AMGN vs. VTI

Last updated Jun 5, 2026

AMGN (Amgen Inc.) is a stock, while VTI (Vanguard Total Stock Market ETF) is Large Cap Blend Equities fund tracking the CRSP US Total Market Index. Over the past 10 years, AMGN returned 11.26%/yr vs 15.04%/yr for VTI. At a 0.49 correlation, their price movements are largely independent.

Performance

AMGN vs. VTI - Performance Comparison

The chart below illustrates the hypothetical performance of a $10,000 investment in Amgen Inc. (AMGN) and Vanguard Total Stock Market ETF (VTI). The values are adjusted to include any dividend payments, if applicable.

Returns By Period

In the year-to-date period, AMGN achieves a 7.12% return, which is significantly lower than VTI's 11.72% return. Over the past 10 years, AMGN has underperformed VTI with an annualized return of 11.26%, while VTI has yielded a comparatively higher 15.04% annualized return.

AMGN

• 1D: 2.18%
• 1M: 5.65%
• YTD: 7.12%
• 6M: 3.08%
• 1Y: 24.03%
• 3Y*: 19.53%
• 5Y*: 11.30%
• 10Y*: 11.26%

VTI

• 1D: 0.47%
• 1M: 4.59%
• YTD: 11.72%
• 6M: 11.43%
• 1Y: 28.79%
• 3Y*: 22.37%
• 5Y*: 12.80%
• 10Y*: 15.04%

*Multi-year figures are annualized to reflect compound growth (CAGR)

AMGN vs. VTI - Yearly Performance Comparison

	2026 (YTD)	2025	2024	2023	2022	2021	2020	2019	2018	2017
AMGN Amgen Inc.	7.12%	29.67%	-6.77%	13.46%	20.43%	0.87%	-1.99%	27.60%	15.23%	22.27%
VTI Vanguard Total Stock Market ETF	11.72%	17.10%	23.81%	26.05%	-19.52%	25.68%	21.08%	30.67%	-5.23%	21.21%

Correlation

The correlation between AMGN and VTI is 0.32, which is low. Their price movements are largely independent, making them effective diversification partners.

	Correlation
Correlation (1Y) Calculated over the trailing 1-year period	0.32
Correlation (3Y) Calculated over the trailing 3-year period	0.35
Correlation (5Y) Calculated over the trailing 5-year period	0.35
Correlation (10Y) Calculated over the trailing 10-year period	0.42
Correlation (All Time) Calculated using the full available price history since Jun 1, 2001	0.49

The correlation between AMGN and VTI shifts across timeframes, from 0.32 (1 year) to 0.49 (all time), reflecting how their relationship changes across market environments.

Return for Risk

AMGN vs. VTI — Risk / Return Rank

Compare risk-adjusted metric ranks to identify better-performing investments over the past 12 months.

AMGN

AMGN Risk / Return Rank: 67
AMGN Sharpe Ratio Rank: 69
AMGN Sortino Ratio Rank: 65
AMGN Omega Ratio Rank: 63
AMGN Calmar Ratio Rank: 69
AMGN Martin Ratio Rank: 69

VTI

VTI Risk / Return Rank: 73
VTI Sharpe Ratio Rank: 74
VTI Sortino Ratio Rank: 73
VTI Omega Ratio Rank: 73
VTI Calmar Ratio Rank: 66
VTI Martin Ratio Rank: 78

The rank (0–100) shows how this investment's returns compare to the risk taken. Higher = better. Based on the past 12 months of data, combining Sharpe, Sortino, and other metrics used by quantitative funds and institutional investors.

AMGN vs. VTI - Risk-Adjusted Trends Comparison

This table presents a comparison of risk-adjusted performance metrics for Amgen Inc. (AMGN) and Vanguard Total Stock Market ETF (VTI). Risk-adjusted metrics are performance indicators that assess an investment's returns in relation to its risk, enabling a more accurate comparison of different investment options.

	AMGN	VTI	Difference
Sharpe ratio: Return per unit of total volatility	0.88	2.38	-1.49
Sortino ratio: Return per unit of downside risk	1.47	3.24	-1.77
Omega ratio: Gain probability vs. loss probability	1.18	1.43	-0.24
Calmar ratio: Return relative to maximum drawdown	1.46	3.24	-1.79
Martin ratio: Return relative to average drawdown	3.43	14.94	-11.52
Data is calculated on a 1-year rolling basis and updated daily. The trend shows the change in the indicator over the past month.

AMGN vs. VTI - Sharpe Ratio Comparison

The current AMGN Sharpe Ratio is 0.88, which is lower than the VTI Sharpe Ratio of 2.38. The chart below compares the historical Sharpe Ratios of AMGN and VTI, calculated using daily returns over the previous 12 months. A higher Sharpe Ratio indicates better risk-adjusted performance relative to the risk-free rate.

Sharpe Ratios by Period

	AMGN	VTI	Difference
Sharpe Ratio (1Y) Calculated over the trailing 1-year period	0.88	2.38	-1.49
Sharpe Ratio (5Y) Calculated over the trailing 5-year period	0.48	0.74	-0.26
Sharpe Ratio (10Y) Calculated over the trailing 10-year period	0.46	0.82	-0.37
Sharpe Ratio (All Time) Calculated using the full available price history	0.61	0.51	+0.10

Drawdowns

AMGN vs. VTI - Drawdown Comparison

The maximum AMGN drawdown since its inception was -63.48%, which is greater than VTI's maximum drawdown of -55.45%. Use the drawdown chart below to compare losses from any high point for AMGN and VTI.

Drawdown Indicators

	AMGN	VTI	Difference
Max Drawdown Largest peak-to-trough decline	-63.48%	-55.45%	-8.03%
Max Drawdown (1Y) Largest decline over 1 year	-16.57%	-8.92%	-7.65%
Max Drawdown (3Y) Largest decline over 3 years	-22.74%	-19.30%	-3.44%
Max Drawdown (5Y) Largest decline over 5 years	-24.86%	-25.36%	+0.50%
Max Drawdown (10Y) Largest decline over 10 years	-24.86%	-35.00%	+10.14%
Current Drawdown Current decline from peak	-10.29%	-0.26%	-10.03%
Average Drawdown Average peak-to-trough decline	-16.78%	-8.03%	-8.75%
Ulcer Index Depth and duration of drawdowns from previous peaks	7.03%	1.93%	+5.10%

Volatility

AMGN vs. VTI - Volatility Comparison

Amgen Inc. (AMGN) has a higher volatility of 6.21% compared to Vanguard Total Stock Market ETF (VTI) at 2.90%. This indicates that AMGN's price experiences larger fluctuations and is considered to be riskier than VTI based on this measure. The chart below showcases a comparison of their rolling one-month volatility.

Volatility by Period

	AMGN	VTI	Difference
Volatility (1M) Calculated over the trailing 1-month period	6.21%	2.90%	+3.31%
Volatility (6M) Calculated over the trailing 6-month period	19.25%	9.13%	+10.12%
Volatility (1Y) Calculated over the trailing 1-year period	27.32%	12.17%	+15.15%
Volatility (5Y) Calculated over the trailing 5-year period, annualized	23.88%	17.40%	+6.48%
Volatility (10Y) Calculated over the trailing 10-year period, annualized	24.81%	18.30%	+6.51%

Dividends

AMGN vs. VTI - Dividend Comparison

AMGN's dividend yield for the trailing twelve months is around 2.84%, more than VTI's 1.01% yield.

Position	TTM	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015
AMGN Amgen Inc.	2.84%	2.91%	3.45%	2.96%	2.95%	3.13%	2.78%	2.41%	2.71%	2.65%	2.74%	1.95%
VTI Vanguard Total Stock Market ETF	1.01%	1.12%	1.27%	1.44%	1.66%	1.21%	1.42%	1.78%	2.04%	1.71%	1.92%	1.98%

Frequently Asked Questions

Can I hold both AMGN and VTI in my portfolio?

AMGN and VTI have a correlation of 0.32, meaning they provide meaningful diversification benefit when combined. Depending on your allocation goals, holding both could reduce overall portfolio risk.

Which is riskier, AMGN or VTI?

AMGN has higher volatility (6.21%) compared to VTI (2.90%). In terms of maximum drawdown, AMGN dropped -63.48% vs VTI's -55.45%.

Which has better risk-adjusted returns?

VTI currently has the higher Sharpe Ratio (2.38 vs 0.88), meaning it's delivered slightly more return per unit of risk over the trailing 12 months. However, this ranking shifts over time - use the Risk/Return Score above for a more comprehensive view that combines Sharpe, Sortino, and other measures used by quantitative funds.