rank of APLI.TO is 5151
Sharpe Ratio Rank
The Sortino Ratio Rank of APLI.TO is 7070
Sortino Ratio Rank
The Omega Ratio Rank of APLI.TO is 7373
Omega Ratio Rank
The Calmar Ratio Rank of APLI.TO is 5151
Calmar Ratio Rank
The Martin Ratio Rank of APLI.TO is 5151
Martin Ratio Rank

VRTX
The Risk-Adjusted Performance Rank of VRTX is 5757
Overall Rank
The Sharpe Ratio Rank of VRTX is 5656
Sharpe Ratio Rank
The Sortino Ratio Rank of VRTX is 5151
Sortino Ratio Rank
The Omega Ratio Rank of VRTX is 5353
Omega Ratio Rank
The Calmar Ratio Rank of VRTX is 6565
Calmar Ratio Rank
The Martin Ratio Rank of VRTX is 6262
Martin Ratio Rank
The risk-adjusted ranks indicate the investment's position relative to the market. A rank closer to 100 signifies top-performing investments, while a rank closer to 0 might suggest underperformance, based on the selected ratio. The values are calculated based on the past 12 months of returns.

APLI.TO vs. VRTX - Risk-Adjusted Performance Comparison

This table presents a comparison of risk-adjusted performance metrics for Appili Therapeutics Inc. (APLI.TO) and Vertex Pharmaceuticals Incorporated (VRTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.


The current APLI.TO Sharpe Ratio is 0.00, which is lower than the VRTX Sharpe Ratio of 0.09. The chart below compares the historical Sharpe Ratios of APLI.TO and VRTX, offering insights into how both investments have performed under varying market conditions. These values are calculated using daily returns over the previous 12 months.


Rolling 12-month Sharpe Ratio0.000.501.001.50December2025FebruaryMarchAprilMay
-0.01
0.09
APLI.TO
VRTX

Dividends

APLI.TO vs. VRTX - Dividend Comparison

Neither APLI.TO nor VRTX has paid dividends to shareholders.


Tickers have no history of dividend payments

Drawdowns

APLI.TO vs. VRTX - Drawdown Comparison

The maximum APLI.TO drawdown since its inception was -98.66%, which is greater than VRTX's maximum drawdown of -91.77%. Use the drawdown chart below to compare losses from any high point for APLI.TO and VRTX. For additional features, visit the drawdowns tool.


-100.00%-80.00%-60.00%-40.00%-20.00%0.00%December2025FebruaryMarchAprilMay
-98.13%
-16.86%
APLI.TO
VRTX

Volatility

APLI.TO vs. VRTX - Volatility Comparison

Appili Therapeutics Inc. (APLI.TO) has a higher volatility of 49.40% compared to Vertex Pharmaceuticals Incorporated (VRTX) at 13.26%. This indicates that APLI.TO's price experiences larger fluctuations and is considered to be riskier than VRTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.


10.00%20.00%30.00%40.00%50.00%60.00%December2025FebruaryMarchAprilMay
49.40%
13.26%
APLI.TO
VRTX

Financials

APLI.TO vs. VRTX - Financials Comparison

This section allows you to compare key financial metrics between Appili Therapeutics Inc. and Vertex Pharmaceuticals Incorporated. You can select fields from income statements, balance sheets, and cash flow statements to easily visualize and compare the financial health of both companies.


Quarterly
Annual

Total Revenue: Total amount of money received from sales and other business activities


0.00500.00M1.00B1.50B2.00B2.50B3.00B20212022202320242025
108.36K
2.77B
(APLI.TO) Total Revenue
(VRTX) Total Revenue
Please note, different currencies. APLI.TO values in CAD, VRTX values in USD