APLI.TO vs. VRTX

Last updated Jun 5, 2026

APLI.TO (Appili Therapeutics Inc.) and VRTX (Vertex Pharmaceuticals Incorporated) are both stocks. Both operate in the Biotechnology industry within the Healthcare sector. Over the past 5 years, APLI.TO returned -55.40%/yr vs 19.70%/yr for VRTX. At a 0.04 correlation, their price movements are largely independent.

Performance

APLI.TO vs. VRTX - Performance Comparison

The chart below illustrates the hypothetical performance of a CA$10,000 investment in Appili Therapeutics Inc. (APLI.TO) and Vertex Pharmaceuticals Incorporated (VRTX). The values are adjusted to include any dividend payments, if applicable.

Different Trading Currencies

APLI.TO is traded in CAD, while VRTX is traded in USD. To make them comparable, the VRTX values have been converted to CAD using the latest available exchange rates.

Returns By Period

In the year-to-date period, APLI.TO achieves a -40.00% return, which is significantly lower than VRTX's 0.11% return.

APLI.TO

• 1D: -25.00%
• 1M: 0.00%
• YTD: -40.00%
• 6M: -40.00%
• 1Y: 0.00%
• 3Y*: -27.89%
• 5Y*: -55.40%
• 10Y*: —

VRTX

• 1D: 1.36%
• 1M: 6.82%
• YTD: 0.11%
• 6M: -1.02%
• 1Y: 2.62%
• 3Y*: 12.04%
• 5Y*: 19.70%
• 10Y*: 17.83%

*Multi-year figures are annualized to reflect compound growth (CAGR)

APLI.TO vs. VRTX - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019
APLI.TO Appili Therapeutics Inc.	-40.00%	-28.57%	-0.00%	-22.22%	-60.87%	-90.57%	62.67%	-6.25%
VRTX Vertex Pharmaceuticals Incorporated	0.11%	7.42%	7.47%	37.80%	40.87%	-7.92%	6.12%	19.75%

Correlation

The correlation between APLI.TO and VRTX is -0.13, meaning they tend to move in opposite directions. This is especially valuable for risk management - when one declines, the other has historically tended to hold steady or rise.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	-0.13
Correlation (3Y) Calculated over the trailing 3-year period	-0.02
Correlation (5Y) Calculated over the trailing 5-year period	0.00
Correlation (All Time) Calculated using the full available price history since Jun 26, 2019	0.04

The correlation between APLI.TO and VRTX shifts across timeframes, from -0.13 (1 year) to 0.04 (all time), reflecting how their relationship changes across market environments.

Fundamentals

Market Cap APLI.TO : CA$1.93M VRTX : $114.52B
EPS APLI.TO : -CA$0.02 VRTX : $16.87
PS Ratio APLI.TO : 8.99 VRTX : 9.38
Total Revenue (TTM) APLI.TO : CA$206.31K VRTX : $12.26B
Gross Profit (TTM) APLI.TO : CA$84.47K VRTX : $10.57B
EBITDA (TTM) APLI.TO : -CA$1.59M VRTX : $5.19B

Return for Risk

APLI.TO vs. VRTX — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

APLI.TO

APLI.TO Risk / Return Rank: 57
APLI.TO Sharpe Ratio Rank: 41
APLI.TO Sortino Ratio Rank: 78
APLI.TO Omega Ratio Rank: 86
APLI.TO Calmar Ratio Rank: 41
APLI.TO Martin Ratio Rank: 41

VRTX

VRTX Risk / Return Rank: 40
VRTX Sharpe Ratio Rank: 42
VRTX Sortino Ratio Rank: 37
VRTX Omega Ratio Rank: 38
VRTX Calmar Ratio Rank: 42
VRTX Martin Ratio Rank: 42

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

APLI.TO vs. VRTX - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Appili Therapeutics Inc. (APLI.TO) and Vertex Pharmaceuticals Incorporated (VRTX). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	APLI.TO	VRTX	Difference
Sharpe ratio: Return per unit of total volatility	0.00	0.08	-0.08
Sortino ratio: Return per unit of downside risk	2.19	0.33	+1.86
Omega ratio: Gain probability vs. loss probability	1.36	1.05	+0.31
Calmar ratio: Return relative to maximum drawdown	0.00	0.11	-0.11
Martin ratio: Return relative to average drawdown	0.00	0.26	-0.26
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

APLI.TO vs. VRTX - Sharpe Ratio Comparison

The current APLI.TO Sharpe Ratio is 0.00, which is lower than the VRTX Sharpe Ratio of 0.08. The chart below compares the historical Sharpe Ratios of APLI.TO and VRTX, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	APLI.TO	VRTX	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.00	0.08	-0.08
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	-0.32	0.69	-1.01
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	—	0.55	—
Sharpe Ratio (All Time) Calculated using the full available price history	-0.28	0.43	-0.70

Drawdowns

APLI.TO vs. VRTX - Drawdown Comparison

The maximum APLI.TO drawdown since its inception was -99.47%, which is greater than VRTX's maximum drawdown of -50.05%. Use the drawdown chart below to compare losses from any high point for APLI.TO and VRTX.

Drawdown Indicators

	APLI.TO	VRTX	Difference
Max Drawdown Largest peak-to-trough decline	-99.47%	-50.05%	-49.42%
Max Drawdown (1Y) Largest decline over 1 year	-62.50%	-23.09%	-39.41%
Max Drawdown (3Y) Largest decline over 3 years	-85.71%	-31.33%	-54.38%
Max Drawdown (5Y) Largest decline over 5 years	-99.07%	-31.33%	-67.74%
Max Drawdown (10Y) Largest decline over 10 years	—	-45.71%	—
Current Drawdown Current decline from peak	-99.20%	-15.17%	-84.03%
Average Drawdown Average peak-to-trough decline	-77.47%	-15.34%	-62.13%
Ulcer Index Depth and duration of drawdowns from previous peaks	40.24%	10.26%	+29.98%

Volatility

APLI.TO vs. VRTX - Volatility Comparison

Appili Therapeutics Inc. (APLI.TO) has a higher volatility of 65.60% compared to Vertex Pharmaceuticals Incorporated (VRTX) at 7.44%. This indicates that APLI.TO's price experiences larger fluctuations and is considered to be riskier than VRTX based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	APLI.TO	VRTX	Difference
Volatility (1M) Calculated over the trailing 1-month period	65.60%	7.44%	+58.16%
Volatility (6M) Calculated over the trailing 6-month period	158.22%	20.70%	+137.52%
Volatility (1Y) Calculated over the trailing 1-year period	272.14%	33.76%	+238.38%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	175.52%	28.61%	+146.91%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	156.55%	32.42%	+124.13%

Dividends

APLI.TO vs. VRTX - Dividend Comparison

Neither APLI.TO nor VRTX has paid dividends to shareholders.

Tickers have no history of dividend payments

Financials

Frequently Asked Questions

Can I hold both APLI.TO and VRTX in my portfolio?

APLI.TO and VRTX have a correlation of -0.13, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.